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Diffuse uterine leiomyomatosis with hemorrhage.
Arch Pathol Lab Med. 1991 Aug; 115(8):834-7.AP

Abstract

A 28-year-old woman with primary infertility and severe menorrhagia underwent a hysterectomy after failed hormonal therapy for multiple leiomyomas. The postoperative pathologic findings established the diagnosis of diffuse uterine leiomyomatosis, which demonstrated histologic, immunohistochemical, and ultrastructural similarity to leiomyomas of the uterus. The rapid growth of the tumor coincided with the administration of clomiphene citrate, an estrogenic agonist. As with the common leiomyoma, intralesional hemorrhage in this case of diffuse leiomyomatosis was associated with norethindrone acetate treatment given after the cessation of clomiphene therapy.

Authors+Show Affiliations

Lai FM
Department of Anatomical and Cellular Pathology, Chinese University of Hong Kong.
Wong FW
No affiliation info available
Allen PW
No affiliation info available

MeSH

AdultClomipheneFemaleHumansImmunohistochemistryInfertility, FemaleLeiomyomaMenorrhagiaNorethindroneNorethindrone AcetateUterine Neoplasms

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

1863197

Citation

Lai, F M., et al. "Diffuse Uterine Leiomyomatosis With Hemorrhage." Archives of Pathology & Laboratory Medicine, vol. 115, no. 8, 1991, pp. 834-7.
Lai FM, Wong FW, Allen PW. Diffuse uterine leiomyomatosis with hemorrhage. Arch Pathol Lab Med. 1991;115(8):834-7.
Lai, F. M., Wong, F. W., & Allen, P. W. (1991). Diffuse uterine leiomyomatosis with hemorrhage. Archives of Pathology & Laboratory Medicine, 115(8), 834-7.
Lai FM, Wong FW, Allen PW. Diffuse Uterine Leiomyomatosis With Hemorrhage. Arch Pathol Lab Med. 1991;115(8):834-7. PubMed PMID: 1863197.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diffuse uterine leiomyomatosis with hemorrhage. AU - Lai,F M, AU - Wong,F W, AU - Allen,P W, PY - 1991/8/1/pubmed PY - 1991/8/1/medline PY - 1991/8/1/entrez SP - 834 EP - 7 JF - Archives of pathology & laboratory medicine JO - Arch Pathol Lab Med VL - 115 IS - 8 N2 - A 28-year-old woman with primary infertility and severe menorrhagia underwent a hysterectomy after failed hormonal therapy for multiple leiomyomas. The postoperative pathologic findings established the diagnosis of diffuse uterine leiomyomatosis, which demonstrated histologic, immunohistochemical, and ultrastructural similarity to leiomyomas of the uterus. The rapid growth of the tumor coincided with the administration of clomiphene citrate, an estrogenic agonist. As with the common leiomyoma, intralesional hemorrhage in this case of diffuse leiomyomatosis was associated with norethindrone acetate treatment given after the cessation of clomiphene therapy. SN - 0003-9985 UR - https://www.unboundmedicine.com/medline/citation/1863197/Diffuse_uterine_leiomyomatosis_with_hemorrhage_ DB - PRIME DP - Unbound Medicine ER -