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Long-term fish consumption and n-3 fatty acid intake in relation to (sudden) coronary heart disease death: the Zutphen study.
Eur Heart J. 2008 Aug; 29(16):2024-30.EH

Abstract

AIMS

To assess the relationship between fish consumption or eicosapentaenoic acid (EPA)+docosahexaenoic acid (DHA) intake from fish, and (sudden) coronary death.

METHODS AND RESULTS

The impact of recent and long-term fish consumption and EPA+DHA intake on (sudden) coronary death was investigated in the Zutphen Study, a cohort of 1373 men born between 1900 and 1920, and examined repeatedly between 1960 and 2000. Hazard ratios were obtained from time-dependent Cox regression models. The associations between long-term fish consumption, EPA+DHA intake, and (sudden) coronary death were stronger than those of recent consumption. Long-term fish consumption was inversely associated (borderline significant) with coronary heart disease (CHD) death; however, the strength of the association decreased from age 50 [HR: 0.32 (95% CI: 0.13-0.80)] until age 80 [HR: 1.34 (0.58-3.12)]. For men with a daily EPA+DHA intake from fish below 250 mg compared with no intake, CHD death risk was reduced to the same extent as for men with a daily intake above 250 mg (P-value for trend: 0.27). Moreover, long-term fatty-fish consumption lowered the risk of sudden coronary death [HR: 0.46 (0.27-0.78)].

CONCLUSION

The strength of the association between long-term fish consumption and CHD death decreased with increasing age. Fatty-fish consumption lowered sudden coronary death risk. There was no clear dose-response relationship between EPA+DHA intake and (sudden) coronary death.

Authors+Show Affiliations

National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands. martinette.streppel@wur.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18641046

Citation

Streppel, Martinette T., et al. "Long-term Fish Consumption and N-3 Fatty Acid Intake in Relation to (sudden) Coronary Heart Disease Death: the Zutphen Study." European Heart Journal, vol. 29, no. 16, 2008, pp. 2024-30.
Streppel MT, Ocké MC, Boshuizen HC, et al. Long-term fish consumption and n-3 fatty acid intake in relation to (sudden) coronary heart disease death: the Zutphen study. Eur Heart J. 2008;29(16):2024-30.
Streppel, M. T., Ocké, M. C., Boshuizen, H. C., Kok, F. J., & Kromhout, D. (2008). Long-term fish consumption and n-3 fatty acid intake in relation to (sudden) coronary heart disease death: the Zutphen study. European Heart Journal, 29(16), 2024-30. https://doi.org/10.1093/eurheartj/ehn294
Streppel MT, et al. Long-term Fish Consumption and N-3 Fatty Acid Intake in Relation to (sudden) Coronary Heart Disease Death: the Zutphen Study. Eur Heart J. 2008;29(16):2024-30. PubMed PMID: 18641046.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Long-term fish consumption and n-3 fatty acid intake in relation to (sudden) coronary heart disease death: the Zutphen study. AU - Streppel,Martinette T, AU - Ocké,Marga C, AU - Boshuizen,Hendriek C, AU - Kok,Frans J, AU - Kromhout,Daan, Y1 - 2008/07/18/ PY - 2008/7/22/pubmed PY - 2009/2/6/medline PY - 2008/7/22/entrez SP - 2024 EP - 30 JF - European heart journal JO - Eur Heart J VL - 29 IS - 16 N2 - AIMS: To assess the relationship between fish consumption or eicosapentaenoic acid (EPA)+docosahexaenoic acid (DHA) intake from fish, and (sudden) coronary death. METHODS AND RESULTS: The impact of recent and long-term fish consumption and EPA+DHA intake on (sudden) coronary death was investigated in the Zutphen Study, a cohort of 1373 men born between 1900 and 1920, and examined repeatedly between 1960 and 2000. Hazard ratios were obtained from time-dependent Cox regression models. The associations between long-term fish consumption, EPA+DHA intake, and (sudden) coronary death were stronger than those of recent consumption. Long-term fish consumption was inversely associated (borderline significant) with coronary heart disease (CHD) death; however, the strength of the association decreased from age 50 [HR: 0.32 (95% CI: 0.13-0.80)] until age 80 [HR: 1.34 (0.58-3.12)]. For men with a daily EPA+DHA intake from fish below 250 mg compared with no intake, CHD death risk was reduced to the same extent as for men with a daily intake above 250 mg (P-value for trend: 0.27). Moreover, long-term fatty-fish consumption lowered the risk of sudden coronary death [HR: 0.46 (0.27-0.78)]. CONCLUSION: The strength of the association between long-term fish consumption and CHD death decreased with increasing age. Fatty-fish consumption lowered sudden coronary death risk. There was no clear dose-response relationship between EPA+DHA intake and (sudden) coronary death. SN - 1522-9645 UR - https://www.unboundmedicine.com/medline/citation/18641046/Long_term_fish_consumption_and_n_3_fatty_acid_intake_in_relation_to__sudden__coronary_heart_disease_death:_the_Zutphen_study_ L2 - https://academic.oup.com/eurheartj/article-lookup/doi/10.1093/eurheartj/ehn294 DB - PRIME DP - Unbound Medicine ER -