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Cardiovascular risk factors in high-need psoriasis patients and its implications for biological therapies.
J Dermatolog Treat 2009; 20(1):42-7JD

Abstract

BACKGROUND

The associations between psoriasis and cardiovascular risk factors are reported to be stronger as psoriasis severity increases. This makes studying cardiovascular risk factors in high-need psoriasis patients, eligible for biological therapy, interesting.

OBJECTIVE

To survey the prevalence of cardiovascular risk factors in high-need psoriasis patients and to compare these data to patients with other dermatological diseases. Furthermore, the implications of these findings for treatment with biologics were outlined.

METHODS

The prevalence of cardiovascular risk factors was investigated in a high-need psoriatic patient cohort and compared to patients with other skin diseases who filled out a questionnaire about the presence of cardiovascular risk factors.

RESULTS

A significantly higher prevalence of obesity, smoking, and hypertension was found for the high-need psoriatic patients' cohort compared with non-psoriatic controls. Striking differences were found with respect to body mass index and obesity, as 35.5% of all high-need psoriatic patients were obese.

CONCLUSIONS

High-need psoriatic patients show a high prevalence of cardiovascular risk factors, and may consequently be predisposed to cardiovascular diseases. As this is relevant for therapy management in daily clinical practice, especially biologics, cardiovascular risk should be evaluated for each high-need psoriasis patient before and during systemic treatment.

Authors+Show Affiliations

Department of Dermatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. R.Driessen@derma.umcn.nlNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

18649164

Citation

Driessen, Rieke J B., et al. "Cardiovascular Risk Factors in High-need Psoriasis Patients and Its Implications for Biological Therapies." The Journal of Dermatological Treatment, vol. 20, no. 1, 2009, pp. 42-7.
Driessen RJ, Boezeman JB, Van De Kerkhof PC, et al. Cardiovascular risk factors in high-need psoriasis patients and its implications for biological therapies. J Dermatolog Treat. 2009;20(1):42-7.
Driessen, R. J., Boezeman, J. B., Van De Kerkhof, P. C., & De Jong, E. M. (2009). Cardiovascular risk factors in high-need psoriasis patients and its implications for biological therapies. The Journal of Dermatological Treatment, 20(1), pp. 42-7. doi:10.1080/09546630802225702.
Driessen RJ, et al. Cardiovascular Risk Factors in High-need Psoriasis Patients and Its Implications for Biological Therapies. J Dermatolog Treat. 2009;20(1):42-7. PubMed PMID: 18649164.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cardiovascular risk factors in high-need psoriasis patients and its implications for biological therapies. AU - Driessen,Rieke J B, AU - Boezeman,Jan B, AU - Van De Kerkhof,Peter C M, AU - De Jong,Elke M G J, PY - 2008/7/24/pubmed PY - 2009/9/2/medline PY - 2008/7/24/entrez SP - 42 EP - 7 JF - The Journal of dermatological treatment JO - J Dermatolog Treat VL - 20 IS - 1 N2 - BACKGROUND: The associations between psoriasis and cardiovascular risk factors are reported to be stronger as psoriasis severity increases. This makes studying cardiovascular risk factors in high-need psoriasis patients, eligible for biological therapy, interesting. OBJECTIVE: To survey the prevalence of cardiovascular risk factors in high-need psoriasis patients and to compare these data to patients with other dermatological diseases. Furthermore, the implications of these findings for treatment with biologics were outlined. METHODS: The prevalence of cardiovascular risk factors was investigated in a high-need psoriatic patient cohort and compared to patients with other skin diseases who filled out a questionnaire about the presence of cardiovascular risk factors. RESULTS: A significantly higher prevalence of obesity, smoking, and hypertension was found for the high-need psoriatic patients' cohort compared with non-psoriatic controls. Striking differences were found with respect to body mass index and obesity, as 35.5% of all high-need psoriatic patients were obese. CONCLUSIONS: High-need psoriatic patients show a high prevalence of cardiovascular risk factors, and may consequently be predisposed to cardiovascular diseases. As this is relevant for therapy management in daily clinical practice, especially biologics, cardiovascular risk should be evaluated for each high-need psoriasis patient before and during systemic treatment. SN - 1471-1753 UR - https://www.unboundmedicine.com/medline/citation/18649164/Cardiovascular_risk_factors_in_high_need_psoriasis_patients_and_its_implications_for_biological_therapies_ L2 - http://www.tandfonline.com/doi/full/10.1080/09546630802225702 DB - PRIME DP - Unbound Medicine ER -