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MDR1 C3435T polymorphism has no influence on developing Helicobacter pylori infection-related gastric cancer and peptic ulcer in Japanese.
Life Sci. 2008 Aug 15; 83(7-8):301-4.LS

Abstract

AIMS

P-glycoprotein, the gene product of multidrug-resistant transporter-1 (MDR1), confers multidrug resistance against antineoplastic agents but also affects the kinetic disposition of some drugs and carcinogens. MDR1 C3435T polymorphism influences the development of colon cancer and adult acute myeloid leukemia by the association with transporting carcinogen. The aim of this study was to clarify the association of MDR1 C3435T polymorphism with susceptibility to gastric cancer and peptic ulcers in patients with Japanese H. pylori infection.

MAIN METHODS

We assessed the MDR1 C3435T polymorphism in H. pylori-positive gastritis alone patients (n=150), gastric cancer (n=292), gastric ulcer (n=215), and duodenal ulcer (n=163) and H. pylori-negative subjects (n=168) as control by a PCR-based method.

KEY FINDINGS

No significant difference existed in frequencies of MDR1 C3435T polymorphisms between H. pylori-negative controls and H. pylori-positive gastritis alone patients. Moreover, MDR1-3435 T allele carriage didn't affect the risk of gastric cancer or peptic ulcer development. The age- and sex-adjusted odds ratios (ORs) of MDR1 3435 T allele carriers relative to the C/C genotype group for gastric cancer, gastric ulcer and duodenal ulcer risk were 0.96 (95%CI: 0.56-1.66), 1.16 (95%CI: 0.72-1.84) and 1.00 (95%CI: 0.61-1.62), respectively.

SIGNIFICANCE

In this preliminary data, the association with MDR1 C3435T polymorphism and risk for developing H. pylori-related gastric cancer and peptic ulcer in Japanese was low. P-glycoprotein might not be involved in the carcinogenesis of H. pylori-related gastric cancer.

Authors+Show Affiliations

First Department of Medicine, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, 431-3192, Japan. sugimoto@bcm.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18644389

Citation

Sugimoto, Mitsushige, et al. "MDR1 C3435T Polymorphism Has No Influence On Developing Helicobacter Pylori Infection-related Gastric Cancer and Peptic Ulcer in Japanese." Life Sciences, vol. 83, no. 7-8, 2008, pp. 301-4.
Sugimoto M, Furuta T, Shirai N, et al. MDR1 C3435T polymorphism has no influence on developing Helicobacter pylori infection-related gastric cancer and peptic ulcer in Japanese. Life Sci. 2008;83(7-8):301-4.
Sugimoto, M., Furuta, T., Shirai, N., Kodaira, C., Nishino, M., Yamade, M., Ikuma, M., Sugimura, H., Ishizaki, T., & Hishida, A. (2008). MDR1 C3435T polymorphism has no influence on developing Helicobacter pylori infection-related gastric cancer and peptic ulcer in Japanese. Life Sciences, 83(7-8), 301-4. https://doi.org/10.1016/j.lfs.2008.06.022
Sugimoto M, et al. MDR1 C3435T Polymorphism Has No Influence On Developing Helicobacter Pylori Infection-related Gastric Cancer and Peptic Ulcer in Japanese. Life Sci. 2008 Aug 15;83(7-8):301-4. PubMed PMID: 18644389.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - MDR1 C3435T polymorphism has no influence on developing Helicobacter pylori infection-related gastric cancer and peptic ulcer in Japanese. AU - Sugimoto,Mitsushige, AU - Furuta,Takahisa, AU - Shirai,Naohito, AU - Kodaira,Chise, AU - Nishino,Masafumi, AU - Yamade,Mihoko, AU - Ikuma,Mutsuhiro, AU - Sugimura,Haruhiko, AU - Ishizaki,Takashi, AU - Hishida,Akira, Y1 - 2008/07/03/ PY - 2008/04/29/received PY - 2008/06/23/revised PY - 2008/06/25/accepted PY - 2008/7/23/pubmed PY - 2008/10/15/medline PY - 2008/7/23/entrez SP - 301 EP - 4 JF - Life sciences JO - Life Sci VL - 83 IS - 7-8 N2 - AIMS: P-glycoprotein, the gene product of multidrug-resistant transporter-1 (MDR1), confers multidrug resistance against antineoplastic agents but also affects the kinetic disposition of some drugs and carcinogens. MDR1 C3435T polymorphism influences the development of colon cancer and adult acute myeloid leukemia by the association with transporting carcinogen. The aim of this study was to clarify the association of MDR1 C3435T polymorphism with susceptibility to gastric cancer and peptic ulcers in patients with Japanese H. pylori infection. MAIN METHODS: We assessed the MDR1 C3435T polymorphism in H. pylori-positive gastritis alone patients (n=150), gastric cancer (n=292), gastric ulcer (n=215), and duodenal ulcer (n=163) and H. pylori-negative subjects (n=168) as control by a PCR-based method. KEY FINDINGS: No significant difference existed in frequencies of MDR1 C3435T polymorphisms between H. pylori-negative controls and H. pylori-positive gastritis alone patients. Moreover, MDR1-3435 T allele carriage didn't affect the risk of gastric cancer or peptic ulcer development. The age- and sex-adjusted odds ratios (ORs) of MDR1 3435 T allele carriers relative to the C/C genotype group for gastric cancer, gastric ulcer and duodenal ulcer risk were 0.96 (95%CI: 0.56-1.66), 1.16 (95%CI: 0.72-1.84) and 1.00 (95%CI: 0.61-1.62), respectively. SIGNIFICANCE: In this preliminary data, the association with MDR1 C3435T polymorphism and risk for developing H. pylori-related gastric cancer and peptic ulcer in Japanese was low. P-glycoprotein might not be involved in the carcinogenesis of H. pylori-related gastric cancer. SN - 0024-3205 UR - https://www.unboundmedicine.com/medline/citation/18644389/MDR1_C3435T_polymorphism_has_no_influence_on_developing_Helicobacter_pylori_infection_related_gastric_cancer_and_peptic_ulcer_in_Japanese_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0024-3205(08)00280-4 DB - PRIME DP - Unbound Medicine ER -