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Helicobacter pylori infection and motor fluctuations in patients with Parkinson's disease.
Mov Disord. 2008 Sep 15; 23(12):1696-700.MD

Abstract

To investigate whether Helicobacter pylori (HP) infection affects the clinical response to levodopa and whether its eradication could improve motor fluctuation in patients with Parkinson's disease (PD). Using the [(13)C] urea breath test, we monitored HP infection in 65 patients with PD and motor fluctuations of the "wearing-off" or delayed "on" types, with or without dyskinesia. We compared the clinical features and response to L-dopa between HP noninfected (n = 30) and HP infected patients (n = 35) by reviewing home diaries kept for 72 hours. Among HP infected patients, we compared the differences in L-dopa "onset" time, "on-time" duration, and scores on the motor examination section of the Unified PD Rating Scale (UPDRS-III) during the medication "on" phase before and after HP eradication. There were no differences in the age, disease duration, Hoehn and Yahr stage, UPDRS-III score, L-dopa daily dose, and frequency of dyskinesia between HP noninfected and HP infected groups. However, L-dopa "onset" time was longer and "on-time" duration was shorter in HP infected patients than in HP noninfected patients (78.4 +/- 28.2 vs. 56.7 +/- 25.1 and 210.0 +/- 75.7 vs. 257.7 +/- 68.9 min, respectively, P < 0.05). HP eradication improved the delay L-dopa "onset" time and short "on-time" duration (to 58.1 +/- 25.6 and to 234.4 +/- 66.5 min, respectively, P < 0.05). These data demonstrated that HP infection could interfere with the absorption of L-dopa and provoke motor fluctuations. HP eradication can improve the motor fluctuations of HP infected patients with PD.

Authors+Show Affiliations

Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. neurolwy@skku.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18649391

Citation

Lee, Won Yong, et al. "Helicobacter Pylori Infection and Motor Fluctuations in Patients With Parkinson's Disease." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 23, no. 12, 2008, pp. 1696-700.
Lee WY, Yoon WT, Shin HY, et al. Helicobacter pylori infection and motor fluctuations in patients with Parkinson's disease. Mov Disord. 2008;23(12):1696-700.
Lee, W. Y., Yoon, W. T., Shin, H. Y., Jeon, S. H., & Rhee, P. L. (2008). Helicobacter pylori infection and motor fluctuations in patients with Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society, 23(12), 1696-700. https://doi.org/10.1002/mds.22190
Lee WY, et al. Helicobacter Pylori Infection and Motor Fluctuations in Patients With Parkinson's Disease. Mov Disord. 2008 Sep 15;23(12):1696-700. PubMed PMID: 18649391.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Helicobacter pylori infection and motor fluctuations in patients with Parkinson's disease. AU - Lee,Won Yong, AU - Yoon,Won Tae, AU - Shin,Hee Young, AU - Jeon,Seong Hee, AU - Rhee,Poong-Lyul, PY - 2008/7/24/pubmed PY - 2009/4/9/medline PY - 2008/7/24/entrez SP - 1696 EP - 700 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov. Disord. VL - 23 IS - 12 N2 - To investigate whether Helicobacter pylori (HP) infection affects the clinical response to levodopa and whether its eradication could improve motor fluctuation in patients with Parkinson's disease (PD). Using the [(13)C] urea breath test, we monitored HP infection in 65 patients with PD and motor fluctuations of the "wearing-off" or delayed "on" types, with or without dyskinesia. We compared the clinical features and response to L-dopa between HP noninfected (n = 30) and HP infected patients (n = 35) by reviewing home diaries kept for 72 hours. Among HP infected patients, we compared the differences in L-dopa "onset" time, "on-time" duration, and scores on the motor examination section of the Unified PD Rating Scale (UPDRS-III) during the medication "on" phase before and after HP eradication. There were no differences in the age, disease duration, Hoehn and Yahr stage, UPDRS-III score, L-dopa daily dose, and frequency of dyskinesia between HP noninfected and HP infected groups. However, L-dopa "onset" time was longer and "on-time" duration was shorter in HP infected patients than in HP noninfected patients (78.4 +/- 28.2 vs. 56.7 +/- 25.1 and 210.0 +/- 75.7 vs. 257.7 +/- 68.9 min, respectively, P < 0.05). HP eradication improved the delay L-dopa "onset" time and short "on-time" duration (to 58.1 +/- 25.6 and to 234.4 +/- 66.5 min, respectively, P < 0.05). These data demonstrated that HP infection could interfere with the absorption of L-dopa and provoke motor fluctuations. HP eradication can improve the motor fluctuations of HP infected patients with PD. SN - 1531-8257 UR - https://www.unboundmedicine.com/medline/citation/18649391/Helicobacter_pylori_infection_and_motor_fluctuations_in_patients_with_Parkinson's_disease_ L2 - https://doi.org/10.1002/mds.22190 DB - PRIME DP - Unbound Medicine ER -