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Abnormal response of insulin to glucose loading and assessment of insulin resistance in non-obese patients with polycystic ovary syndrome.
Gynecol Endocrinol. 2008 Jul; 24(7):385-91.GE

Abstract

OBJECTIVES

To investigate the insulin response to glucose loading and to determine which method is best in order to evaluate insulin resistance in women with polycystic ovary syndrome (PCOS).

METHODS

In order to eliminate the influence of obesity on the variables, all subjects were non-obese. Standard oral glucose tolerance tests were performed in 23 normal women and 21 patients with PCOS. Insulin resistance was evaluated by the homeostasis model assessment insulin resistance index (HOMA-IR), homeostasis model assessment for beta-cell function (HOMA-%B), the quantitative insulin-sensitivity check index (QUICKI) and area under the curve for glucose (AUC(glucose)) and insulin (AUC(insulin)).

RESULTS

The mean values of HOMA-IR, AUC(insulin) and AUC(glucose) in the PCOS group were significantly higher than in the BMI-matched normal control group (p < 0.05, p < 0.01 and p < 0.01, respectively). There were significant positive correlations between AUC(insulin) and AUC(glucose) and androgens or luteinizing hormone in all subjects (p < 0.001). However, HOMA-IR and fasting insulin were significantly correlated only with total testosterone (p < 0.05). AUC(insulin) and AUC(glucose) values were elevated in more than 50% of PCOS patients with normal values of HOMA indices.

CONCLUSION

In the PCOS group, the abnormal response of insulin to glucose loading was suggested. AUC(insulin) may be a better index than others to evaluate insulin resistance in non-obese PCOS patients.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Tokyo, Japan. takeuchi-dis@h.u-tokyo.ac.jpNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18645711

Citation

Takeuchi, Toru, et al. "Abnormal Response of Insulin to Glucose Loading and Assessment of Insulin Resistance in Non-obese Patients With Polycystic Ovary Syndrome." Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, vol. 24, no. 7, 2008, pp. 385-91.
Takeuchi T, Tsutsumi O, Taketani Y. Abnormal response of insulin to glucose loading and assessment of insulin resistance in non-obese patients with polycystic ovary syndrome. Gynecol Endocrinol. 2008;24(7):385-91.
Takeuchi, T., Tsutsumi, O., & Taketani, Y. (2008). Abnormal response of insulin to glucose loading and assessment of insulin resistance in non-obese patients with polycystic ovary syndrome. Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, 24(7), 385-91. https://doi.org/10.1080/09513590802173584
Takeuchi T, Tsutsumi O, Taketani Y. Abnormal Response of Insulin to Glucose Loading and Assessment of Insulin Resistance in Non-obese Patients With Polycystic Ovary Syndrome. Gynecol Endocrinol. 2008;24(7):385-91. PubMed PMID: 18645711.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Abnormal response of insulin to glucose loading and assessment of insulin resistance in non-obese patients with polycystic ovary syndrome. AU - Takeuchi,Toru, AU - Tsutsumi,Osamu, AU - Taketani,Yuji, PY - 2008/7/23/pubmed PY - 2008/9/5/medline PY - 2008/7/23/entrez SP - 385 EP - 91 JF - Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology JO - Gynecol. Endocrinol. VL - 24 IS - 7 N2 - OBJECTIVES: To investigate the insulin response to glucose loading and to determine which method is best in order to evaluate insulin resistance in women with polycystic ovary syndrome (PCOS). METHODS: In order to eliminate the influence of obesity on the variables, all subjects were non-obese. Standard oral glucose tolerance tests were performed in 23 normal women and 21 patients with PCOS. Insulin resistance was evaluated by the homeostasis model assessment insulin resistance index (HOMA-IR), homeostasis model assessment for beta-cell function (HOMA-%B), the quantitative insulin-sensitivity check index (QUICKI) and area under the curve for glucose (AUC(glucose)) and insulin (AUC(insulin)). RESULTS: The mean values of HOMA-IR, AUC(insulin) and AUC(glucose) in the PCOS group were significantly higher than in the BMI-matched normal control group (p < 0.05, p < 0.01 and p < 0.01, respectively). There were significant positive correlations between AUC(insulin) and AUC(glucose) and androgens or luteinizing hormone in all subjects (p < 0.001). However, HOMA-IR and fasting insulin were significantly correlated only with total testosterone (p < 0.05). AUC(insulin) and AUC(glucose) values were elevated in more than 50% of PCOS patients with normal values of HOMA indices. CONCLUSION: In the PCOS group, the abnormal response of insulin to glucose loading was suggested. AUC(insulin) may be a better index than others to evaluate insulin resistance in non-obese PCOS patients. SN - 1473-0766 UR - https://www.unboundmedicine.com/medline/citation/18645711/Abnormal_response_of_insulin_to_glucose_loading_and_assessment_of_insulin_resistance_in_non_obese_patients_with_polycystic_ovary_syndrome_ L2 - http://www.tandfonline.com/doi/full/10.1080/09513590802173584 DB - PRIME DP - Unbound Medicine ER -