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Ultra-pressure liquid chromatography-electrospray tandem mass spectrometry for multiresidue determination of pesticides in water.
J Chromatogr A. 2008 Aug 22; 1202(2):163-72.JC

Abstract

A multiresidue analysis method has been developed for the determination of pesticides in water by ultra-performance liquid chromatography (UPLC) combined with tandem mass spectrometry (MS/MS). The selected pesticides represent a broad range of polarity and volatility [benzoylcyclohexanedione (mesotrione and sulcotrione); chloroacetamide (acetochlor, alachlor, dimethenamide, and metolachlor); phenoxyacetic acid (2,4-D and MCPA); phenoxypropionic (dichloprop and mecoprop); phenylurea (chlortoluron, diuron, isoproturon, linuron, and metoxuron); sulfonylurea (foramsulfuron, iodosulfuron, and nicolsulfuron); triazine (atrazine, cyanazine, desethylatrazine (DEA), desisopropylatrazine (DIA), simazine, and terbutylazine)]. The analytes were extracted using solid-phase extraction (SPE). The separation was carried out on an acquity UPLC BEH C18 column (1.7 microm, 50 mm x 1 mm ID) using a gradient elution profile and mobile phase consisting of 0.1% formic acid in water and acetonitrile. The pesticides were detected with a tandem mass spectrometer after being ionised positively or negatively (depending on the molecule) using an electrospray ionisation (ESI) source. To achieve the suitable extraction conditions for sample preparation, several parameters affecting the efficiency of SPE such as the nature of the sorbent and the eluent, extractant volume and pH were studied. The best recovery was obtained by the extraction with an Oasis HLB cartridge and 3 mL of a solution of acetonitrile/dichloromethane (1:1, v/v) at pH 2. The average recoveries of the pesticides in different samples ranged from 82 to 109%. The weight least squares (WLS) linear regression was used to calculate the limits of detection and quantification (LOD and LOQ) because the dispersion was heteroskedastic. All the pesticides could be correctly quantified at a concentration level of 50 ng L(-1) and most of them could be detected at a concentration inferior or equal to 8 ng L(-1). Efficiency and robustness of this method were evaluated by the analysis of several samples of real natural water.

Authors+Show Affiliations

Laboratoire Sciences Chimiques de Rennes UMR CNRS 6226/ENSCR/UR1, Equipe CIP, Ecole Nationale Supérieure de Chimie de Rennes, avenue du Général Leclerc, 35700 Rennes, France.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18644603

Citation

Gervais, G, et al. "Ultra-pressure Liquid Chromatography-electrospray Tandem Mass Spectrometry for Multiresidue Determination of Pesticides in Water." Journal of Chromatography. A, vol. 1202, no. 2, 2008, pp. 163-72.
Gervais G, Brosillon S, Laplanche A, et al. Ultra-pressure liquid chromatography-electrospray tandem mass spectrometry for multiresidue determination of pesticides in water. J Chromatogr A. 2008;1202(2):163-72.
Gervais, G., Brosillon, S., Laplanche, A., & Helen, C. (2008). Ultra-pressure liquid chromatography-electrospray tandem mass spectrometry for multiresidue determination of pesticides in water. Journal of Chromatography. A, 1202(2), 163-72. https://doi.org/10.1016/j.chroma.2008.07.006
Gervais G, et al. Ultra-pressure Liquid Chromatography-electrospray Tandem Mass Spectrometry for Multiresidue Determination of Pesticides in Water. J Chromatogr A. 2008 Aug 22;1202(2):163-72. PubMed PMID: 18644603.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ultra-pressure liquid chromatography-electrospray tandem mass spectrometry for multiresidue determination of pesticides in water. AU - Gervais,G, AU - Brosillon,S, AU - Laplanche,A, AU - Helen,C, Y1 - 2008/07/09/ PY - 2008/02/05/received PY - 2008/07/02/revised PY - 2008/07/03/accepted PY - 2008/7/23/pubmed PY - 2008/10/11/medline PY - 2008/7/23/entrez SP - 163 EP - 72 JF - Journal of chromatography. A JO - J Chromatogr A VL - 1202 IS - 2 N2 - A multiresidue analysis method has been developed for the determination of pesticides in water by ultra-performance liquid chromatography (UPLC) combined with tandem mass spectrometry (MS/MS). The selected pesticides represent a broad range of polarity and volatility [benzoylcyclohexanedione (mesotrione and sulcotrione); chloroacetamide (acetochlor, alachlor, dimethenamide, and metolachlor); phenoxyacetic acid (2,4-D and MCPA); phenoxypropionic (dichloprop and mecoprop); phenylurea (chlortoluron, diuron, isoproturon, linuron, and metoxuron); sulfonylurea (foramsulfuron, iodosulfuron, and nicolsulfuron); triazine (atrazine, cyanazine, desethylatrazine (DEA), desisopropylatrazine (DIA), simazine, and terbutylazine)]. The analytes were extracted using solid-phase extraction (SPE). The separation was carried out on an acquity UPLC BEH C18 column (1.7 microm, 50 mm x 1 mm ID) using a gradient elution profile and mobile phase consisting of 0.1% formic acid in water and acetonitrile. The pesticides were detected with a tandem mass spectrometer after being ionised positively or negatively (depending on the molecule) using an electrospray ionisation (ESI) source. To achieve the suitable extraction conditions for sample preparation, several parameters affecting the efficiency of SPE such as the nature of the sorbent and the eluent, extractant volume and pH were studied. The best recovery was obtained by the extraction with an Oasis HLB cartridge and 3 mL of a solution of acetonitrile/dichloromethane (1:1, v/v) at pH 2. The average recoveries of the pesticides in different samples ranged from 82 to 109%. The weight least squares (WLS) linear regression was used to calculate the limits of detection and quantification (LOD and LOQ) because the dispersion was heteroskedastic. All the pesticides could be correctly quantified at a concentration level of 50 ng L(-1) and most of them could be detected at a concentration inferior or equal to 8 ng L(-1). Efficiency and robustness of this method were evaluated by the analysis of several samples of real natural water. SN - 0021-9673 UR - https://www.unboundmedicine.com/medline/citation/18644603/Ultra_pressure_liquid_chromatography_electrospray_tandem_mass_spectrometry_for_multiresidue_determination_of_pesticides_in_water_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0021-9673(08)01138-2 DB - PRIME DP - Unbound Medicine ER -