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Serum bone Gla protein (BGP) during treatment of hyperthyroidism and hypothyroidism. A longitudinal study.
Horm Metab Res 1991; 23(3):135-8HM

Abstract

Serum bone gamma-carboxyglutamic acid-containing (Gla) protein (BGP) was measured before and with initially 2 weeks, later 4-8 weeks intervals for 20-58 weeks during treatment of patients with hyperthyroidism (n = 10) and hypothyroidism (n = 4). Biochemical euthyroidism was obtained in the hyperthyroid patients after a median of 3 weeks (range 1-8 weeks), and in the hypothyroid patients after a median of 17 weeks (range 10-27 weeks). Serum BGP levels closely followed the thyroid state, being high respectively low in the hyperthyroid and hypothyroid state and reaching a stable plateau just at the time biochemical euthyroidism was obtained. These data suggest that osteoblastic activity is enhanced in hyperthyroidism and reduced in hypothyroidism, and that normalization occurs in close conjunction with the normalization of the thyroid state, without any delay, indicating a direct effect on the function of the excisting osteoblasts by the thyroid hormones.

Authors+Show Affiliations

Department of Medicine E, Frederiksberg Hospital, Copenhagen, Denmark.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1864560

Citation

Faber, J, et al. "Serum Bone Gla Protein (BGP) During Treatment of Hyperthyroidism and Hypothyroidism. a Longitudinal Study." Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme, vol. 23, no. 3, 1991, pp. 135-8.
Faber J, Perrild H, Johansen JS. Serum bone Gla protein (BGP) during treatment of hyperthyroidism and hypothyroidism. A longitudinal study. Horm Metab Res. 1991;23(3):135-8.
Faber, J., Perrild, H., & Johansen, J. S. (1991). Serum bone Gla protein (BGP) during treatment of hyperthyroidism and hypothyroidism. A longitudinal study. Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme, 23(3), pp. 135-8.
Faber J, Perrild H, Johansen JS. Serum Bone Gla Protein (BGP) During Treatment of Hyperthyroidism and Hypothyroidism. a Longitudinal Study. Horm Metab Res. 1991;23(3):135-8. PubMed PMID: 1864560.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum bone Gla protein (BGP) during treatment of hyperthyroidism and hypothyroidism. A longitudinal study. AU - Faber,J, AU - Perrild,H, AU - Johansen,J S, PY - 1991/3/1/pubmed PY - 1991/3/1/medline PY - 1991/3/1/entrez SP - 135 EP - 8 JF - Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme JO - Horm. Metab. Res. VL - 23 IS - 3 N2 - Serum bone gamma-carboxyglutamic acid-containing (Gla) protein (BGP) was measured before and with initially 2 weeks, later 4-8 weeks intervals for 20-58 weeks during treatment of patients with hyperthyroidism (n = 10) and hypothyroidism (n = 4). Biochemical euthyroidism was obtained in the hyperthyroid patients after a median of 3 weeks (range 1-8 weeks), and in the hypothyroid patients after a median of 17 weeks (range 10-27 weeks). Serum BGP levels closely followed the thyroid state, being high respectively low in the hyperthyroid and hypothyroid state and reaching a stable plateau just at the time biochemical euthyroidism was obtained. These data suggest that osteoblastic activity is enhanced in hyperthyroidism and reduced in hypothyroidism, and that normalization occurs in close conjunction with the normalization of the thyroid state, without any delay, indicating a direct effect on the function of the excisting osteoblasts by the thyroid hormones. SN - 0018-5043 UR - https://www.unboundmedicine.com/medline/citation/1864560/Serum_bone_Gla_protein__BGP__during_treatment_of_hyperthyroidism_and_hypothyroidism__A_longitudinal_study_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2007-1003633 DB - PRIME DP - Unbound Medicine ER -