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Quantitative assessment of the degree of villous atrophy in patients with coeliac disease.
J Clin Pathol. 2008 Oct; 61(10):1089-93.JC

Abstract

BACKGROUND

Endoscopy and biopsy are used to diagnose coeliac disease. There are, however, observer-dependent interpretations of the degree of villous atrophy in biopsies. A pilot study using quantitative image-processing procedures was performed to quantify the degree of villous atrophy in patients with coeliac disease.

METHOD

The degree of villous atrophy in duodenal biopsy images was quantified by calculating the ratio of villous edge-to-piecewise arc length (E/P ratio), and this value was compared with the blinded assessment of Marsh score for degree of villous atrophy.

RESULTS

Mean E/P ratios for n = 31 biopsy images, 2.76 (SD 0.44) (Marsh IIIa), 1.91 (0.50) (Marsh IIIb) and 1.18 (0.22) (Marsh IIIc), were significantly different (p = 0.006). Based on non-parametric testing, the E/P ratios were inversely correlated with Marsh scores (Spearman coefficient rho = -0.798, Kendall tau = -0.681; p<0.0001).

CONCLUSIONS

Biopsy images quantified by image analysis correlated exceedingly well with the histopathological grade of villous atrophy. Since quantified measurements are real-numbered values and lack observer bias, measurement of villous atrophy based on image analysis lends itself to standardisation of histological grading.

Authors+Show Affiliations

Department of Pharmacology, Columbia University College of Physicians and Surgeons, New York 10032, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18641407

Citation

Ciaccio, E J., et al. "Quantitative Assessment of the Degree of Villous Atrophy in Patients With Coeliac Disease." Journal of Clinical Pathology, vol. 61, no. 10, 2008, pp. 1089-93.
Ciaccio EJ, Bhagat G, Naiyer AJ, et al. Quantitative assessment of the degree of villous atrophy in patients with coeliac disease. J Clin Pathol. 2008;61(10):1089-93.
Ciaccio, E. J., Bhagat, G., Naiyer, A. J., Hernandez, L., & Green, P. H. (2008). Quantitative assessment of the degree of villous atrophy in patients with coeliac disease. Journal of Clinical Pathology, 61(10), 1089-93. https://doi.org/10.1136/jcp.2008.058669
Ciaccio EJ, et al. Quantitative Assessment of the Degree of Villous Atrophy in Patients With Coeliac Disease. J Clin Pathol. 2008;61(10):1089-93. PubMed PMID: 18641407.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Quantitative assessment of the degree of villous atrophy in patients with coeliac disease. AU - Ciaccio,E J, AU - Bhagat,G, AU - Naiyer,A J, AU - Hernandez,L, AU - Green,P H R, Y1 - 2008/07/19/ PY - 2008/7/22/pubmed PY - 2008/10/22/medline PY - 2008/7/22/entrez SP - 1089 EP - 93 JF - Journal of clinical pathology JO - J Clin Pathol VL - 61 IS - 10 N2 - BACKGROUND: Endoscopy and biopsy are used to diagnose coeliac disease. There are, however, observer-dependent interpretations of the degree of villous atrophy in biopsies. A pilot study using quantitative image-processing procedures was performed to quantify the degree of villous atrophy in patients with coeliac disease. METHOD: The degree of villous atrophy in duodenal biopsy images was quantified by calculating the ratio of villous edge-to-piecewise arc length (E/P ratio), and this value was compared with the blinded assessment of Marsh score for degree of villous atrophy. RESULTS: Mean E/P ratios for n = 31 biopsy images, 2.76 (SD 0.44) (Marsh IIIa), 1.91 (0.50) (Marsh IIIb) and 1.18 (0.22) (Marsh IIIc), were significantly different (p = 0.006). Based on non-parametric testing, the E/P ratios were inversely correlated with Marsh scores (Spearman coefficient rho = -0.798, Kendall tau = -0.681; p<0.0001). CONCLUSIONS: Biopsy images quantified by image analysis correlated exceedingly well with the histopathological grade of villous atrophy. Since quantified measurements are real-numbered values and lack observer bias, measurement of villous atrophy based on image analysis lends itself to standardisation of histological grading. SN - 1472-4146 UR - https://www.unboundmedicine.com/medline/citation/18641407/Quantitative_assessment_of_the_degree_of_villous_atrophy_in_patients_with_coeliac_disease_ L2 - https://jcp.bmj.com/lookup/pmidlookup?view=long&amp;pmid=18641407 DB - PRIME DP - Unbound Medicine ER -