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One or three intradermal injections within one week for rabies pre-exposure immunization.
Dev Biol (Basel). 2008; 131:393-401.DB

Abstract

Pre-exposure rabies vaccination is recommended fortravellers to endemic countries and forselected populations in highly endemic regions. It consists of three injections administered over 3-4 weeks. Travellers often ignore or do not have enough time to receive a complete course prior to departure or leave with only one or two injections. In this study, the secondary antibody response in volunteers who received one or three injections within one week is evaluated. Results are compared to the recommended three injection regimen when administered with two booster vaccinations on days 0 and 3 one year later. Long-lasting immune memory in volunteers who received only one time vaccination of 0.1 ml (1 site) intradermally and then received two booster vaccinations of 0.1 ml (1 site) intradermally on days 0 and 3, one or three years later is also reported. All volunteers developed an accelerated and adequate neutralizing antibody response within seven days after they received two boosters. These data suggest that three injections within one week are as immunogenic as three injections within four weeks. One clinic visit with two-site 0.1 ml ID injections or a one-site single 0.1 ml pre-exposure rabies vaccination is enough to prime the host immune memory for at least one to three years.

Authors+Show Affiliations

Queen Saovabha Memorial Institute, The Thai Red Cross Society, Bangkok, Thailand. pakamatz@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18634501

Citation

Khawplod, P, et al. "One or Three Intradermal Injections Within One Week for Rabies Pre-exposure Immunization." Developments in Biologicals, vol. 131, 2008, pp. 393-401.
Khawplod P, Wilde H, Sriaroon C, et al. One or three intradermal injections within one week for rabies pre-exposure immunization. Dev Biol (Basel). 2008;131:393-401.
Khawplod, P., Wilde, H., Sriaroon, C., Chomchey, P., Kamolthum, T., & Sitprija, V. (2008). One or three intradermal injections within one week for rabies pre-exposure immunization. Developments in Biologicals, 131, 393-401.
Khawplod P, et al. One or Three Intradermal Injections Within One Week for Rabies Pre-exposure Immunization. Dev Biol (Basel). 2008;131:393-401. PubMed PMID: 18634501.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - One or three intradermal injections within one week for rabies pre-exposure immunization. AU - Khawplod,P, AU - Wilde,H, AU - Sriaroon,C, AU - Chomchey,P, AU - Kamolthum,T, AU - Sitprija,V, PY - 2008/7/19/pubmed PY - 2008/10/2/medline PY - 2008/7/19/entrez SP - 393 EP - 401 JF - Developments in biologicals JO - Dev Biol (Basel) VL - 131 N2 - Pre-exposure rabies vaccination is recommended fortravellers to endemic countries and forselected populations in highly endemic regions. It consists of three injections administered over 3-4 weeks. Travellers often ignore or do not have enough time to receive a complete course prior to departure or leave with only one or two injections. In this study, the secondary antibody response in volunteers who received one or three injections within one week is evaluated. Results are compared to the recommended three injection regimen when administered with two booster vaccinations on days 0 and 3 one year later. Long-lasting immune memory in volunteers who received only one time vaccination of 0.1 ml (1 site) intradermally and then received two booster vaccinations of 0.1 ml (1 site) intradermally on days 0 and 3, one or three years later is also reported. All volunteers developed an accelerated and adequate neutralizing antibody response within seven days after they received two boosters. These data suggest that three injections within one week are as immunogenic as three injections within four weeks. One clinic visit with two-site 0.1 ml ID injections or a one-site single 0.1 ml pre-exposure rabies vaccination is enough to prime the host immune memory for at least one to three years. SN - 1424-6074 UR - https://www.unboundmedicine.com/medline/citation/18634501/One_or_three_intradermal_injections_within_one_week_for_rabies_pre_exposure_immunization_ L2 - http://www.diseaseinfosearch.org/result/6131 DB - PRIME DP - Unbound Medicine ER -