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Abdominal adipose tissue: early metabolic dysfunction associated to insulin resistance and oxidative stress induced by an unbalanced diet.
Horm Metab Res. 2008 Nov; 40(11):794-800.HM

Abstract

The possible contribution of early changes in lipid composition, function, and antioxidant status of abdominal adipose tissue (AAT) induced by a fructose-rich diet (FRD) to the development of insulin resistance (IR) and oxidative stress (OS) was studied. Wistar rats were fed with a commercial diet with (FRD) or without 10% fructose in the drinking water for 3 weeks. The glucose (G), triglyceride (TG), and insulin (I) plasma levels, and the activity of antioxidant enzymes, lyposoluble antioxidants, total glutathione (GSH), lipid peroxidation as TBARS, fatty acid (FA) composition of AAT-TG as well as their release by incubated pieces of AAT were measured. Rats fed with a FRD have significantly higher plasma levels of G, TG, and I. Their AAT showed a marked increase in content and ratios of saturated to monounsaturated and polyunsaturated FAs, TBARS, and catalase, GSH-transferase and GSH-reductase, together with a decrease in superoxide dismutase and GSH-peroxidase activity, and total GSH, alpha-tocopherol, beta-carotene and lycopene content. Incubated AAT from FRD released in vitro higher amount of free fatty acids (FFAs) with higher ratios of saturated to monounsaturated and polyunsaturated FAs. Our data suggest that FRD induced an early prooxidative state and metabolic dysfunction in AAT that would favor the overall development of IR and OS and further development of pancreatic beta-cell failure; therefore, its early control would represent an appropriate strategy to prevent alterations such as the development of type 2 diabetes.

Authors+Show Affiliations

CENEXA-Center of Experimental and Applied Endocrinology (National University of La Plata-National Research Council, PAHO/WHO Collaborating Center), 60 y 120 La Plata, Argentina. oscar_rebolledo@yahoo.com.arNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18622897

Citation

Rebolledo, O R., et al. "Abdominal Adipose Tissue: Early Metabolic Dysfunction Associated to Insulin Resistance and Oxidative Stress Induced By an Unbalanced Diet." Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme, vol. 40, no. 11, 2008, pp. 794-800.
Rebolledo OR, Marra CA, Raschia A, et al. Abdominal adipose tissue: early metabolic dysfunction associated to insulin resistance and oxidative stress induced by an unbalanced diet. Horm Metab Res. 2008;40(11):794-800.
Rebolledo, O. R., Marra, C. A., Raschia, A., Rodriguez, S., & Gagliardino, J. J. (2008). Abdominal adipose tissue: early metabolic dysfunction associated to insulin resistance and oxidative stress induced by an unbalanced diet. Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme, 40(11), 794-800. https://doi.org/10.1055/s-2008-1081502
Rebolledo OR, et al. Abdominal Adipose Tissue: Early Metabolic Dysfunction Associated to Insulin Resistance and Oxidative Stress Induced By an Unbalanced Diet. Horm Metab Res. 2008;40(11):794-800. PubMed PMID: 18622897.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Abdominal adipose tissue: early metabolic dysfunction associated to insulin resistance and oxidative stress induced by an unbalanced diet. AU - Rebolledo,O R, AU - Marra,C A, AU - Raschia,A, AU - Rodriguez,S, AU - Gagliardino,J J, Y1 - 2008/07/11/ PY - 2008/7/16/pubmed PY - 2009/2/14/medline PY - 2008/7/16/entrez SP - 794 EP - 800 JF - Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme JO - Horm Metab Res VL - 40 IS - 11 N2 - The possible contribution of early changes in lipid composition, function, and antioxidant status of abdominal adipose tissue (AAT) induced by a fructose-rich diet (FRD) to the development of insulin resistance (IR) and oxidative stress (OS) was studied. Wistar rats were fed with a commercial diet with (FRD) or without 10% fructose in the drinking water for 3 weeks. The glucose (G), triglyceride (TG), and insulin (I) plasma levels, and the activity of antioxidant enzymes, lyposoluble antioxidants, total glutathione (GSH), lipid peroxidation as TBARS, fatty acid (FA) composition of AAT-TG as well as their release by incubated pieces of AAT were measured. Rats fed with a FRD have significantly higher plasma levels of G, TG, and I. Their AAT showed a marked increase in content and ratios of saturated to monounsaturated and polyunsaturated FAs, TBARS, and catalase, GSH-transferase and GSH-reductase, together with a decrease in superoxide dismutase and GSH-peroxidase activity, and total GSH, alpha-tocopherol, beta-carotene and lycopene content. Incubated AAT from FRD released in vitro higher amount of free fatty acids (FFAs) with higher ratios of saturated to monounsaturated and polyunsaturated FAs. Our data suggest that FRD induced an early prooxidative state and metabolic dysfunction in AAT that would favor the overall development of IR and OS and further development of pancreatic beta-cell failure; therefore, its early control would represent an appropriate strategy to prevent alterations such as the development of type 2 diabetes. SN - 0018-5043 UR - https://www.unboundmedicine.com/medline/citation/18622897/Abdominal_adipose_tissue:_early_metabolic_dysfunction_associated_to_insulin_resistance_and_oxidative_stress_induced_by_an_unbalanced_diet_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2008-1081502 DB - PRIME DP - Unbound Medicine ER -