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In vitro and in vivo treatments of echinococcus protoscoleces and metacestodes with artemisinin and artemisinin derivatives.
Antimicrob Agents Chemother. 2008 Sep; 52(9):3447-50.AA

Abstract

In vitro treatment of Echinococcus multilocularis and Echinococcus granulosus larval stages with the antimalarials dihydroartemisinin and artesunate (10 to 40 microM) exhibited promising results, while 6 weeks of in vivo treatment of mice infected with E. multilocularis metacestodes (200 mg/kg of body weight/day) had no effect. However, combination treatments of both drugs with albendazole led to a substantial but statistically not significant reduction in parasite weight compared to results with albendazole alone.

Authors+Show Affiliations

Institute of Parasitology, University of Bern, Länggass-Strasse 122, CH-3012 Bern, Switzerland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18625777

Citation

Spicher, Martin, et al. "In Vitro and in Vivo Treatments of Echinococcus Protoscoleces and Metacestodes With Artemisinin and Artemisinin Derivatives." Antimicrobial Agents and Chemotherapy, vol. 52, no. 9, 2008, pp. 3447-50.
Spicher M, Roethlisberger C, Lany C, et al. In vitro and in vivo treatments of echinococcus protoscoleces and metacestodes with artemisinin and artemisinin derivatives. Antimicrob Agents Chemother. 2008;52(9):3447-50.
Spicher, M., Roethlisberger, C., Lany, C., Stadelmann, B., Keiser, J., Ortega-Mora, L. M., Gottstein, B., & Hemphill, A. (2008). In vitro and in vivo treatments of echinococcus protoscoleces and metacestodes with artemisinin and artemisinin derivatives. Antimicrobial Agents and Chemotherapy, 52(9), 3447-50. https://doi.org/10.1128/AAC.00553-08
Spicher M, et al. In Vitro and in Vivo Treatments of Echinococcus Protoscoleces and Metacestodes With Artemisinin and Artemisinin Derivatives. Antimicrob Agents Chemother. 2008;52(9):3447-50. PubMed PMID: 18625777.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In vitro and in vivo treatments of echinococcus protoscoleces and metacestodes with artemisinin and artemisinin derivatives. AU - Spicher,Martin, AU - Roethlisberger,Carole, AU - Lany,Catharina, AU - Stadelmann,Britta, AU - Keiser,Jennifer, AU - Ortega-Mora,Luis M, AU - Gottstein,Bruno, AU - Hemphill,Andrew, Y1 - 2008/07/14/ PY - 2008/7/16/pubmed PY - 2008/10/24/medline PY - 2008/7/16/entrez SP - 3447 EP - 50 JF - Antimicrobial agents and chemotherapy JO - Antimicrob. Agents Chemother. VL - 52 IS - 9 N2 - In vitro treatment of Echinococcus multilocularis and Echinococcus granulosus larval stages with the antimalarials dihydroartemisinin and artesunate (10 to 40 microM) exhibited promising results, while 6 weeks of in vivo treatment of mice infected with E. multilocularis metacestodes (200 mg/kg of body weight/day) had no effect. However, combination treatments of both drugs with albendazole led to a substantial but statistically not significant reduction in parasite weight compared to results with albendazole alone. SN - 1098-6596 UR - https://www.unboundmedicine.com/medline/citation/18625777/In_vitro_and_in_vivo_treatments_of_echinococcus_protoscoleces_and_metacestodes_with_artemisinin_and_artemisinin_derivatives_ L2 - http://aac.asm.org/cgi/pmidlookup?view=long&pmid=18625777 DB - PRIME DP - Unbound Medicine ER -