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Targeting multiple neurodegenerative diseases etiologies with multimodal-acting green tea catechins.
J Nutr. 2008 Aug; 138(8):1578S-1583S.JN

Abstract

Green tea is currently considered a source of dietary constituents endowed with biological and pharmacological activities relevant to human health. Human epidemiological and new animal data suggest that the pharmacological benefits of tea drinking may help to protect the brain as we age. Indeed, tea consumption is inversely correlated with the incidence of dementia and Alzheimer's and Parkinson's diseases. In particular, its main catechin polyphenol constituent (-)-epigallocatechin-3-gallate has been shown to exert neuroprotective/neurorescue activities in a wide array of cellular and animal models of neurological disorders. The intense efforts dedicated in recent years to shed light on the molecular mechanisms participating in the brain protective action of green tea indicate that in addition to the known antioxidant activity of catechins, the modulation of signal transduction pathways, cell survival/death genes, and mitochondrial function all contribute significantly to the induction of neuron viability. Because of the multietiological character of neurodegenerative disease pathology, these natural compounds are receiving significant attention as therapeutic cytoprotective agents that simultaneously manipulate multiple desired targets in the central nervous system. This article elaborates on the multimodal activities of green tea polyphenols with emphasis on their recently described neurorescue/neuroregenerative and mitochondrial stabilization actions.

Authors+Show Affiliations

Eve Topf Center for Neurodegenerative Diseases Research and Department of Pharmacology, Faculty of Medicine, Technion, Haifa, Israel. mandel@tx.technion.ac.ilNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18641210

Citation

Mandel, Silvia A., et al. "Targeting Multiple Neurodegenerative Diseases Etiologies With Multimodal-acting Green Tea Catechins." The Journal of Nutrition, vol. 138, no. 8, 2008, 1578S-1583S.
Mandel SA, Amit T, Kalfon L, et al. Targeting multiple neurodegenerative diseases etiologies with multimodal-acting green tea catechins. J Nutr. 2008;138(8):1578S-1583S.
Mandel, S. A., Amit, T., Kalfon, L., Reznichenko, L., & Youdim, M. B. (2008). Targeting multiple neurodegenerative diseases etiologies with multimodal-acting green tea catechins. The Journal of Nutrition, 138(8), 1578S-1583S.
Mandel SA, et al. Targeting Multiple Neurodegenerative Diseases Etiologies With Multimodal-acting Green Tea Catechins. J Nutr. 2008;138(8):1578S-1583S. PubMed PMID: 18641210.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Targeting multiple neurodegenerative diseases etiologies with multimodal-acting green tea catechins. AU - Mandel,Silvia A, AU - Amit,Tamar, AU - Kalfon,Limor, AU - Reznichenko,Lydia, AU - Youdim,Moussa B H, PY - 2008/7/22/pubmed PY - 2008/9/3/medline PY - 2008/7/22/entrez SP - 1578S EP - 1583S JF - The Journal of nutrition JO - J Nutr VL - 138 IS - 8 N2 - Green tea is currently considered a source of dietary constituents endowed with biological and pharmacological activities relevant to human health. Human epidemiological and new animal data suggest that the pharmacological benefits of tea drinking may help to protect the brain as we age. Indeed, tea consumption is inversely correlated with the incidence of dementia and Alzheimer's and Parkinson's diseases. In particular, its main catechin polyphenol constituent (-)-epigallocatechin-3-gallate has been shown to exert neuroprotective/neurorescue activities in a wide array of cellular and animal models of neurological disorders. The intense efforts dedicated in recent years to shed light on the molecular mechanisms participating in the brain protective action of green tea indicate that in addition to the known antioxidant activity of catechins, the modulation of signal transduction pathways, cell survival/death genes, and mitochondrial function all contribute significantly to the induction of neuron viability. Because of the multietiological character of neurodegenerative disease pathology, these natural compounds are receiving significant attention as therapeutic cytoprotective agents that simultaneously manipulate multiple desired targets in the central nervous system. This article elaborates on the multimodal activities of green tea polyphenols with emphasis on their recently described neurorescue/neuroregenerative and mitochondrial stabilization actions. SN - 1541-6100 UR - https://www.unboundmedicine.com/medline/citation/18641210/Targeting_multiple_neurodegenerative_diseases_etiologies_with_multimodal_acting_green_tea_catechins_ DB - PRIME DP - Unbound Medicine ER -