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Metalloproteinases, vascular endothelial growth factor, and angiopoietin 1 and 2 in eutopic and ectopic endometrium.
Fertil Steril. 2009 Jun; 91(6):2315-23.FS

Abstract

OBJECTIVE

To evaluate the expression of vascular endothelial growth factor (VEGF), angiopoietin 1 and 2 (ANGPT1/ANGPT2), and matrix metalloproteinases 1, 2, and 9 (MMP-1, MMP-2, MMP-9) in eutopic and ectopic endometrium.

DESIGN

Experimental retrospective study.

SETTING

University hospital.

PATIENT(S)

Eutopic and ectopic endometrium samples from 30 women with endometriosis and endometrium biopsy samples from 30 healthy women.

INTERVENTION(S)

Biopsies of ovarian endometriomas and eutopic endometrium.

MAIN OUTCOME MEASURE(S)

Immunohistochemical staining to evaluate the expression of VEGF, ANGPT1, ANGPT2, MMP-1, MMP-2, and MMP-9, and real-time polymerase chain reaction analysis to quantify mRNA expression.

RESULT(S)

Patients with endometriosis had higher levels of angiogenic factors and metalloproteinases in endometriotic cysts than in eutopic endometrium. These substances were also overexpressed in eutopic endometrium of patients with endometriosis when compared with normal controls.

CONCLUSION(S)

Overexpression of angiogenic factors and metalloproteinases may be the characteristic feature of endometrium with greater potential to transform into endometriotic lesions in the peritoneal cavity. Structural and/or functional differences of eutopic endometrium could have a role in the pathogenesis of endometriosis secondary to the backward passage of endometrial cells into the peritoneal cavity. Whether these local factors may induce, promote, and/or regulate this transformation remains to be determined.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, University of Naples Federico II, Naples, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18644593

Citation

Di Carlo, Costantino, et al. "Metalloproteinases, Vascular Endothelial Growth Factor, and Angiopoietin 1 and 2 in Eutopic and Ectopic Endometrium." Fertility and Sterility, vol. 91, no. 6, 2009, pp. 2315-23.
Di Carlo C, Bonifacio M, Tommaselli GA, et al. Metalloproteinases, vascular endothelial growth factor, and angiopoietin 1 and 2 in eutopic and ectopic endometrium. Fertil Steril. 2009;91(6):2315-23.
Di Carlo, C., Bonifacio, M., Tommaselli, G. A., Bifulco, G., Guerra, G., & Nappi, C. (2009). Metalloproteinases, vascular endothelial growth factor, and angiopoietin 1 and 2 in eutopic and ectopic endometrium. Fertility and Sterility, 91(6), 2315-23. https://doi.org/10.1016/j.fertnstert.2008.03.079
Di Carlo C, et al. Metalloproteinases, Vascular Endothelial Growth Factor, and Angiopoietin 1 and 2 in Eutopic and Ectopic Endometrium. Fertil Steril. 2009;91(6):2315-23. PubMed PMID: 18644593.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Metalloproteinases, vascular endothelial growth factor, and angiopoietin 1 and 2 in eutopic and ectopic endometrium. AU - Di Carlo,Costantino, AU - Bonifacio,Marika, AU - Tommaselli,Giovanni A, AU - Bifulco,Giuseppe, AU - Guerra,Germano, AU - Nappi,Carmine, Y1 - 2008/07/21/ PY - 2008/01/24/received PY - 2008/03/27/revised PY - 2008/03/27/accepted PY - 2008/7/23/pubmed PY - 2009/7/9/medline PY - 2008/7/23/entrez SP - 2315 EP - 23 JF - Fertility and sterility JO - Fertil. Steril. VL - 91 IS - 6 N2 - OBJECTIVE: To evaluate the expression of vascular endothelial growth factor (VEGF), angiopoietin 1 and 2 (ANGPT1/ANGPT2), and matrix metalloproteinases 1, 2, and 9 (MMP-1, MMP-2, MMP-9) in eutopic and ectopic endometrium. DESIGN: Experimental retrospective study. SETTING: University hospital. PATIENT(S): Eutopic and ectopic endometrium samples from 30 women with endometriosis and endometrium biopsy samples from 30 healthy women. INTERVENTION(S): Biopsies of ovarian endometriomas and eutopic endometrium. MAIN OUTCOME MEASURE(S): Immunohistochemical staining to evaluate the expression of VEGF, ANGPT1, ANGPT2, MMP-1, MMP-2, and MMP-9, and real-time polymerase chain reaction analysis to quantify mRNA expression. RESULT(S): Patients with endometriosis had higher levels of angiogenic factors and metalloproteinases in endometriotic cysts than in eutopic endometrium. These substances were also overexpressed in eutopic endometrium of patients with endometriosis when compared with normal controls. CONCLUSION(S): Overexpression of angiogenic factors and metalloproteinases may be the characteristic feature of endometrium with greater potential to transform into endometriotic lesions in the peritoneal cavity. Structural and/or functional differences of eutopic endometrium could have a role in the pathogenesis of endometriosis secondary to the backward passage of endometrial cells into the peritoneal cavity. Whether these local factors may induce, promote, and/or regulate this transformation remains to be determined. SN - 1556-5653 UR - https://www.unboundmedicine.com/medline/citation/18644593/Metalloproteinases_vascular_endothelial_growth_factor_and_angiopoietin_1_and_2_in_eutopic_and_ectopic_endometrium_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0015-0282(08)00754-1 DB - PRIME DP - Unbound Medicine ER -