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Dissociating space and trace in dorsal and ventral hippocampus.
Hippocampus. 2009 Jan; 19(1):20-32.H

Abstract

Emerging evidence suggests that the hippocampus can be anatomically and functionally dissociated along its septotemporal axis into dorsal and ventral subregions. With respect to function, we have recently demonstrated that pre-training excitotoxic lesions of ventral, but not dorsal, hippocampus impair the acquisition of trace fear conditioning, whereas post-training lesions of either dorsal or ventral hippocampus impair the subsequent expression of trace fear conditioning (Yoon and Otto (2007) Neurobiol Learn Mem 87:464-475). In addition to trace fear conditioning, dorsal and ventral hippocampus appear to be differentially involved in a number of spatial memory tasks. The present study examined the effects of temporary inactivation of dorsal or ventral hippocampus on the acquisition and expression of trace fear conditioning and on performance of a spatial delayed reinforced alternation task. The findings demonstrate a double dissociation of dorsal and ventral hippocampal function: inactivation of ventral, but not dorsal, hippocampus attenuated the acquisition and expression of trace fear conditioning, whereas inactivation of dorsal, but not ventral, hippocampus dramatically impaired performance in the delayed reinforced alternation task. These data further support the notion that dorsal and ventral hippocampus contribute differentially to performance in a variety of paradigms.

Authors+Show Affiliations

Department of Psychology, Rutgers University, New Brunswick, New Jersey, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

18651617

Citation

Czerniawski, Jennifer, et al. "Dissociating Space and Trace in Dorsal and Ventral Hippocampus." Hippocampus, vol. 19, no. 1, 2009, pp. 20-32.
Czerniawski J, Yoon T, Otto T. Dissociating space and trace in dorsal and ventral hippocampus. Hippocampus. 2009;19(1):20-32.
Czerniawski, J., Yoon, T., & Otto, T. (2009). Dissociating space and trace in dorsal and ventral hippocampus. Hippocampus, 19(1), 20-32. https://doi.org/10.1002/hipo.20469
Czerniawski J, Yoon T, Otto T. Dissociating Space and Trace in Dorsal and Ventral Hippocampus. Hippocampus. 2009;19(1):20-32. PubMed PMID: 18651617.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dissociating space and trace in dorsal and ventral hippocampus. AU - Czerniawski,Jennifer, AU - Yoon,Taejib, AU - Otto,Tim, PY - 2008/7/25/pubmed PY - 2009/2/28/medline PY - 2008/7/25/entrez SP - 20 EP - 32 JF - Hippocampus JO - Hippocampus VL - 19 IS - 1 N2 - Emerging evidence suggests that the hippocampus can be anatomically and functionally dissociated along its septotemporal axis into dorsal and ventral subregions. With respect to function, we have recently demonstrated that pre-training excitotoxic lesions of ventral, but not dorsal, hippocampus impair the acquisition of trace fear conditioning, whereas post-training lesions of either dorsal or ventral hippocampus impair the subsequent expression of trace fear conditioning (Yoon and Otto (2007) Neurobiol Learn Mem 87:464-475). In addition to trace fear conditioning, dorsal and ventral hippocampus appear to be differentially involved in a number of spatial memory tasks. The present study examined the effects of temporary inactivation of dorsal or ventral hippocampus on the acquisition and expression of trace fear conditioning and on performance of a spatial delayed reinforced alternation task. The findings demonstrate a double dissociation of dorsal and ventral hippocampal function: inactivation of ventral, but not dorsal, hippocampus attenuated the acquisition and expression of trace fear conditioning, whereas inactivation of dorsal, but not ventral, hippocampus dramatically impaired performance in the delayed reinforced alternation task. These data further support the notion that dorsal and ventral hippocampus contribute differentially to performance in a variety of paradigms. SN - 1098-1063 UR - https://www.unboundmedicine.com/medline/citation/18651617/Dissociating_space_and_trace_in_dorsal_and_ventral_hippocampus_ L2 - https://doi.org/10.1002/hipo.20469 DB - PRIME DP - Unbound Medicine ER -