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Mitracarpus frigidus aerial parts exhibited potent antimicrobial, antileishmanial, and antioxidant effects.
Bioresour Technol. 2009 Jan; 100(1):428-33.BT

Abstract

The crude extract and the hexane, CH(2)Cl(2), EtOAc, n-BuOH, and hydromethanolic fractions of the aerial parts of Mitracarpus frigidus were evaluated against promastigote forms of two species of Leishmania (L. chagasi and L. amazonensis), 11 strains of bacteria (Staphylococcus aureus, Pseudomonas aeruginosa, Salmonella enterica sorovar Tythimurium, Shigella sonnei, Klebsiella pneumoniae, Escherichia coli, Micrococcus luteus, Enterococcus faecalis, Enterobacter cloacae, Streptococcus pyogenes and Bacillus cereus) and two yeasts (Candida albicans and Cryptococcus neoformans). The antioxidant activity (DPPH radical scavenging activity and reducing power), cytotoxicity against mammalian cells, and the contents of phenolics and flavonoids were determined. Phytochemical analysis of the major groups of phytoconstituents is also reported. All samples showed antioxidant activity which was positively correlated to the content of phenolic compounds. S. sonnei, B. cereus and C. neoformans were susceptible to all extracts tested, except for the n-BuOH and hydromethanolic fractions, which demonstrated no antimicrobial activity. The lowest MIC was recorded for the CH(2)Cl(2) fraction against C. neoformans (MIC of 10 microg/ml), followed by B. cereus, S. sonnei, and E. cloacae (MIC of 20, 39 and 39 microg/ml, respectively). The CH(2)Cl(2) fraction was the most effective against L. chagasi (IC(50) of 6.7 microg/ml), and the hydromethanolic fraction exhibited the best activity against L. amazonensis (IC(50) of 9 microg/ml). A cytotoxic effect on mammalian cells was observed only for the crude extract and CH(2)Cl(2) fraction at the concentrations of 130 and 31 microg/ml, respectively. These results suggest that M. frigidus has interesting antimicrobial, antileishmanial and antioxidant activities.

Authors+Show Affiliations

Departamento de Bioquímica, ICB, Universidade Federal de Juiz de Fora, Campus Universitário, Martelos, Juiz de Fora, MG, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18644325

Citation

Fabri, R L., et al. "Mitracarpus Frigidus Aerial Parts Exhibited Potent Antimicrobial, Antileishmanial, and Antioxidant Effects." Bioresource Technology, vol. 100, no. 1, 2009, pp. 428-33.
Fabri RL, Nogueira MS, Braga FG, et al. Mitracarpus frigidus aerial parts exhibited potent antimicrobial, antileishmanial, and antioxidant effects. Bioresour Technol. 2009;100(1):428-33.
Fabri, R. L., Nogueira, M. S., Braga, F. G., Coimbra, E. S., & Scio, E. (2009). Mitracarpus frigidus aerial parts exhibited potent antimicrobial, antileishmanial, and antioxidant effects. Bioresource Technology, 100(1), 428-33. https://doi.org/10.1016/j.biortech.2008.05.053
Fabri RL, et al. Mitracarpus Frigidus Aerial Parts Exhibited Potent Antimicrobial, Antileishmanial, and Antioxidant Effects. Bioresour Technol. 2009;100(1):428-33. PubMed PMID: 18644325.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mitracarpus frigidus aerial parts exhibited potent antimicrobial, antileishmanial, and antioxidant effects. AU - Fabri,R L, AU - Nogueira,M S, AU - Braga,F G, AU - Coimbra,E S, AU - Scio,E, Y1 - 2008/07/17/ PY - 2007/05/21/received PY - 2008/04/02/revised PY - 2008/05/17/accepted PY - 2008/7/23/pubmed PY - 2008/12/30/medline PY - 2008/7/23/entrez SP - 428 EP - 33 JF - Bioresource technology JO - Bioresour Technol VL - 100 IS - 1 N2 - The crude extract and the hexane, CH(2)Cl(2), EtOAc, n-BuOH, and hydromethanolic fractions of the aerial parts of Mitracarpus frigidus were evaluated against promastigote forms of two species of Leishmania (L. chagasi and L. amazonensis), 11 strains of bacteria (Staphylococcus aureus, Pseudomonas aeruginosa, Salmonella enterica sorovar Tythimurium, Shigella sonnei, Klebsiella pneumoniae, Escherichia coli, Micrococcus luteus, Enterococcus faecalis, Enterobacter cloacae, Streptococcus pyogenes and Bacillus cereus) and two yeasts (Candida albicans and Cryptococcus neoformans). The antioxidant activity (DPPH radical scavenging activity and reducing power), cytotoxicity against mammalian cells, and the contents of phenolics and flavonoids were determined. Phytochemical analysis of the major groups of phytoconstituents is also reported. All samples showed antioxidant activity which was positively correlated to the content of phenolic compounds. S. sonnei, B. cereus and C. neoformans were susceptible to all extracts tested, except for the n-BuOH and hydromethanolic fractions, which demonstrated no antimicrobial activity. The lowest MIC was recorded for the CH(2)Cl(2) fraction against C. neoformans (MIC of 10 microg/ml), followed by B. cereus, S. sonnei, and E. cloacae (MIC of 20, 39 and 39 microg/ml, respectively). The CH(2)Cl(2) fraction was the most effective against L. chagasi (IC(50) of 6.7 microg/ml), and the hydromethanolic fraction exhibited the best activity against L. amazonensis (IC(50) of 9 microg/ml). A cytotoxic effect on mammalian cells was observed only for the crude extract and CH(2)Cl(2) fraction at the concentrations of 130 and 31 microg/ml, respectively. These results suggest that M. frigidus has interesting antimicrobial, antileishmanial and antioxidant activities. SN - 1873-2976 UR - https://www.unboundmedicine.com/medline/citation/18644325/Mitracarpus_frigidus_aerial_parts_exhibited_potent_antimicrobial_antileishmanial_and_antioxidant_effects_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0960-8524(08)00501-4 DB - PRIME DP - Unbound Medicine ER -