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[The target plasma concentration of propofol required to induce electroencephalography burst suppression with target-controlled infusion].
Zhonghua Yi Xue Za Zhi. 2008 Mar 04; 88(9):587-90.ZY

Abstract

OBJECTIVE

To determine the optimal target plasma concentration of propofol required to induce EEG burst suppression administered by TCI in order to decrease cerebral metabolic rate and increase tolerance to cerebral ischemia and hypoxia.

METHODS

One hundred and fifty ASA I-II patients(aged 18-55 years-old, BMI < 30, Mallampati Score I-II) scheduled for elective surgery undergoing general anesthesia were enrolled in this study. Patients with systemic diseases or other factors effecting the electrical activity of brain were excluded. ECG, IBP, SpO2, PetCO2, Temperature and EEG (two-channel referential montage system) were continuously monitored during the procedure. Patients were induced with TCI propofol (the target plasma concentration was initially set at 5.4 microg/ml), After induction and intubation, target plasma concentration was increased by 0.3 microg/ml increment and sustained 15 minutes until EEG burst suppression appeared(stable burst suppression waveform and BSR > 50%), and this target concentration was recorded.

RESULTS

The mean target plasma concentration of propofol with TCI required to induce EEG burst suppression was 6.1 +/- 0.6 microg/ml with 95% confidence interval of 5.99-6.19 microg/ml. There was no significant difference between the genders.

CONCLUSIONS

The target plasma concentration of propofol reached 6.2 microg/ml can induce EEG burst suppression, which is better for intraoperative cerebral protection.

Authors+Show Affiliations

Department of Anesthesiology, Huashan Hospital, Fudan University, Shanghai 200040, China.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
English Abstract
Journal Article

Language

chi

PubMed ID

18646710

Citation

Wang, Zhuo-qun, et al. "[The Target Plasma Concentration of Propofol Required to Induce Electroencephalography Burst Suppression With Target-controlled Infusion]." Zhonghua Yi Xue Za Zhi, vol. 88, no. 9, 2008, pp. 587-90.
Wang ZQ, Gu HH, Liang WM. [The target plasma concentration of propofol required to induce electroencephalography burst suppression with target-controlled infusion]. Zhonghua Yi Xue Za Zhi. 2008;88(9):587-90.
Wang, Z. Q., Gu, H. H., & Liang, W. M. (2008). [The target plasma concentration of propofol required to induce electroencephalography burst suppression with target-controlled infusion]. Zhonghua Yi Xue Za Zhi, 88(9), 587-90.
Wang ZQ, Gu HH, Liang WM. [The Target Plasma Concentration of Propofol Required to Induce Electroencephalography Burst Suppression With Target-controlled Infusion]. Zhonghua Yi Xue Za Zhi. 2008 Mar 4;88(9):587-90. PubMed PMID: 18646710.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The target plasma concentration of propofol required to induce electroencephalography burst suppression with target-controlled infusion]. AU - Wang,Zhuo-qun, AU - Gu,Hua-hua, AU - Liang,Wei-min, PY - 2008/7/24/pubmed PY - 2008/12/23/medline PY - 2008/7/24/entrez SP - 587 EP - 90 JF - Zhonghua yi xue za zhi JO - Zhonghua Yi Xue Za Zhi VL - 88 IS - 9 N2 - OBJECTIVE: To determine the optimal target plasma concentration of propofol required to induce EEG burst suppression administered by TCI in order to decrease cerebral metabolic rate and increase tolerance to cerebral ischemia and hypoxia. METHODS: One hundred and fifty ASA I-II patients(aged 18-55 years-old, BMI < 30, Mallampati Score I-II) scheduled for elective surgery undergoing general anesthesia were enrolled in this study. Patients with systemic diseases or other factors effecting the electrical activity of brain were excluded. ECG, IBP, SpO2, PetCO2, Temperature and EEG (two-channel referential montage system) were continuously monitored during the procedure. Patients were induced with TCI propofol (the target plasma concentration was initially set at 5.4 microg/ml), After induction and intubation, target plasma concentration was increased by 0.3 microg/ml increment and sustained 15 minutes until EEG burst suppression appeared(stable burst suppression waveform and BSR > 50%), and this target concentration was recorded. RESULTS: The mean target plasma concentration of propofol with TCI required to induce EEG burst suppression was 6.1 +/- 0.6 microg/ml with 95% confidence interval of 5.99-6.19 microg/ml. There was no significant difference between the genders. CONCLUSIONS: The target plasma concentration of propofol reached 6.2 microg/ml can induce EEG burst suppression, which is better for intraoperative cerebral protection. SN - 0376-2491 UR - https://www.unboundmedicine.com/medline/citation/18646710/[The_target_plasma_concentration_of_propofol_required_to_induce_electroencephalography_burst_suppression_with_target_controlled_infusion]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&amp;issn=0376-2491&amp;year=2008&amp;vol=88&amp;issue=9&amp;fpage=587 DB - PRIME DP - Unbound Medicine ER -