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[Antimicrobial activity of ornidazole and 6 other antibiotics against anaerobic bacteria].
Enferm Infecc Microbiol Clin. 1991 Apr; 9(4):219-22.EI

Abstract

The antimicrobial susceptibility of 235 anaerobic bacterial strains to ornidazole, metronidazole, chloramphenicol, clindamycin, penicillin, cefoxitin and imipenem has been studied using agar-dilution technique. Ornidazole and metronidazole were active against 88.6% and 86% of gram-positive cocci. Overall, 99.1% of Bacteroides group fragilis, and 91.3% of non-fragilis Bacteroides were also sensitive to both drugs. We did not find any Clostridium perfringens resistant strain. Cefoxitin and penicillin showed good activity against all Clostridium perfringens strains, and also against 97.7% and 92.5% of gram-positive cocci. We found one single imipenem resistant strain among gram-positive bacteria. Bacteroides fragilis also showed sensitivity to penicillin (41.5%), cefoxitin (85.7%) and imipenem (97.1%). Clindamycin was active against Clostridium perfringens (90.9%), gram-positive cocci (86.7%) and imipenem (68.6%). Chloramphenicol showed good activity against Clostridium perfringens (100%), gram-positive cocci (95.5%) and Bacteroides spp. (99.4%). Our results showed an overall good activity of all the seven drugs tested against anaerobic gram-positive microorganisms. Of notice, we found a good activity of chloramphenicol, imipenem, metronidazole and ornidazole against Bacteroides spp.

Authors+Show Affiliations

Alados JC
Servicio de Bacteriología, Hospital Virgen de las Nieves, Granada.
Martínez-Brocal A
No affiliation info available
Miranda C
No affiliation info available
Rojo MD
No affiliation info available
García V
No affiliation info available
Domínguez MC
No affiliation info available
de la Rosa M
No affiliation info available

MeSH

Anti-Bacterial AgentsBacteria, AnaerobicBacterial InfectionsDrug Resistance, MicrobialMicrobial Sensitivity TestsOrnidazoleSpecies Specificity

Pub Type(s)

Comparative Study
English Abstract
Journal Article

Language

spa

PubMed ID

1863621

Citation

Alados, J C., et al. "[Antimicrobial Activity of Ornidazole and 6 Other Antibiotics Against Anaerobic Bacteria]." Enfermedades Infecciosas Y Microbiologia Clinica, vol. 9, no. 4, 1991, pp. 219-22.
Alados JC, Martínez-Brocal A, Miranda C, et al. [Antimicrobial activity of ornidazole and 6 other antibiotics against anaerobic bacteria]. Enferm Infecc Microbiol Clin. 1991;9(4):219-22.
Alados, J. C., Martínez-Brocal, A., Miranda, C., Rojo, M. D., García, V., Domínguez, M. C., & de la Rosa, M. (1991). [Antimicrobial activity of ornidazole and 6 other antibiotics against anaerobic bacteria]. Enfermedades Infecciosas Y Microbiologia Clinica, 9(4), 219-22.
Alados JC, et al. [Antimicrobial Activity of Ornidazole and 6 Other Antibiotics Against Anaerobic Bacteria]. Enferm Infecc Microbiol Clin. 1991;9(4):219-22. PubMed PMID: 1863621.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Antimicrobial activity of ornidazole and 6 other antibiotics against anaerobic bacteria]. AU - Alados,J C, AU - Martínez-Brocal,A, AU - Miranda,C, AU - Rojo,M D, AU - García,V, AU - Domínguez,M C, AU - de la Rosa,M, PY - 1991/4/1/pubmed PY - 1991/4/1/medline PY - 1991/4/1/entrez SP - 219 EP - 22 JF - Enfermedades infecciosas y microbiologia clinica JO - Enferm Infecc Microbiol Clin VL - 9 IS - 4 N2 - The antimicrobial susceptibility of 235 anaerobic bacterial strains to ornidazole, metronidazole, chloramphenicol, clindamycin, penicillin, cefoxitin and imipenem has been studied using agar-dilution technique. Ornidazole and metronidazole were active against 88.6% and 86% of gram-positive cocci. Overall, 99.1% of Bacteroides group fragilis, and 91.3% of non-fragilis Bacteroides were also sensitive to both drugs. We did not find any Clostridium perfringens resistant strain. Cefoxitin and penicillin showed good activity against all Clostridium perfringens strains, and also against 97.7% and 92.5% of gram-positive cocci. We found one single imipenem resistant strain among gram-positive bacteria. Bacteroides fragilis also showed sensitivity to penicillin (41.5%), cefoxitin (85.7%) and imipenem (97.1%). Clindamycin was active against Clostridium perfringens (90.9%), gram-positive cocci (86.7%) and imipenem (68.6%). Chloramphenicol showed good activity against Clostridium perfringens (100%), gram-positive cocci (95.5%) and Bacteroides spp. (99.4%). Our results showed an overall good activity of all the seven drugs tested against anaerobic gram-positive microorganisms. Of notice, we found a good activity of chloramphenicol, imipenem, metronidazole and ornidazole against Bacteroides spp. SN - 0213-005X UR - https://www.unboundmedicine.com/medline/citation/1863621/[Antimicrobial_activity_of_ornidazole_and_6_other_antibiotics_against_anaerobic_bacteria]_ DB - PRIME DP - Unbound Medicine ER -