Citation
Isoda, Norikazu, et al. "Potency of an Inactivated Avian Influenza Vaccine Prepared From a Non-pathogenic H5N1 Reassortant Virus Generated Between Isolates From Migratory Ducks in Asia." Archives of Virology, vol. 153, no. 9, 2008, pp. 1685-92.
Isoda N, Sakoda Y, Kishida N, et al. Potency of an inactivated avian influenza vaccine prepared from a non-pathogenic H5N1 reassortant virus generated between isolates from migratory ducks in Asia. Arch Virol. 2008;153(9):1685-92.
Isoda, N., Sakoda, Y., Kishida, N., Soda, K., Sakabe, S., Sakamoto, R., Imamura, T., Sakaguchi, M., Sasaki, T., Kokumai, N., Ohgitani, T., Saijo, K., Sawata, A., Hagiwara, J., Lin, Z., & Kida, H. (2008). Potency of an inactivated avian influenza vaccine prepared from a non-pathogenic H5N1 reassortant virus generated between isolates from migratory ducks in Asia. Archives of Virology, 153(9), 1685-92. https://doi.org/10.1007/s00705-008-0171-1
Isoda N, et al. Potency of an Inactivated Avian Influenza Vaccine Prepared From a Non-pathogenic H5N1 Reassortant Virus Generated Between Isolates From Migratory Ducks in Asia. Arch Virol. 2008;153(9):1685-92. PubMed PMID: 18651092.
TY - JOUR
T1 - Potency of an inactivated avian influenza vaccine prepared from a non-pathogenic H5N1 reassortant virus generated between isolates from migratory ducks in Asia.
AU - Isoda,Norikazu,
AU - Sakoda,Yoshihiro,
AU - Kishida,Noriko,
AU - Soda,Kosuke,
AU - Sakabe,Saori,
AU - Sakamoto,Ryuichi,
AU - Imamura,Takashi,
AU - Sakaguchi,Masashi,
AU - Sasaki,Takashi,
AU - Kokumai,Norihide,
AU - Ohgitani,Toshiaki,
AU - Saijo,Kazue,
AU - Sawata,Akira,
AU - Hagiwara,Junko,
AU - Lin,Zhifeng,
AU - Kida,Hiroshi,
Y1 - 2008/07/25/
PY - 2008/02/29/received
PY - 2008/06/20/accepted
PY - 2008/7/25/pubmed
PY - 2008/11/1/medline
PY - 2008/7/25/entrez
SP - 1685
EP - 92
JF - Archives of virology
JO - Arch Virol
VL - 153
IS - 9
N2 - A reassortant influenza virus, A/duck/Hokkaido/Vac-1/2004 (H5N1) (Dk/Vac-1/04), was generated between non-pathogenic avian influenza viruses isolated from migratory ducks in Asia. Dk/Vac-1/04 (H5N1) virus particles propagated in embryonated chicken eggs were inactivated with formalin and adjuvanted with mineral oil to form a water-in-oil emulsion. The resulting vaccine was injected intramuscularly into chickens. The chickens were challenged with either of the highly pathogenic avian influenza virus strains A/chicken/Yamaguchi/7/2004 (H5N1) or A/swan/Mongolia/3/2005 (H5N1) at 21 days post-vaccination (p. v.), when the geometric mean serum HI titers of the birds was 64 with the challenge virus strains. The vaccinated chickens were protected from manifestation of disease signs upon challenge with either of the highly pathogenic avian influenza viruses. However, challenge virus was recovered at low titers from the birds at 2 and 4 days post-challenge (p.c.). All 3 chickens challenged at 6 days p.v. died, whereas 3 chickens challenged at 8 days p.v. survived. These results indicate that the present vaccine confers clinical protection and reduction of virus shedding against highly pathogenic avian influenza virus challenge and should be useful as an optional tool in emergency cases.
SN - 0304-8608
UR - https://www.unboundmedicine.com/medline/citation/18651092/Potency_of_an_inactivated_avian_influenza_vaccine_prepared_from_a_non_pathogenic_H5N1_reassortant_virus_generated_between_isolates_from_migratory_ducks_in_Asia_
L2 - https://dx.doi.org/10.1007/s00705-008-0171-1
DB - PRIME
DP - Unbound Medicine
ER -