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Bolus ingestion but not regular consumption of native or dealcoholized red wine modulates selected immunological functions of leukocytes in healthy volunteers.

Abstract

BACKGROUND/AIMS

Red wine (RW) consumption reduces the risk for coronary heart disease (CHD). Since immunological mechanisms involved in CHD were modulated by RW polyphenols in vitro, we investigated whether consumption of native or dealcoholized RW (DRW) affects selected immunological parameters in healthy adults ex vivo.

METHODS

Twenty-seven nonsmokers were randomized to consume a single dose of 200 ml RW, 175 ml DRW or 200 ml water (controls). The same doses of RW (n = 24) and DRW (n = 25) were ingested daily for 6 weeks in addition to the subjects' usual diet. Controls (n = 25) did not receive any study drink. Blood was drawn before/90/360 min after supplementation or before and after 6-week intervention, respectively, to determine T cell apoptosis, phagocytosis and burst of neutrophils and monocytes.

RESULTS

T cell apoptosis decreased after 360 min in group DRW [median (interquartile range); t(0): 71 (68; 75)% vs. t(360): 65 (64; 67)%; p = 0.008], but also in controls [t(0): 71 (65; 76)% vs. t(360): 64 (60; 65)%; p = 0.038] and both changes were different from group RW (DRW, p = 0.006; control, p = 0.024). Burst-positive monocytes increased after bolus ingestion of DRW [t(0): 27 (14; 69)% vs. t(360): 47 (29; 74)%; p = 0.012], and this change was different from controls (p = 0.008). Immunological changes related to daily consumption of RW or DRW did not occur.

CONCLUSIONS

Other mechanisms than a modulation of phagocytosis, burst or T cell apoptosis by RW polyphenols, ingested either with or without alcohol, might explain the protective effects of RW against CHD observed in epidemiological studies.

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  • Authors+Show Affiliations

    ,

    FraunhoferInstitute for Molecular Biology and Applied Ecology and Institute of Biology VII (Molecular Biotechnology), RWTH Aachen, Aachen, Germany. ellinger@uni-bonn.de

    , , , ,

    Source

    MeSH

    Adult
    Antioxidants
    Apoptosis
    Coronary Disease
    Dose-Response Relationship, Drug
    Drug Administration Schedule
    Ethanol
    Female
    Flavonoids
    Granulocytes
    Humans
    Male
    Monocytes
    Phagocytosis
    Phenols
    Polyphenols
    Prospective Studies
    Respiratory Burst
    T-Lymphocytes
    Wine

    Pub Type(s)

    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    18645246

    Citation

    Ellinger, Sabine, et al. "Bolus Ingestion but Not Regular Consumption of Native or Dealcoholized Red Wine Modulates Selected Immunological Functions of Leukocytes in Healthy Volunteers." Annals of Nutrition & Metabolism, vol. 52, no. 4, 2008, pp. 288-95.
    Ellinger S, Arendt BM, Fimmers R, et al. Bolus ingestion but not regular consumption of native or dealcoholized red wine modulates selected immunological functions of leukocytes in healthy volunteers. Ann Nutr Metab. 2008;52(4):288-95.
    Ellinger, S., Arendt, B. M., Fimmers, R., Stehle, P., Spengler, U., & Goerlich, R. (2008). Bolus ingestion but not regular consumption of native or dealcoholized red wine modulates selected immunological functions of leukocytes in healthy volunteers. Annals of Nutrition & Metabolism, 52(4), pp. 288-95. doi:10.1159/000146275.
    Ellinger S, et al. Bolus Ingestion but Not Regular Consumption of Native or Dealcoholized Red Wine Modulates Selected Immunological Functions of Leukocytes in Healthy Volunteers. Ann Nutr Metab. 2008;52(4):288-95. PubMed PMID: 18645246.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Bolus ingestion but not regular consumption of native or dealcoholized red wine modulates selected immunological functions of leukocytes in healthy volunteers. AU - Ellinger,Sabine, AU - Arendt,Bianca M, AU - Fimmers,Rolf, AU - Stehle,Peter, AU - Spengler,Ulrich, AU - Goerlich,Roland, Y1 - 2008/07/22/ PY - 2007/08/24/received PY - 2008/04/12/accepted PY - 2008/7/23/pubmed PY - 2008/12/17/medline PY - 2008/7/23/entrez SP - 288 EP - 95 JF - Annals of nutrition & metabolism JO - Ann. Nutr. Metab. VL - 52 IS - 4 N2 - BACKGROUND/AIMS: Red wine (RW) consumption reduces the risk for coronary heart disease (CHD). Since immunological mechanisms involved in CHD were modulated by RW polyphenols in vitro, we investigated whether consumption of native or dealcoholized RW (DRW) affects selected immunological parameters in healthy adults ex vivo. METHODS: Twenty-seven nonsmokers were randomized to consume a single dose of 200 ml RW, 175 ml DRW or 200 ml water (controls). The same doses of RW (n = 24) and DRW (n = 25) were ingested daily for 6 weeks in addition to the subjects' usual diet. Controls (n = 25) did not receive any study drink. Blood was drawn before/90/360 min after supplementation or before and after 6-week intervention, respectively, to determine T cell apoptosis, phagocytosis and burst of neutrophils and monocytes. RESULTS: T cell apoptosis decreased after 360 min in group DRW [median (interquartile range); t(0): 71 (68; 75)% vs. t(360): 65 (64; 67)%; p = 0.008], but also in controls [t(0): 71 (65; 76)% vs. t(360): 64 (60; 65)%; p = 0.038] and both changes were different from group RW (DRW, p = 0.006; control, p = 0.024). Burst-positive monocytes increased after bolus ingestion of DRW [t(0): 27 (14; 69)% vs. t(360): 47 (29; 74)%; p = 0.012], and this change was different from controls (p = 0.008). Immunological changes related to daily consumption of RW or DRW did not occur. CONCLUSIONS: Other mechanisms than a modulation of phagocytosis, burst or T cell apoptosis by RW polyphenols, ingested either with or without alcohol, might explain the protective effects of RW against CHD observed in epidemiological studies. SN - 1421-9697 UR - https://www.unboundmedicine.com/medline/citation/18645246/Bolus_ingestion_but_not_regular_consumption_of_native_or_dealcoholized_red_wine_modulates_selected_immunological_functions_of_leukocytes_in_healthy_volunteers_ L2 - https://www.karger.com?DOI=10.1159/000146275 DB - PRIME DP - Unbound Medicine ER -