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A pyrazole derivative of curcumin enhances memory.
Neurobiol Aging. 2010 Apr; 31(4):706-9.NA

Abstract

Reduced cognitive function is associated with Alzheimer's and Parkinson's diseases as well as brain trauma and ischemia. However, there are few compounds that enhance memory and are also orally active. We recently synthesized a pyrazole derivative of curcumin called CNB-001 that enhances the activity of Ca(2+)/calmodulin dependent protein kinase II (CaMKII). Since CaMKII plays a central role in long-term potentiation (LTP) and memory, it was asked if CNB-001 can facilitate the induction of LTP in rat hippocampal slices and enhance memory in a rat object recognition test. It is shown that CNB-001 enhances both LTP and memory.

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Authors+Show Affiliations

Maher P
The Salk Institute, Laboratories for Cellular Neurobiology, 10010 North Torrey Pines Road, La Jolla, CA 92037-1099, USA. pmaher@salk.edu
Akaishi T
No affiliation info available
Schubert D
No affiliation info available
Abe K
No affiliation info available

MeSH

AnimalsCalcium-Calmodulin-Dependent Protein Kinase Type 2Cognition DisordersCurcuminHippocampusLong-Term PotentiationMaleMemoryMemory DisordersNerve DegenerationNeurodegenerative DiseasesNeuroprotective AgentsNeuropsychological TestsNootropic AgentsOrgan Culture TechniquesPyrazolesRatsRats, WistarRecognition, PsychologyTreatment Outcome

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18639368

Citation

Maher, Pamela, et al. "A Pyrazole Derivative of Curcumin Enhances Memory." Neurobiology of Aging, vol. 31, no. 4, 2010, pp. 706-9.
Maher P, Akaishi T, Schubert D, et al. A pyrazole derivative of curcumin enhances memory. Neurobiol Aging. 2010;31(4):706-9.
Maher, P., Akaishi, T., Schubert, D., & Abe, K. (2010). A pyrazole derivative of curcumin enhances memory. Neurobiology of Aging, 31(4), 706-9. https://doi.org/10.1016/j.neurobiolaging.2008.05.020
Maher P, et al. A Pyrazole Derivative of Curcumin Enhances Memory. Neurobiol Aging. 2010;31(4):706-9. PubMed PMID: 18639368.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A pyrazole derivative of curcumin enhances memory. AU - Maher,Pamela, AU - Akaishi,Tatsuhiro, AU - Schubert,David, AU - Abe,Kazuho, Y1 - 2008/07/17/ PY - 2008/03/11/received PY - 2008/05/14/revised PY - 2008/05/20/accepted PY - 2008/7/22/pubmed PY - 2010/6/9/medline PY - 2008/7/22/entrez SP - 706 EP - 9 JF - Neurobiology of aging JO - Neurobiol Aging VL - 31 IS - 4 N2 - Reduced cognitive function is associated with Alzheimer's and Parkinson's diseases as well as brain trauma and ischemia. However, there are few compounds that enhance memory and are also orally active. We recently synthesized a pyrazole derivative of curcumin called CNB-001 that enhances the activity of Ca(2+)/calmodulin dependent protein kinase II (CaMKII). Since CaMKII plays a central role in long-term potentiation (LTP) and memory, it was asked if CNB-001 can facilitate the induction of LTP in rat hippocampal slices and enhance memory in a rat object recognition test. It is shown that CNB-001 enhances both LTP and memory. SN - 1558-1497 UR - https://www.unboundmedicine.com/medline/citation/18639368/A_pyrazole_derivative_of_curcumin_enhances_memory_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0197-4580(08)00173-5 DB - PRIME DP - Unbound Medicine ER -