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Determinants of 24-hour urinary oxalate excretion.
Clin J Am Soc Nephrol 2008; 3(5):1453-60CJ

Abstract

BACKGROUND AND OBJECTIVES

Higher levels of urinary oxalate substantially increase the risk of calcium oxalate kidney stones. However, the determinants of urinary oxalate excretion are unclear. The objective was to examine the impact of dietary factors, age, body size, diabetes, and urinary factors on 24-h urinary oxalate.

DESIGN, SETTING, PARTICIPANTS, AND MEASUREMENTS

We conducted a cross-sectional study of 3348 stone forming and non-stone-forming participants in the Health Professionals Follow-up Study (men), the Nurses' Health Study (older women), and the Nurses' Health Study II (younger women).

RESULTS

Median urinary oxalate was 39 mg/d in men, 27 mg/d in older women, and 26 mg/d in younger women. Participants in the highest quartile of dietary oxalate excreted 1.7 mg/d more urinary oxalate than participants in the lowest quartile (P trend 0.001). The relation between dietary and urinary oxalate was similar in individuals with and without nephrolithiasis. Participants consuming 1000 mg/d or more of vitamin C excreted 6.8 mg/d more urinary oxalate than participants consuming <90 mg/d (P trend < 0.001). Body mass index, total fructose intake, and 24-h urinary potassium, magnesium, and phosphorus levels also were positively associated with urinary oxalate. Calcium intake and age were inversely associated with urinary oxalate. After adjustment for body size, participants with diabetes excreted 2.0 mg/d more urinary oxalate than those without diabetes (P < 0.01).

CONCLUSIONS

The impact of dietary oxalate on urinary oxalate appears to be small. Further investigation of factors influencing urinary oxalate may lead to new approaches to prevent calcium kidney stones.

Authors+Show Affiliations

Renal Division and Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. entaylor@partners.orgNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

18650406

Citation

Taylor, Eric N., and Gary C. Curhan. "Determinants of 24-hour Urinary Oxalate Excretion." Clinical Journal of the American Society of Nephrology : CJASN, vol. 3, no. 5, 2008, pp. 1453-60.
Taylor EN, Curhan GC. Determinants of 24-hour urinary oxalate excretion. Clin J Am Soc Nephrol. 2008;3(5):1453-60.
Taylor, E. N., & Curhan, G. C. (2008). Determinants of 24-hour urinary oxalate excretion. Clinical Journal of the American Society of Nephrology : CJASN, 3(5), pp. 1453-60. doi:10.2215/CJN.01410308.
Taylor EN, Curhan GC. Determinants of 24-hour Urinary Oxalate Excretion. Clin J Am Soc Nephrol. 2008;3(5):1453-60. PubMed PMID: 18650406.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Determinants of 24-hour urinary oxalate excretion. AU - Taylor,Eric N, AU - Curhan,Gary C, Y1 - 2008/07/23/ PY - 2008/7/25/pubmed PY - 2008/11/19/medline PY - 2008/7/25/entrez SP - 1453 EP - 60 JF - Clinical journal of the American Society of Nephrology : CJASN JO - Clin J Am Soc Nephrol VL - 3 IS - 5 N2 - BACKGROUND AND OBJECTIVES: Higher levels of urinary oxalate substantially increase the risk of calcium oxalate kidney stones. However, the determinants of urinary oxalate excretion are unclear. The objective was to examine the impact of dietary factors, age, body size, diabetes, and urinary factors on 24-h urinary oxalate. DESIGN, SETTING, PARTICIPANTS, AND MEASUREMENTS: We conducted a cross-sectional study of 3348 stone forming and non-stone-forming participants in the Health Professionals Follow-up Study (men), the Nurses' Health Study (older women), and the Nurses' Health Study II (younger women). RESULTS: Median urinary oxalate was 39 mg/d in men, 27 mg/d in older women, and 26 mg/d in younger women. Participants in the highest quartile of dietary oxalate excreted 1.7 mg/d more urinary oxalate than participants in the lowest quartile (P trend 0.001). The relation between dietary and urinary oxalate was similar in individuals with and without nephrolithiasis. Participants consuming 1000 mg/d or more of vitamin C excreted 6.8 mg/d more urinary oxalate than participants consuming <90 mg/d (P trend < 0.001). Body mass index, total fructose intake, and 24-h urinary potassium, magnesium, and phosphorus levels also were positively associated with urinary oxalate. Calcium intake and age were inversely associated with urinary oxalate. After adjustment for body size, participants with diabetes excreted 2.0 mg/d more urinary oxalate than those without diabetes (P < 0.01). CONCLUSIONS: The impact of dietary oxalate on urinary oxalate appears to be small. Further investigation of factors influencing urinary oxalate may lead to new approaches to prevent calcium kidney stones. SN - 1555-905X UR - https://www.unboundmedicine.com/medline/citation/18650406/Determinants_of_24_hour_urinary_oxalate_excretion_ L2 - http://cjasn.asnjournals.org/cgi/pmidlookup?view=long&amp;pmid=18650406 DB - PRIME DP - Unbound Medicine ER -