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Interaction between PPARG Pro12Ala and ADIPOQ G276T concerning cholesterol levels in childhood obesity.
Int J Pediatr Obes. 2009; 4(2):119-25.IJ

Abstract

AIM

The aim of this study was to investigate the role of two candidate gene polymorphisms for insulin resistance and lipid levels in obese children and adolescents.

METHODS

Two markers of insulin resistance and lipid levels, Pro12Ala in peroxisome proliferator-activated receptor-gamma2 (PPARG) and G276T in adiponectin (ADIPOQ), were genotyped in 285 obese children and adolescents. As the apolipoprotein E (APOE) polymorphisms C112R and R158C are known to have a profound impact on lipid levels in both children and adults, results were adjusted for APOE genotype.

RESULTS

We found no association for PPARG or ADIPOQ polymorphisms with Body Mass Index (BMI), High Density Lipoprotein (HDL)-cholesterol, triglycerides or Insulin Resistance estimated by Homeostasis Model of Assessment (HOMA-IR). Wild type carriers of PPARG Pro12Ala (p<0.05), homozygous carriers of the variant allele of ADIPOQ G276T (p<0.001) and epsilon4 carriers of APOE (p<0.001) had higher total and low density lipoprotein (LDL)-cholesterol levels adjusted for age, gender, BMI and insulin sensitivity. A PPARG/ADIPOQ risk genotype combination was identified by analysis of covariance (ANCOVA) comparing all existing combinations. Carriers of PPARG Pro/Pro and ADIPOQ 276 T/T had higher total (5.0 [4.1-5.8] vs. 4.1 [3.6-4.6] mmol/l) and LDL-cholesterol levels (3.7 [2.9-4.5] vs. 3.0 [2.5-3.5] mmol/l) compared with carriers of other combinations (p<0.001). Importantly, the PPARG and ADIPOQ associations were unaffected when adjusting for APOE genotype.

CONCLUSIONS

Genetic variants in candidate genes for insulin resistance are associated with cholesterol levels in obese children and adolescents, and may offer additional information in the risk assessment of obese children.

Authors+Show Affiliations

Department of Clinical Sciences Malmö, Clinical Obesity, Lund University, CRC, UMAS, Ing 72, Hus 91, Plan 12, Malmö S-205 02, Sweden. lovisa.johansson@med.lu.seNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18645733

Citation

Johansson, Lovisa E., et al. "Interaction Between PPARG Pro12Ala and ADIPOQ G276T Concerning Cholesterol Levels in Childhood Obesity." International Journal of Pediatric Obesity : IJPO : an Official Journal of the International Association for the Study of Obesity, vol. 4, no. 2, 2009, pp. 119-25.
Johansson LE, Danielsson P, Norgren S, et al. Interaction between PPARG Pro12Ala and ADIPOQ G276T concerning cholesterol levels in childhood obesity. Int J Pediatr Obes. 2009;4(2):119-25.
Johansson, L. E., Danielsson, P., Norgren, S., Marcus, C., & Ridderstråle, M. (2009). Interaction between PPARG Pro12Ala and ADIPOQ G276T concerning cholesterol levels in childhood obesity. International Journal of Pediatric Obesity : IJPO : an Official Journal of the International Association for the Study of Obesity, 4(2), 119-25. https://doi.org/10.1080/17477160802263194
Johansson LE, et al. Interaction Between PPARG Pro12Ala and ADIPOQ G276T Concerning Cholesterol Levels in Childhood Obesity. Int J Pediatr Obes. 2009;4(2):119-25. PubMed PMID: 18645733.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Interaction between PPARG Pro12Ala and ADIPOQ G276T concerning cholesterol levels in childhood obesity. AU - Johansson,Lovisa E, AU - Danielsson,Pernilla, AU - Norgren,Svante, AU - Marcus,Claude, AU - Ridderstråle,Martin, PY - 2008/7/23/pubmed PY - 2009/6/25/medline PY - 2008/7/23/entrez SP - 119 EP - 25 JF - International journal of pediatric obesity : IJPO : an official journal of the International Association for the Study of Obesity JO - Int J Pediatr Obes VL - 4 IS - 2 N2 - AIM: The aim of this study was to investigate the role of two candidate gene polymorphisms for insulin resistance and lipid levels in obese children and adolescents. METHODS: Two markers of insulin resistance and lipid levels, Pro12Ala in peroxisome proliferator-activated receptor-gamma2 (PPARG) and G276T in adiponectin (ADIPOQ), were genotyped in 285 obese children and adolescents. As the apolipoprotein E (APOE) polymorphisms C112R and R158C are known to have a profound impact on lipid levels in both children and adults, results were adjusted for APOE genotype. RESULTS: We found no association for PPARG or ADIPOQ polymorphisms with Body Mass Index (BMI), High Density Lipoprotein (HDL)-cholesterol, triglycerides or Insulin Resistance estimated by Homeostasis Model of Assessment (HOMA-IR). Wild type carriers of PPARG Pro12Ala (p<0.05), homozygous carriers of the variant allele of ADIPOQ G276T (p<0.001) and epsilon4 carriers of APOE (p<0.001) had higher total and low density lipoprotein (LDL)-cholesterol levels adjusted for age, gender, BMI and insulin sensitivity. A PPARG/ADIPOQ risk genotype combination was identified by analysis of covariance (ANCOVA) comparing all existing combinations. Carriers of PPARG Pro/Pro and ADIPOQ 276 T/T had higher total (5.0 [4.1-5.8] vs. 4.1 [3.6-4.6] mmol/l) and LDL-cholesterol levels (3.7 [2.9-4.5] vs. 3.0 [2.5-3.5] mmol/l) compared with carriers of other combinations (p<0.001). Importantly, the PPARG and ADIPOQ associations were unaffected when adjusting for APOE genotype. CONCLUSIONS: Genetic variants in candidate genes for insulin resistance are associated with cholesterol levels in obese children and adolescents, and may offer additional information in the risk assessment of obese children. SN - 1747-7174 UR - https://www.unboundmedicine.com/medline/citation/18645733/Interaction_between_PPARG_Pro12Ala_and_ADIPOQ_G276T_concerning_cholesterol_levels_in_childhood_obesity_ L2 - https://doi.org/10.1080/17477160802263194 DB - PRIME DP - Unbound Medicine ER -