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Comparative efficacy assessment of tamsulosin vs. tamsulosin plus tadalafil in the treatment of LUTS/BPH. Pilot study.
J Sex Med. 2008 Sep; 5(9):2170-8.JS

Abstract

INTRODUCTION

The high incidence of erectile dysfunction (ED) and lower urinary tract symptoms (LUTS) in aging men and the same pathophysiology make probable to treat both disorders with the same treatment. Numerous authors evaluated the actions of PDE5i in improving the LUTS/(benign prostate hyperplasia) BPH.

AIM

To assess the efficacy and safety of tamsulosin 0.4 mg/day vs. tamsulosin 0.4 mg/day plus tadalafil 20 mg/day in patients with LUTS in a crossover design study.

MAIN OUTCOMES MEASURES

International Prostate Symptoms Score (IPSS), IPSS Quality of Life (IPSS-QOL), maximum flow rate (Qmax), post-void residual volume (PVR), International Index of Erectile Function-Erectile Function Domain (IIEF-EF), Global Assessment Quality (GAQ). For the statistical analysis, a Tukey-Kramer multicomparison test was used.

METHODS

A randomized, double-blind, crossover study was conducted from September 2007 to February 2008 in one center. Thirty men, older than 50 years old, with a history of LUTS/BPH of at least 6 months, were randomized into two groups to receive tamsulosin 0.4 mg/day vs. tamsulosin 0.4 mg/day plus tadalafil 20 mg/day for 45 days, and then switched to the other treatment mode for other 45 days.

RESULTS

Twenty-seven patients completed the study. Improvements of IPSS score and IPSS-QOL were significant with both treatments but greater with the drug combination. Both regimens similarly improved the Qmax and decreased the PVR volume from baseline (P < 0.001) with no significant differences between tamsulosin alone vs. tamsulosin and tadalafil (P > 0.05). The IIEF improved with tamsulosin plus tadalafil (P < 0.001) but not with tamsulosin alone (P > 0.05). The GAQ showed that all patients preferred the combination scheme. Both treatments were well tolerated. CONCLUSION; Tamsulosin 0.4 mg/day plus tadalafil 20 mg/day was more effective than tamsulosin 0.4 mg/day alone to improve LUTS and erectile dysfunction and was also well tolerated. Large-scale, randomized, placebo-controlled studies are needed to further assess the long-term safety and effectiveness of these agents in treating LUTS/BPH with or without ED.

Authors+Show Affiliations

División Urología, Hospital Durand, Buenos Aires, Argentina. amadobechara@fibertel.com.arNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

18638006

Citation

Bechara, Amado, et al. "Comparative Efficacy Assessment of Tamsulosin Vs. Tamsulosin Plus Tadalafil in the Treatment of LUTS/BPH. Pilot Study." The Journal of Sexual Medicine, vol. 5, no. 9, 2008, pp. 2170-8.
Bechara A, Romano S, Casabé A, et al. Comparative efficacy assessment of tamsulosin vs. tamsulosin plus tadalafil in the treatment of LUTS/BPH. Pilot study. J Sex Med. 2008;5(9):2170-8.
Bechara, A., Romano, S., Casabé, A., Haime, S., Dedola, P., Hernández, C., & Rey, H. (2008). Comparative efficacy assessment of tamsulosin vs. tamsulosin plus tadalafil in the treatment of LUTS/BPH. Pilot study. The Journal of Sexual Medicine, 5(9), 2170-8. https://doi.org/10.1111/j.1743-6109.2008.00940.x
Bechara A, et al. Comparative Efficacy Assessment of Tamsulosin Vs. Tamsulosin Plus Tadalafil in the Treatment of LUTS/BPH. Pilot Study. J Sex Med. 2008;5(9):2170-8. PubMed PMID: 18638006.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparative efficacy assessment of tamsulosin vs. tamsulosin plus tadalafil in the treatment of LUTS/BPH. Pilot study. AU - Bechara,Amado, AU - Romano,Salomon, AU - Casabé,Adolfo, AU - Haime,Sergio, AU - Dedola,Pablo, AU - Hernández,Cecilia, AU - Rey,Horacio, Y1 - 2008/07/14/ PY - 2008/7/22/pubmed PY - 2009/1/24/medline PY - 2008/7/22/entrez SP - 2170 EP - 8 JF - The journal of sexual medicine JO - J Sex Med VL - 5 IS - 9 N2 - INTRODUCTION: The high incidence of erectile dysfunction (ED) and lower urinary tract symptoms (LUTS) in aging men and the same pathophysiology make probable to treat both disorders with the same treatment. Numerous authors evaluated the actions of PDE5i in improving the LUTS/(benign prostate hyperplasia) BPH. AIM: To assess the efficacy and safety of tamsulosin 0.4 mg/day vs. tamsulosin 0.4 mg/day plus tadalafil 20 mg/day in patients with LUTS in a crossover design study. MAIN OUTCOMES MEASURES: International Prostate Symptoms Score (IPSS), IPSS Quality of Life (IPSS-QOL), maximum flow rate (Qmax), post-void residual volume (PVR), International Index of Erectile Function-Erectile Function Domain (IIEF-EF), Global Assessment Quality (GAQ). For the statistical analysis, a Tukey-Kramer multicomparison test was used. METHODS: A randomized, double-blind, crossover study was conducted from September 2007 to February 2008 in one center. Thirty men, older than 50 years old, with a history of LUTS/BPH of at least 6 months, were randomized into two groups to receive tamsulosin 0.4 mg/day vs. tamsulosin 0.4 mg/day plus tadalafil 20 mg/day for 45 days, and then switched to the other treatment mode for other 45 days. RESULTS: Twenty-seven patients completed the study. Improvements of IPSS score and IPSS-QOL were significant with both treatments but greater with the drug combination. Both regimens similarly improved the Qmax and decreased the PVR volume from baseline (P < 0.001) with no significant differences between tamsulosin alone vs. tamsulosin and tadalafil (P > 0.05). The IIEF improved with tamsulosin plus tadalafil (P < 0.001) but not with tamsulosin alone (P > 0.05). The GAQ showed that all patients preferred the combination scheme. Both treatments were well tolerated. CONCLUSION; Tamsulosin 0.4 mg/day plus tadalafil 20 mg/day was more effective than tamsulosin 0.4 mg/day alone to improve LUTS and erectile dysfunction and was also well tolerated. Large-scale, randomized, placebo-controlled studies are needed to further assess the long-term safety and effectiveness of these agents in treating LUTS/BPH with or without ED. SN - 1743-6109 UR - https://www.unboundmedicine.com/medline/citation/18638006/Comparative_efficacy_assessment_of_tamsulosin_vs__tamsulosin_plus_tadalafil_in_the_treatment_of_LUTS/BPH__Pilot_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1743-6095(15)32153-6 DB - PRIME DP - Unbound Medicine ER -