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Epidemiology and pathogenicity of African bat lyssaviruses.
Dev Biol (Basel). 2008; 131:317-25.DB

Abstract

Lyssaviruses belonging to all four known African Lyssavirus genotypes (gts) have been reported and isolated from SouthAfrica over the past few decades. These are: (1) Duvenhage virus (gt4), isolated again in 2006 from a human fatality; (2) Mokola virus (gt3), isolated irregularly, mostly from cats; (3) Lagos bat virus (gt2) continually isolated over the past four years from Epomophorus fruit bats and from incidental terrestrial animals and (4) Rabies virus (gt1) - with two virus biotypes endemic in mongoose and in canid species (mostly domestic dogs, jackals and bat-eared foxes), respectively. Only two of these are associated with bats in Southern Africa, viz. Duvenhage virus and Lagos bat virus (gts 4 and 2). For both these genotypes the authors have embarked on a programme of comparative study of molecular epidemiology. Duvenhage virus nucleoprotein nucleotide sequence analysis indicated a very low nucleotide diversity even though isolates were isolated decades apart. In contrast, individual isolates of Lagos bat virus were found to differ significantly with respectto nucleoprotein gene nucleotide sequence diversity as well as in pathogenicity profiles.

Authors+Show Affiliations

Department of Microbiology and Plant Pathology, Faculty of Natural and Agricultural Sciences, University of Pretoria, South Africa.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18634494

Citation

Markotter, W, et al. "Epidemiology and Pathogenicity of African Bat Lyssaviruses." Developments in Biologicals, vol. 131, 2008, pp. 317-25.
Markotter W, Van Eeden C, Kuzmin IV, et al. Epidemiology and pathogenicity of African bat lyssaviruses. Dev Biol (Basel). 2008;131:317-25.
Markotter, W., Van Eeden, C., Kuzmin, I. V., Rupprecht, C. E., Paweska, J. T., Swanepoel, R., Fooks, A. R., Sabeta, C. T., Cliquet, F., & Nel, L. H. (2008). Epidemiology and pathogenicity of African bat lyssaviruses. Developments in Biologicals, 131, 317-25.
Markotter W, et al. Epidemiology and Pathogenicity of African Bat Lyssaviruses. Dev Biol (Basel). 2008;131:317-25. PubMed PMID: 18634494.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Epidemiology and pathogenicity of African bat lyssaviruses. AU - Markotter,W, AU - Van Eeden,C, AU - Kuzmin,I V, AU - Rupprecht,C E, AU - Paweska,J T, AU - Swanepoel,R, AU - Fooks,A R, AU - Sabeta,C T, AU - Cliquet,F, AU - Nel,L H, PY - 2008/7/19/pubmed PY - 2008/10/2/medline PY - 2008/7/19/entrez SP - 317 EP - 25 JF - Developments in biologicals JO - Dev Biol (Basel) VL - 131 N2 - Lyssaviruses belonging to all four known African Lyssavirus genotypes (gts) have been reported and isolated from SouthAfrica over the past few decades. These are: (1) Duvenhage virus (gt4), isolated again in 2006 from a human fatality; (2) Mokola virus (gt3), isolated irregularly, mostly from cats; (3) Lagos bat virus (gt2) continually isolated over the past four years from Epomophorus fruit bats and from incidental terrestrial animals and (4) Rabies virus (gt1) - with two virus biotypes endemic in mongoose and in canid species (mostly domestic dogs, jackals and bat-eared foxes), respectively. Only two of these are associated with bats in Southern Africa, viz. Duvenhage virus and Lagos bat virus (gts 4 and 2). For both these genotypes the authors have embarked on a programme of comparative study of molecular epidemiology. Duvenhage virus nucleoprotein nucleotide sequence analysis indicated a very low nucleotide diversity even though isolates were isolated decades apart. In contrast, individual isolates of Lagos bat virus were found to differ significantly with respectto nucleoprotein gene nucleotide sequence diversity as well as in pathogenicity profiles. SN - 1424-6074 UR - https://www.unboundmedicine.com/medline/citation/18634494/Epidemiology_and_pathogenicity_of_African_bat_lyssaviruses_ DB - PRIME DP - Unbound Medicine ER -