Abstract
Nature has perfected the stereospecific aldol reaction by using aldolase enzymes. While virtually all the biochemical aldol reactions use unmodified donor and acceptor carbonyls and take place under catalytic control in an aqueous environment, the chemical domain of the aldol addition has mostly relied on prior transformation of carbonyl substrates, and the whole process traditionally is carried out in anhydrous solvents. The area of aqua-asymmetric aldol reactions has received much attention recently in light of the perception both of its green chemistry advantages and its analogy to eon-perfected enzyme catalysis. Both chiral metal complexes and small chiral organic molecules have been recently reported to catalyze aldol reactions with relatively high chemical and stereochemical efficiency. This tutorial review describes recent developments in this area.
TY - JOUR
T1 - Catalytic asymmetric aldol reactions in aqueous media.
AU - Mlynarski,Jacek,
AU - Paradowska,Joanna,
Y1 - 2008/06/09/
PY - 2008/7/24/pubmed
PY - 2008/10/3/medline
PY - 2008/7/24/entrez
SP - 1502
EP - 11
JF - Chemical Society reviews
JO - Chem Soc Rev
VL - 37
IS - 8
N2 - Nature has perfected the stereospecific aldol reaction by using aldolase enzymes. While virtually all the biochemical aldol reactions use unmodified donor and acceptor carbonyls and take place under catalytic control in an aqueous environment, the chemical domain of the aldol addition has mostly relied on prior transformation of carbonyl substrates, and the whole process traditionally is carried out in anhydrous solvents. The area of aqua-asymmetric aldol reactions has received much attention recently in light of the perception both of its green chemistry advantages and its analogy to eon-perfected enzyme catalysis. Both chiral metal complexes and small chiral organic molecules have been recently reported to catalyze aldol reactions with relatively high chemical and stereochemical efficiency. This tutorial review describes recent developments in this area.
SN - 0306-0012
UR - https://www.unboundmedicine.com/medline/citation/18648676/Catalytic_asymmetric_aldol_reactions_in_aqueous_media_
L2 - https://doi.org/10.1039/b710577k
DB - PRIME
DP - Unbound Medicine
ER -