Tags

Type your tag names separated by a space and hit enter

Plasma lipoproteins and apolipoproteins in insulin-dependent and young non-insulin-dependent Arab women.
Acta Diabetol Lat 1991 Jan-Mar; 28(1):61-9AD

Abstract

Plasma lipids, lipoproteins and apolipoproteins (apo) were analysed in 30 young Arab IDDM and 50 young insulin-requiring NIDDM women. The mean age of IDDM and NIDDM groups was 20.2 and 34.5 years, and mean duration of diabetes was 5.7 and 4.6 years, respectively. Two groups of 40 and 60 healthy women (matched for age and BMI) provided corresponding control groups. In comparison with control subjects, diabetics showed marked increases in the following parameters: total cholesterol (TC), low density lipoprotein (LDL) cholesterol, total triglycerides (TG), very low density lipoprotein (VLDL) triglycerides, phospholipids, apoB, LDL apoB, glucose and glycosylated hemoglobin (HbA1c) as well as the ratios of total cholesterol/high density lipoprotein (HDL) cholesterol, LDL-cholesterol/HDL-cholesterol, LDL cholesterol/high density lipoprotein (HDL) cholesterol, LDL-cholesterol/HDL-cholesterol, LDL cholesterol/high density lipoprotein 2 (HDL2) cholesterol and apoB/apoAI. Plasma LCAT activity, concentrations of HDL3 apoAI and apoAII in plasma and lipoprotein fractions were normal in both the diabetic groups. Levels of C-peptide, HDL, HDL2 and HDL3 cholesterol, plasma apoAI, HDL apoAI and HDL2 apoAI were markedly decreased in the diabetic groups as compared to their corresponding controls. There was no significant correlation between fasting glucose or HbA1c and any of the above parameters. Despite insulin therapy in both the diabetic groups studied, abnormalities in lipids, apoB and apoAI still persisted. Our data suggest a possible higher risk of atherosclerosis in these patients.

Authors+Show Affiliations

Department of Medicine, Faculty of Medicine, Kuwait University.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1862693

Citation

al-Muhtaseb, N, et al. "Plasma Lipoproteins and Apolipoproteins in Insulin-dependent and Young Non-insulin-dependent Arab Women." Acta Diabetologica Latina, vol. 28, no. 1, 1991, pp. 61-9.
al-Muhtaseb N, al-Yuosuf AR, Bajaj JS. Plasma lipoproteins and apolipoproteins in insulin-dependent and young non-insulin-dependent Arab women. Acta Diabetol Lat. 1991;28(1):61-9.
al-Muhtaseb, N., al-Yuosuf, A. R., & Bajaj, J. S. (1991). Plasma lipoproteins and apolipoproteins in insulin-dependent and young non-insulin-dependent Arab women. Acta Diabetologica Latina, 28(1), pp. 61-9.
al-Muhtaseb N, al-Yuosuf AR, Bajaj JS. Plasma Lipoproteins and Apolipoproteins in Insulin-dependent and Young Non-insulin-dependent Arab Women. Acta Diabetol Lat. 1991;28(1):61-9. PubMed PMID: 1862693.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma lipoproteins and apolipoproteins in insulin-dependent and young non-insulin-dependent Arab women. AU - al-Muhtaseb,N, AU - al-Yuosuf,A R, AU - Bajaj,J S, PY - 1991/1/1/pubmed PY - 1991/1/1/medline PY - 1991/1/1/entrez SP - 61 EP - 9 JF - Acta diabetologica latina JO - Acta Diabetol Lat VL - 28 IS - 1 N2 - Plasma lipids, lipoproteins and apolipoproteins (apo) were analysed in 30 young Arab IDDM and 50 young insulin-requiring NIDDM women. The mean age of IDDM and NIDDM groups was 20.2 and 34.5 years, and mean duration of diabetes was 5.7 and 4.6 years, respectively. Two groups of 40 and 60 healthy women (matched for age and BMI) provided corresponding control groups. In comparison with control subjects, diabetics showed marked increases in the following parameters: total cholesterol (TC), low density lipoprotein (LDL) cholesterol, total triglycerides (TG), very low density lipoprotein (VLDL) triglycerides, phospholipids, apoB, LDL apoB, glucose and glycosylated hemoglobin (HbA1c) as well as the ratios of total cholesterol/high density lipoprotein (HDL) cholesterol, LDL-cholesterol/HDL-cholesterol, LDL cholesterol/high density lipoprotein (HDL) cholesterol, LDL-cholesterol/HDL-cholesterol, LDL cholesterol/high density lipoprotein 2 (HDL2) cholesterol and apoB/apoAI. Plasma LCAT activity, concentrations of HDL3 apoAI and apoAII in plasma and lipoprotein fractions were normal in both the diabetic groups. Levels of C-peptide, HDL, HDL2 and HDL3 cholesterol, plasma apoAI, HDL apoAI and HDL2 apoAI were markedly decreased in the diabetic groups as compared to their corresponding controls. There was no significant correlation between fasting glucose or HbA1c and any of the above parameters. Despite insulin therapy in both the diabetic groups studied, abnormalities in lipids, apoB and apoAI still persisted. Our data suggest a possible higher risk of atherosclerosis in these patients. SN - 0001-5563 UR - https://www.unboundmedicine.com/medline/citation/1862693/Plasma_lipoproteins_and_apolipoproteins_in_insulin_dependent_and_young_non_insulin_dependent_Arab_women_ L2 - https://medlineplus.gov/diabetestype2.html DB - PRIME DP - Unbound Medicine ER -