Tags

Type your tag names separated by a space and hit enter

Supplementation with Lactobacillus rhamnosus or Bifidobacterium lactis probiotics in pregnancy increases cord blood interferon-gamma and breast milk transforming growth factor-beta and immunoglobin A detection.
Clin Exp Allergy. 2008 Oct; 38(10):1606-14.CE

Abstract

BACKGROUND

This study explored the effects of maternal probiotic supplementation on immune markers in cord blood (CB) and breast milk.

METHODS

CB plasma and breast milk samples were collected from a cohort of women who had received daily supplements of either 6 x 10(9) CFU/day Lactobacillus rhamnosus HN001 (n=34), 9 x 10(9) CFU/day Bifidobacterium lactis HN019 (n=35) or a placebo (n=36) beginning 2-5 weeks before delivery and continuing for 6 months in lactating women. CB plasma and breast milk (collected at 3-7 days, 3 months and 6 months postpartum) were assayed for cytokines (IL-13, IFN-gamma, IL-6, TNF-alpha, IL-10, TGF-beta1) and sCD14. Breast milk samples were also assayed for total IgA.

RESULTS

Neonates of mothers who received a probiotic had higher CB IFN-gamma levels (P=0.026), and a higher proportion had detectable blood IFN-gamma levels, compared with the placebo group (P=0.034), although levels were undetectable in many infants. While this pattern was evident for both probiotics, when examined separately only the L. rhamnosus HN001 group showed statistically significant higher IFN-gamma levels (P=0.030) compared with the placebo group. TGF-beta1 levels were higher in early breast milk (week 1) from the probiotic groups (P=0.028). This was evident for the B. lactis HN019 group (P=0.041) with a parallel trend in the L. rhamnosus HN001 group (P=0.075). Similar patterns were seen for breast milk IgA, which was more readily detected in breast milk from both the B. lactis HN019 (P=0.008) and the L. rhamnosus HN001 group (P=0.011). Neonatal plasma sCD14 levels were lower in the B. lactis HN019 group compared with the placebo group (P=0.041).

CONCLUSION

The findings suggest that supplementation with probiotics in pregnancy has the potential to influence fetal immune parameters as well as immunomodulatory factors in breast milk.

Authors+Show Affiliations

School of Paediatrics and Child Health, University of Western Australia, Perth, Australia. sprescott@meddent.uwa.edu.auNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18631345

Citation

Prescott, S L., et al. "Supplementation With Lactobacillus Rhamnosus or Bifidobacterium Lactis Probiotics in Pregnancy Increases Cord Blood Interferon-gamma and Breast Milk Transforming Growth Factor-beta and Immunoglobin a Detection." Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, vol. 38, no. 10, 2008, pp. 1606-14.
Prescott SL, Wickens K, Westcott L, et al. Supplementation with Lactobacillus rhamnosus or Bifidobacterium lactis probiotics in pregnancy increases cord blood interferon-gamma and breast milk transforming growth factor-beta and immunoglobin A detection. Clin Exp Allergy. 2008;38(10):1606-14.
Prescott, S. L., Wickens, K., Westcott, L., Jung, W., Currie, H., Black, P. N., Stanley, T. V., Mitchell, E. A., Fitzharris, P., Siebers, R., Wu, L., & Crane, J. (2008). Supplementation with Lactobacillus rhamnosus or Bifidobacterium lactis probiotics in pregnancy increases cord blood interferon-gamma and breast milk transforming growth factor-beta and immunoglobin A detection. Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, 38(10), 1606-14. https://doi.org/10.1111/j.1365-2222.2008.03061.x
Prescott SL, et al. Supplementation With Lactobacillus Rhamnosus or Bifidobacterium Lactis Probiotics in Pregnancy Increases Cord Blood Interferon-gamma and Breast Milk Transforming Growth Factor-beta and Immunoglobin a Detection. Clin Exp Allergy. 2008;38(10):1606-14. PubMed PMID: 18631345.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Supplementation with Lactobacillus rhamnosus or Bifidobacterium lactis probiotics in pregnancy increases cord blood interferon-gamma and breast milk transforming growth factor-beta and immunoglobin A detection. AU - Prescott,S L, AU - Wickens,K, AU - Westcott,L, AU - Jung,W, AU - Currie,H, AU - Black,P N, AU - Stanley,T V, AU - Mitchell,E A, AU - Fitzharris,P, AU - Siebers,R, AU - Wu,L, AU - Crane,J, AU - ,, Y1 - 2008/07/02/ PY - 2008/7/18/pubmed PY - 2009/1/23/medline PY - 2008/7/18/entrez SP - 1606 EP - 14 JF - Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology JO - Clin. Exp. Allergy VL - 38 IS - 10 N2 - BACKGROUND: This study explored the effects of maternal probiotic supplementation on immune markers in cord blood (CB) and breast milk. METHODS: CB plasma and breast milk samples were collected from a cohort of women who had received daily supplements of either 6 x 10(9) CFU/day Lactobacillus rhamnosus HN001 (n=34), 9 x 10(9) CFU/day Bifidobacterium lactis HN019 (n=35) or a placebo (n=36) beginning 2-5 weeks before delivery and continuing for 6 months in lactating women. CB plasma and breast milk (collected at 3-7 days, 3 months and 6 months postpartum) were assayed for cytokines (IL-13, IFN-gamma, IL-6, TNF-alpha, IL-10, TGF-beta1) and sCD14. Breast milk samples were also assayed for total IgA. RESULTS: Neonates of mothers who received a probiotic had higher CB IFN-gamma levels (P=0.026), and a higher proportion had detectable blood IFN-gamma levels, compared with the placebo group (P=0.034), although levels were undetectable in many infants. While this pattern was evident for both probiotics, when examined separately only the L. rhamnosus HN001 group showed statistically significant higher IFN-gamma levels (P=0.030) compared with the placebo group. TGF-beta1 levels were higher in early breast milk (week 1) from the probiotic groups (P=0.028). This was evident for the B. lactis HN019 group (P=0.041) with a parallel trend in the L. rhamnosus HN001 group (P=0.075). Similar patterns were seen for breast milk IgA, which was more readily detected in breast milk from both the B. lactis HN019 (P=0.008) and the L. rhamnosus HN001 group (P=0.011). Neonatal plasma sCD14 levels were lower in the B. lactis HN019 group compared with the placebo group (P=0.041). CONCLUSION: The findings suggest that supplementation with probiotics in pregnancy has the potential to influence fetal immune parameters as well as immunomodulatory factors in breast milk. SN - 1365-2222 UR - https://www.unboundmedicine.com/medline/citation/18631345/Supplementation_with_Lactobacillus_rhamnosus_or_Bifidobacterium_lactis_probiotics_in_pregnancy_increases_cord_blood_interferon_gamma_and_breast_milk_transforming_growth_factor_beta_and_immunoglobin_A_detection_ L2 - https://doi.org/10.1111/j.1365-2222.2008.03061.x DB - PRIME DP - Unbound Medicine ER -