Catalytic asymmetric aldol reactions in aqueous media.
Chem Soc Rev. 2008 Aug; 37(8):1502-11.CS

Abstract

Nature has perfected the stereospecific aldol reaction by using aldolase enzymes. While virtually all the biochemical aldol reactions use unmodified donor and acceptor carbonyls and take place under catalytic control in an aqueous environment, the chemical domain of the aldol addition has mostly relied on prior transformation of carbonyl substrates, and the whole process traditionally is carried out in anhydrous solvents. The area of aqua-asymmetric aldol reactions has received much attention recently in light of the perception both of its green chemistry advantages and its analogy to eon-perfected enzyme catalysis. Both chiral metal complexes and small chiral organic molecules have been recently reported to catalyze aldol reactions with relatively high chemical and stereochemical efficiency. This tutorial review describes recent developments in this area.

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Authors+Show Affiliations

Mlynarski J

Institute of Organic Chemistry, Polish Academy of Sciences, Warsaw, Poland. mlynar@icho.edu.pl

Paradowska J

No affiliation info available

MeSH

CarbonCatalysisMetalsOrganic ChemicalsWater

Pub Type(s)

Journal Article

Review

Language

eng

PubMed ID

18648676

Citation

Mlynarski, Jacek, and Joanna Paradowska. "Catalytic Asymmetric Aldol Reactions in Aqueous Media." Chemical Society Reviews, vol. 37, no. 8, 2008, pp. 1502-11.

Mlynarski J, Paradowska J. Catalytic asymmetric aldol reactions in aqueous media. Chem Soc Rev. 2008;37(8):1502-11.

Mlynarski, J., & Paradowska, J. (2008). Catalytic asymmetric aldol reactions in aqueous media. Chemical Society Reviews, 37(8), 1502-11. https://doi.org/10.1039/b710577k

Mlynarski J, Paradowska J. Catalytic Asymmetric Aldol Reactions in Aqueous Media. Chem Soc Rev. 2008;37(8):1502-11. PubMed PMID: 18648676.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - Catalytic asymmetric aldol reactions in aqueous media. AU - Mlynarski,Jacek, AU - Paradowska,Joanna, Y1 - 2008/06/09/ PY - 2008/7/24/pubmed PY - 2008/10/3/medline PY - 2008/7/24/entrez SP - 1502 EP - 11 JF - Chemical Society reviews JO - Chem Soc Rev VL - 37 IS - 8 N2 - Nature has perfected the stereospecific aldol reaction by using aldolase enzymes. While virtually all the biochemical aldol reactions use unmodified donor and acceptor carbonyls and take place under catalytic control in an aqueous environment, the chemical domain of the aldol addition has mostly relied on prior transformation of carbonyl substrates, and the whole process traditionally is carried out in anhydrous solvents. The area of aqua-asymmetric aldol reactions has received much attention recently in light of the perception both of its green chemistry advantages and its analogy to eon-perfected enzyme catalysis. Both chiral metal complexes and small chiral organic molecules have been recently reported to catalyze aldol reactions with relatively high chemical and stereochemical efficiency. This tutorial review describes recent developments in this area. SN - 0306-0012 UR - https://www.unboundmedicine.com/medline/citation/18648676/Catalytic_asymmetric_aldol_reactions_in_aqueous_media_ L2 - https://doi.org/10.1039/b710577k DB - PRIME DP - Unbound Medicine ER -

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Catalytic asymmetric aldol reactions in aqueous media.Chem Soc Rev. 2008 Aug; 37(8):1502-11.CS