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The pivotal role of vasopressin in refractory anaphylactic shock.
Anesth Analg 2008; 107(2):620-4A&A

Abstract

BACKGROUND

Severe anaphylaxis can be associated with cardiovascular collapse that is difficult to manage and does not respond to treatment with epinephrine. Because anaphylaxis is uncommon, unpredictable and may be fatal, a prospective, randomized, controlled trial in humans on the best management is difficult and guidelines are based on theory and anecdotes only.

METHODS AND RESULTS

We report six cases in which the use of vasopressin was successful in the treatment of anaphylactic shock.

CONCLUSIONS

Standard treatment of anaphylactic shock, including discontinuation of the causative agent, administration of epinephrine, and infusion of IV fluids, did not stabilize cardiocirculatory function, and adding arginine vasopressors resulted in prompt hemodynamic stabilization.

Authors+Show Affiliations

Department for Anesthesiology and Intensive Care Medicine, SRH Zentralklinikum Suhl, Albert-Schweitzer str. 2, 98527 Suhl, Germany. cwsm.schummer@gmx.deNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

18633042

Citation

Schummer, Claudia, et al. "The Pivotal Role of Vasopressin in Refractory Anaphylactic Shock." Anesthesia and Analgesia, vol. 107, no. 2, 2008, pp. 620-4.
Schummer C, Wirsing M, Schummer W. The pivotal role of vasopressin in refractory anaphylactic shock. Anesth Analg. 2008;107(2):620-4.
Schummer, C., Wirsing, M., & Schummer, W. (2008). The pivotal role of vasopressin in refractory anaphylactic shock. Anesthesia and Analgesia, 107(2), pp. 620-4. doi:10.1213/ane.0b013e3181770b42.
Schummer C, Wirsing M, Schummer W. The Pivotal Role of Vasopressin in Refractory Anaphylactic Shock. Anesth Analg. 2008;107(2):620-4. PubMed PMID: 18633042.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The pivotal role of vasopressin in refractory anaphylactic shock. AU - Schummer,Claudia, AU - Wirsing,Melanie, AU - Schummer,Wolfram, PY - 2008/7/18/pubmed PY - 2008/8/30/medline PY - 2008/7/18/entrez SP - 620 EP - 4 JF - Anesthesia and analgesia JO - Anesth. Analg. VL - 107 IS - 2 N2 - BACKGROUND: Severe anaphylaxis can be associated with cardiovascular collapse that is difficult to manage and does not respond to treatment with epinephrine. Because anaphylaxis is uncommon, unpredictable and may be fatal, a prospective, randomized, controlled trial in humans on the best management is difficult and guidelines are based on theory and anecdotes only. METHODS AND RESULTS: We report six cases in which the use of vasopressin was successful in the treatment of anaphylactic shock. CONCLUSIONS: Standard treatment of anaphylactic shock, including discontinuation of the causative agent, administration of epinephrine, and infusion of IV fluids, did not stabilize cardiocirculatory function, and adding arginine vasopressors resulted in prompt hemodynamic stabilization. SN - 1526-7598 UR - https://www.unboundmedicine.com/medline/citation/18633042/The_pivotal_role_of_vasopressin_in_refractory_anaphylactic_shock_ L2 - http://Insights.ovid.com/pubmed?pmid=18633042 DB - PRIME DP - Unbound Medicine ER -