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Seroprevalence of viral hepatitis and infectious complications among human immunodeficiency virus-infected injection drug users at a referral hospital.
J Microbiol Immunol Infect. 2008 Jun; 41(3):200-8.JM

Abstract

BACKGROUND AND PURPOSE

The seroprevalence of viral hepatitis and spectrum of infectious complications among human immunodeficiency virus (HIV)-infected injection drug users (IDUs) remains unclear in Taiwan, although there has been a significant increase in the prevalence of HIV infection among IDUs in the last 2 to 3 years.

METHODS

The medical records of HIV-infected IDUs who sought medical care at a referral hospital for HIV care from June 1994 to December 2006 were retrospectively reviewed. A standardized case record form was used to collect demographic, clinical, laboratory and microbiologic data.

RESULTS

During the 12-year study period, a total of 102 HIV-infected IDUs with a median age of 39.5 years (range, 19 to 73 years) sought HIV care at the referral hospital. The male-to-female case ratio was 6 and males were significantly older than females (39.5 vs 28 years, p<0.001). The overall median CD4+ cell count and plasma HIV RNA load by reverse transcriptase-polymerase chain reaction at enrollment were 374 cells/microL and 4.45 log(10) copies/mL, respectively. The CD4+ cell count of HIV-infected IDUs enrolled after year 2003 was significantly higher than those enrolled before 2003 (438 vs 23 cells/microL, p<0.001). The seroprevalence of hepatitis C virus (86.6% overall) increased over time, while that of hepatitis B virus decreased in the patients born after 1984, when nationwide hepatitis B vaccination was started in Taiwan. Gram-positive bacteria were causative for 69.7% of the 33 bacteremic episodes, and Staphylococcus aureus was the leading pathogen (16 episodes), with methicillin-sensitive S. aureus accounting for 11 bacteremic episodes (33.3%). The most common bacterial infection was infective endocarditis. Tuberculosis occurred more frequently in men, and extrapulmonary tuberculosis was more common than pulmonary tuberculosis and was associated with a lower CD4+ count.

CONCLUSIONS

Bacteremia, infective endocarditis and tuberculosis were the three most common patterns of infection among HIV-infected IDUs who sought medical care at a referral hospital; and methicillin-sensitive S. aureus was the most common etiology of bacteremia. The high seroprevalence of hepatitis B and C and subsequent hepatic complications may present a future challenge to the health care system.

Authors+Show Affiliations

Section of Infectious Disease, Department of Internal Medicine, E-Da Hospital, I-Shou University, Kaohsiung County, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18629414

Citation

Liang, Shiou Haur, et al. "Seroprevalence of Viral Hepatitis and Infectious Complications Among Human Immunodeficiency Virus-infected Injection Drug Users at a Referral Hospital." Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi, vol. 41, no. 3, 2008, pp. 200-8.
Liang SH, Lo YC, Lin HH, et al. Seroprevalence of viral hepatitis and infectious complications among human immunodeficiency virus-infected injection drug users at a referral hospital. J Microbiol Immunol Infect. 2008;41(3):200-8.
Liang, S. H., Lo, Y. C., Lin, H. H., Chang, S. Y., Chen, M. Y., Hsieh, S. M., Sheng, W. H., Sun, H. Y., Hung, C. C., & Chang, S. C. (2008). Seroprevalence of viral hepatitis and infectious complications among human immunodeficiency virus-infected injection drug users at a referral hospital. Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi, 41(3), 200-8.
Liang SH, et al. Seroprevalence of Viral Hepatitis and Infectious Complications Among Human Immunodeficiency Virus-infected Injection Drug Users at a Referral Hospital. J Microbiol Immunol Infect. 2008;41(3):200-8. PubMed PMID: 18629414.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Seroprevalence of viral hepatitis and infectious complications among human immunodeficiency virus-infected injection drug users at a referral hospital. AU - Liang,Shiou Haur, AU - Lo,Yi-Chun, AU - Lin,Hsi-Hsun, AU - Chang,Sui-Yuan, AU - Chen,Mao-Yuan, AU - Hsieh,Szu-Min, AU - Sheng,Wang-Huei, AU - Sun,Hsin-Yun, AU - Hung,Chien-Ching, AU - Chang,Shan-Chwen, PY - 2008/7/17/pubmed PY - 2008/10/16/medline PY - 2008/7/17/entrez SP - 200 EP - 8 JF - Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi JO - J Microbiol Immunol Infect VL - 41 IS - 3 N2 - BACKGROUND AND PURPOSE: The seroprevalence of viral hepatitis and spectrum of infectious complications among human immunodeficiency virus (HIV)-infected injection drug users (IDUs) remains unclear in Taiwan, although there has been a significant increase in the prevalence of HIV infection among IDUs in the last 2 to 3 years. METHODS: The medical records of HIV-infected IDUs who sought medical care at a referral hospital for HIV care from June 1994 to December 2006 were retrospectively reviewed. A standardized case record form was used to collect demographic, clinical, laboratory and microbiologic data. RESULTS: During the 12-year study period, a total of 102 HIV-infected IDUs with a median age of 39.5 years (range, 19 to 73 years) sought HIV care at the referral hospital. The male-to-female case ratio was 6 and males were significantly older than females (39.5 vs 28 years, p<0.001). The overall median CD4+ cell count and plasma HIV RNA load by reverse transcriptase-polymerase chain reaction at enrollment were 374 cells/microL and 4.45 log(10) copies/mL, respectively. The CD4+ cell count of HIV-infected IDUs enrolled after year 2003 was significantly higher than those enrolled before 2003 (438 vs 23 cells/microL, p<0.001). The seroprevalence of hepatitis C virus (86.6% overall) increased over time, while that of hepatitis B virus decreased in the patients born after 1984, when nationwide hepatitis B vaccination was started in Taiwan. Gram-positive bacteria were causative for 69.7% of the 33 bacteremic episodes, and Staphylococcus aureus was the leading pathogen (16 episodes), with methicillin-sensitive S. aureus accounting for 11 bacteremic episodes (33.3%). The most common bacterial infection was infective endocarditis. Tuberculosis occurred more frequently in men, and extrapulmonary tuberculosis was more common than pulmonary tuberculosis and was associated with a lower CD4+ count. CONCLUSIONS: Bacteremia, infective endocarditis and tuberculosis were the three most common patterns of infection among HIV-infected IDUs who sought medical care at a referral hospital; and methicillin-sensitive S. aureus was the most common etiology of bacteremia. The high seroprevalence of hepatitis B and C and subsequent hepatic complications may present a future challenge to the health care system. SN - 1684-1182 UR - https://www.unboundmedicine.com/medline/citation/18629414/Seroprevalence_of_viral_hepatitis_and_infectious_complications_among_human_immunodeficiency_virus_infected_injection_drug_users_at_a_referral_hospital_ L2 - http://www.diseaseinfosearch.org/result/3332 DB - PRIME DP - Unbound Medicine ER -