Tags

Type your tag names separated by a space and hit enter

Plasma advanced glycation end products are decreased in obese children compared with lean controls.
Int J Pediatr Obes. 2009; 4(2):112-8.IJ

Abstract

OBJECTIVE

In obesity, the combined effects of enhanced food consumption, enhanced oxidative stress and microinflammation could augment the advanced glycation end products (AGEs) accumulation in plasma. We compared the plasma concentrations of AGEs and the soluble receptor for AGEs (sRAGE) in relation to markers of oxidative stress, microinflammation and renal function in obese and lean children/adolescents.

METHODS

In 18 apparently healthy obese children/adolescents (7 females/11 males; age: 5-18 years; body mass index, BMI: 27.3+/-3.3 kg/m2) and 18 healthy lean controls (10 females/8 males; age: 4-17 years, BMI: 22.4+/-2.1 kg/m2) the plasma concentration of N(epsilon)-carboxymethyllysine (CML), fructoselysine (FL), AGE-associated fluorescence, sRAGE, high sensitive-C-reactive protein (hsCRP), interleukin-6 (IL-6) and urinary 8-hydroxy-2-deoxyguanosine (U-8-OHdG) excretion, plasma advanced oxidation protein products (AOPPs), renal function, and the HOMA index of insulin resistance were determined.

RESULTS

Obese children/adolescents had significantly lower concentrations of plasma FL (6.8+/-0.3 mmol/mol lysine vs. 7.7+/-0.3, p<0.02), CML (0.14+/-0.03 mmol/mol lysine vs. 0.22+/-0.04, p<0.001), and fluorescent AGEs (223+/-37 arbitrary units (AU) vs. 318+/-64, p<0.01) than their lean counterparts. Plasma sRAGE concentration did not differ (2.3+/-0.6 ng/ml vs. 2.6+/-0.6). Obese children/adolescents were more insulin-resistant (HOMA index: p<0.01), exhibited higher levels of markers of inflammation (hs-CRP: p<0.03; IL-6: p<0.02), of oxidative stress (AOPPs: p<0.05; 8-OHdG: p<0.04) and had a higher creatinine clearance (p<0.01) and proteinuria (p<0.01).

CONCLUSIONS

We present the first evidence that childhood/adolescent obesity is characterized by lower plasma AGE levels, despite lower insulin sensitivity, enhanced oxidative stress and microinflammation. An enhanced removal of AGE peptides via hyperfiltration may partially contribute to the lower plasma AGE levels.

Authors+Show Affiliations

Department of Clinical and Experimental Pharmacotherapy, Slovak Medical University, Limbová 14, Bratislava 833 03, Slovakia. katarina.sebekova@szu.skNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18645732

Citation

Sebeková, Katarĺna, et al. "Plasma Advanced Glycation End Products Are Decreased in Obese Children Compared With Lean Controls." International Journal of Pediatric Obesity : IJPO : an Official Journal of the International Association for the Study of Obesity, vol. 4, no. 2, 2009, pp. 112-8.
Sebeková K, Somoza V, Jarcusková M, et al. Plasma advanced glycation end products are decreased in obese children compared with lean controls. Int J Pediatr Obes. 2009;4(2):112-8.
Sebeková, K., Somoza, V., Jarcusková, M., Heidland, A., & Podracká, L. (2009). Plasma advanced glycation end products are decreased in obese children compared with lean controls. International Journal of Pediatric Obesity : IJPO : an Official Journal of the International Association for the Study of Obesity, 4(2), 112-8. https://doi.org/10.1080/17477160802248039
Sebeková K, et al. Plasma Advanced Glycation End Products Are Decreased in Obese Children Compared With Lean Controls. Int J Pediatr Obes. 2009;4(2):112-8. PubMed PMID: 18645732.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma advanced glycation end products are decreased in obese children compared with lean controls. AU - Sebeková,Katarĺna, AU - Somoza,Veronika, AU - Jarcusková,Monika, AU - Heidland,August, AU - Podracká,Ludmila, PY - 2008/7/23/pubmed PY - 2009/6/25/medline PY - 2008/7/23/entrez SP - 112 EP - 8 JF - International journal of pediatric obesity : IJPO : an official journal of the International Association for the Study of Obesity JO - Int J Pediatr Obes VL - 4 IS - 2 N2 - OBJECTIVE: In obesity, the combined effects of enhanced food consumption, enhanced oxidative stress and microinflammation could augment the advanced glycation end products (AGEs) accumulation in plasma. We compared the plasma concentrations of AGEs and the soluble receptor for AGEs (sRAGE) in relation to markers of oxidative stress, microinflammation and renal function in obese and lean children/adolescents. METHODS: In 18 apparently healthy obese children/adolescents (7 females/11 males; age: 5-18 years; body mass index, BMI: 27.3+/-3.3 kg/m2) and 18 healthy lean controls (10 females/8 males; age: 4-17 years, BMI: 22.4+/-2.1 kg/m2) the plasma concentration of N(epsilon)-carboxymethyllysine (CML), fructoselysine (FL), AGE-associated fluorescence, sRAGE, high sensitive-C-reactive protein (hsCRP), interleukin-6 (IL-6) and urinary 8-hydroxy-2-deoxyguanosine (U-8-OHdG) excretion, plasma advanced oxidation protein products (AOPPs), renal function, and the HOMA index of insulin resistance were determined. RESULTS: Obese children/adolescents had significantly lower concentrations of plasma FL (6.8+/-0.3 mmol/mol lysine vs. 7.7+/-0.3, p<0.02), CML (0.14+/-0.03 mmol/mol lysine vs. 0.22+/-0.04, p<0.001), and fluorescent AGEs (223+/-37 arbitrary units (AU) vs. 318+/-64, p<0.01) than their lean counterparts. Plasma sRAGE concentration did not differ (2.3+/-0.6 ng/ml vs. 2.6+/-0.6). Obese children/adolescents were more insulin-resistant (HOMA index: p<0.01), exhibited higher levels of markers of inflammation (hs-CRP: p<0.03; IL-6: p<0.02), of oxidative stress (AOPPs: p<0.05; 8-OHdG: p<0.04) and had a higher creatinine clearance (p<0.01) and proteinuria (p<0.01). CONCLUSIONS: We present the first evidence that childhood/adolescent obesity is characterized by lower plasma AGE levels, despite lower insulin sensitivity, enhanced oxidative stress and microinflammation. An enhanced removal of AGE peptides via hyperfiltration may partially contribute to the lower plasma AGE levels. SN - 1747-7174 UR - https://www.unboundmedicine.com/medline/citation/18645732/Plasma_advanced_glycation_end_products_are_decreased_in_obese_children_compared_with_lean_controls_ L2 - https://doi.org/10.1080/17477160802248039 DB - PRIME DP - Unbound Medicine ER -