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[Efficacy of the amodiaquine+sulfadoxine-pyrimethamine combination and of chloroquine for the treatment of malaria in Córdoba, Colombia, 2006].
Biomedica. 2008 Mar; 28(1):148-59.B

Abstract

INTRODUCTION

The decrease in the efficacy of antimalarial drugs in the world and in Colombia hampers its control.

OBJECTIVE

The in vivo therapeutic efficacy of the amodiaquine+sulfadoxine-pyrimethamine combination was evaluated in the treatment of uncomplicated Plasmodium falciparum malaria and of chloroquine for P. vivax malaria.

MATERIALS AND METHODS

From May to November 2006, in vivo efficacy studies of malaria treatments were undertaken in Tierralta, Córdoba, northeastern Colombia. Standard protocols were followed as recommended by the World Health Organization/Panamerican Health Organization, with some modifications. Patients older than two years with single P. falciparum or P. vivax infection, with asexual parasitemia between 500 and 50,000 parasites/microl, were selected according to established inclusion and exclusion criteria. Supervised treatment was administered, and clinical and parasitological follow-up was carried out on days 0 (inclusion), 1, 2, 3, 7, 14, 21 and 28. The outcome was defined as adequate clinical and parasitological response, early therapeutic failure, or late therapeutic failure.

RESULTS

Of 53 subjects selected, 50 (94.3%; CI 70%-100%) presented adequate clinical and parasitological response to the amodiaquine+sulfadoxine-pyrimethamine treatment for uncomplicated falciparum malaria. One patient presented early therapeutic failure, and two developed late therapeutic failure. All of the 50 patients (95%CI: 74%-100%) in the invivo efficacy study of chloroquine for vivax malaria presented adequate clinical and parasitological response.

CONCLUSION

In Cordoba, the amodiaquine+sulfadoxine-pyrimethamine combination and chloroquine show a high efficacy for the treatment of uncomplicated falciparum and vivax malaria, respectively.

Authors+Show Affiliations

Grupo de Parasitología, Instituto Nacional de Salud, Bogotá, D.C, Colombia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

spa

PubMed ID

18645670

Citation

Pérez, Manuel Alberto, et al. "[Efficacy of the Amodiaquine+sulfadoxine-pyrimethamine Combination and of Chloroquine for the Treatment of Malaria in Córdoba, Colombia, 2006]." Biomedica : Revista Del Instituto Nacional De Salud, vol. 28, no. 1, 2008, pp. 148-59.
Pérez MA, Cortés LJ, Guerra AP, et al. [Efficacy of the amodiaquine+sulfadoxine-pyrimethamine combination and of chloroquine for the treatment of malaria in Córdoba, Colombia, 2006]. Biomedica. 2008;28(1):148-59.
Pérez, M. A., Cortés, L. J., Guerra, A. P., Knudson, A., Usta, C., & Nicholls, R. S. (2008). [Efficacy of the amodiaquine+sulfadoxine-pyrimethamine combination and of chloroquine for the treatment of malaria in Córdoba, Colombia, 2006]. Biomedica : Revista Del Instituto Nacional De Salud, 28(1), 148-59.
Pérez MA, et al. [Efficacy of the Amodiaquine+sulfadoxine-pyrimethamine Combination and of Chloroquine for the Treatment of Malaria in Córdoba, Colombia, 2006]. Biomedica. 2008;28(1):148-59. PubMed PMID: 18645670.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Efficacy of the amodiaquine+sulfadoxine-pyrimethamine combination and of chloroquine for the treatment of malaria in Córdoba, Colombia, 2006]. AU - Pérez,Manuel Alberto, AU - Cortés,Liliana Jazmín, AU - Guerra,Angela Patricia, AU - Knudson,Angélica, AU - Usta,Carlos, AU - Nicholls,Rubén Santiago, PY - 2007/06/28/received PY - 2007/11/14/accepted PY - 2008/7/23/pubmed PY - 2008/11/5/medline PY - 2008/7/23/entrez SP - 148 EP - 59 JF - Biomedica : revista del Instituto Nacional de Salud JO - Biomedica VL - 28 IS - 1 N2 - INTRODUCTION: The decrease in the efficacy of antimalarial drugs in the world and in Colombia hampers its control. OBJECTIVE: The in vivo therapeutic efficacy of the amodiaquine+sulfadoxine-pyrimethamine combination was evaluated in the treatment of uncomplicated Plasmodium falciparum malaria and of chloroquine for P. vivax malaria. MATERIALS AND METHODS: From May to November 2006, in vivo efficacy studies of malaria treatments were undertaken in Tierralta, Córdoba, northeastern Colombia. Standard protocols were followed as recommended by the World Health Organization/Panamerican Health Organization, with some modifications. Patients older than two years with single P. falciparum or P. vivax infection, with asexual parasitemia between 500 and 50,000 parasites/microl, were selected according to established inclusion and exclusion criteria. Supervised treatment was administered, and clinical and parasitological follow-up was carried out on days 0 (inclusion), 1, 2, 3, 7, 14, 21 and 28. The outcome was defined as adequate clinical and parasitological response, early therapeutic failure, or late therapeutic failure. RESULTS: Of 53 subjects selected, 50 (94.3%; CI 70%-100%) presented adequate clinical and parasitological response to the amodiaquine+sulfadoxine-pyrimethamine treatment for uncomplicated falciparum malaria. One patient presented early therapeutic failure, and two developed late therapeutic failure. All of the 50 patients (95%CI: 74%-100%) in the invivo efficacy study of chloroquine for vivax malaria presented adequate clinical and parasitological response. CONCLUSION: In Cordoba, the amodiaquine+sulfadoxine-pyrimethamine combination and chloroquine show a high efficacy for the treatment of uncomplicated falciparum and vivax malaria, respectively. SN - 0120-4157 UR - https://www.unboundmedicine.com/medline/citation/18645670/[Efficacy_of_the_amodiaquine+sulfadoxine_pyrimethamine_combination_and_of_chloroquine_for_the_treatment_of_malaria_in_Córdoba_Colombia_2006]_ L2 - http://www.diseaseinfosearch.org/result/4415 DB - PRIME DP - Unbound Medicine ER -