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[Effects of electroacupuncture on plasma and cerebral somatostatin and beta-EP contents and learning-memory ability in vascular dementia rats].
Zhen Ci Yan Jiu. 2008 Apr; 33(2):98-102.ZC

Abstract

OBJECTIVE

To observe the effect of electroacupuncture (EA) on learning-memory ability of vascular dementia (VD) rats, and the simultaneous changes of plasma and cerebral somatostatin (SS) and beta-endorphin (EP) contents.

METHODS

Forty-one SD rats were randomly divided into control (n=8), model A (n=8, no treatment) and B (n=8, intragastric perfusion of 15% saline), EA (n=9) and medication (n=8, intragastric perfusion of Nimoldipine, 12 mg/kg) groups. VD model was established by using modified 4-vessels occlusion method. EA (150 Hz, 1-2 mA) was applied to "Baihui" (GV 20), "Dazhui" (DU 14), "Pishu" (BL 20) and "Shenshu" (BL 23) for 20 min, once daily for 15 days. Morris water maze tests were conducted for evaluating the rats' learning-memory ability. The contents of SS and beta-EP in plasma and brain tissue were measured by radioimmunoassay (RIA).

RESULTS

In comparison with sham-operation group, the escape latency (EL) prolonged significantly and the target-platform crossing times decreased remarkably (P<0.01) in model group B. In comparison with model group B, EL shortened and target-platform crossing times increased both significantly in EA and medication groups (P<0.01). Plasma and cerebral SS, and cerebral beta-EP contents of model groups A and B were significantly lower than those of sham-operation group(P<0.01), while plasma beta-EP level had no obvious change (P>0.05). Plasma and cerebral SS, and cerebral beta-EP contents in both EA and medication groups were considerably higher than those in model groups A and B (P<0.01). No significant differences were found between EA and medication groups in EL, target-platform crossing times, plasma and cerebral SS and beta-EP levels, and between model group A and model group B in plasma and cerebral SS and beta-EP levels (P>0.05).

CONCLUSION

EA can raise plasma and cerebral SS and cerebral beta-EP levels, and improve the learning-memory ability in VD rats.

Authors+Show Affiliations

Acu-moxibustion and Massage, Guangzhou University of Chinese Medicine, Guangzhou 510405, China. jenna.s.y@163.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

18630584

Citation

Shao, Ying, et al. "[Effects of Electroacupuncture On Plasma and Cerebral Somatostatin and beta-EP Contents and Learning-memory Ability in Vascular Dementia Rats]." Zhen Ci Yan Jiu = Acupuncture Research, vol. 33, no. 2, 2008, pp. 98-102.
Shao Y, Lai XS, Gong YZ, et al. [Effects of electroacupuncture on plasma and cerebral somatostatin and beta-EP contents and learning-memory ability in vascular dementia rats]. Zhen Ci Yan Jiu. 2008;33(2):98-102.
Shao, Y., Lai, X. S., Gong, Y. Z., Yan, B., He, L. L., Luo, R., & Tang, C. Z. (2008). [Effects of electroacupuncture on plasma and cerebral somatostatin and beta-EP contents and learning-memory ability in vascular dementia rats]. Zhen Ci Yan Jiu = Acupuncture Research, 33(2), 98-102.
Shao Y, et al. [Effects of Electroacupuncture On Plasma and Cerebral Somatostatin and beta-EP Contents and Learning-memory Ability in Vascular Dementia Rats]. Zhen Ci Yan Jiu. 2008;33(2):98-102. PubMed PMID: 18630584.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effects of electroacupuncture on plasma and cerebral somatostatin and beta-EP contents and learning-memory ability in vascular dementia rats]. AU - Shao,Ying, AU - Lai,Xin-Sheng, AU - Gong,Yu-Zhuo, AU - Yan,Bing, AU - He,Li-Lei, AU - Luo,Ren, AU - Tang,Chun-Zhi, PY - 2008/7/18/pubmed PY - 2008/7/30/medline PY - 2008/7/18/entrez SP - 98 EP - 102 JF - Zhen ci yan jiu = Acupuncture research JO - Zhen Ci Yan Jiu VL - 33 IS - 2 N2 - OBJECTIVE: To observe the effect of electroacupuncture (EA) on learning-memory ability of vascular dementia (VD) rats, and the simultaneous changes of plasma and cerebral somatostatin (SS) and beta-endorphin (EP) contents. METHODS: Forty-one SD rats were randomly divided into control (n=8), model A (n=8, no treatment) and B (n=8, intragastric perfusion of 15% saline), EA (n=9) and medication (n=8, intragastric perfusion of Nimoldipine, 12 mg/kg) groups. VD model was established by using modified 4-vessels occlusion method. EA (150 Hz, 1-2 mA) was applied to "Baihui" (GV 20), "Dazhui" (DU 14), "Pishu" (BL 20) and "Shenshu" (BL 23) for 20 min, once daily for 15 days. Morris water maze tests were conducted for evaluating the rats' learning-memory ability. The contents of SS and beta-EP in plasma and brain tissue were measured by radioimmunoassay (RIA). RESULTS: In comparison with sham-operation group, the escape latency (EL) prolonged significantly and the target-platform crossing times decreased remarkably (P<0.01) in model group B. In comparison with model group B, EL shortened and target-platform crossing times increased both significantly in EA and medication groups (P<0.01). Plasma and cerebral SS, and cerebral beta-EP contents of model groups A and B were significantly lower than those of sham-operation group(P<0.01), while plasma beta-EP level had no obvious change (P>0.05). Plasma and cerebral SS, and cerebral beta-EP contents in both EA and medication groups were considerably higher than those in model groups A and B (P<0.01). No significant differences were found between EA and medication groups in EL, target-platform crossing times, plasma and cerebral SS and beta-EP levels, and between model group A and model group B in plasma and cerebral SS and beta-EP levels (P>0.05). CONCLUSION: EA can raise plasma and cerebral SS and cerebral beta-EP levels, and improve the learning-memory ability in VD rats. SN - 1000-0607 UR - https://www.unboundmedicine.com/medline/citation/18630584/[Effects_of_electroacupuncture_on_plasma_and_cerebral_somatostatin_and_beta_EP_contents_and_learning_memory_ability_in_vascular_dementia_rats]_ L2 - https://medlineplus.gov/memory.html DB - PRIME DP - Unbound Medicine ER -