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A case of transfusion-transmitted hepatitis E caused by blood from a donor infected with hepatitis E virus via zoonotic food-borne route.
Transfusion. 2008 Jul; 48(7):1368-75.T

Abstract

BACKGROUND

Five cases of transfusion transmission of hepatitis E virus (HEV) have been reported so far. The infection routes of the causative donors remain unclear, however. Also, the progress of virus markers in the entire course of HEV infection has not been well documented.

STUDY DESIGN AND METHODS

Nucleic acid testing was performed by real-time reverse transcription-polymerase chain reaction targeting the open reading frame 2 region of HEV. Full-length nucleotide sequences of HEV RNA were detected by direct sequencing.

RESULTS

Lookback study of a HEV-positive donor revealed that the platelets (PLTs) donated from him 2 weeks previously contained HEV RNA and were transfused to a patient. Thirteen relatives including the donor were ascertained to enjoy grilled pork meats together in a barbecue restaurant 23 days before the donation. Thereafter, his father died of fulminant hepatitis E and the other 6 members showed serum markers of HEV infection. In the recipient, HEV was detected in serum on Day 22 and reached the peak of 7.2 log copies per mL on Day 44 followed by the steep increase of alanine aminotransferase. Immunoglobulin G anti-HEV emerged on Day 67; subsequently, hepatitis was resolved. HEV RNA sequences from the donor and recipient were an identical, Japan-indigenous strain of genotype 4. HEV RNA was detectable up to Day 97 in serum, Day 85 in feces, and Day 71 in saliva.

CONCLUSION

A transfusion-transmitted hepatitis E case by blood from a donor infected via the zoonotic food-borne route and the progress of HEV markers in the entire course are demonstrated. Further studies are needed to clarify the epidemiology and the transfusion-related risks for HEV even in industrialized countries.

Authors+Show Affiliations

Hokkaido Red Cross Blood Center, Sapporo, Japan. kmatsu@hokkaido.bc.jrc.or.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18651907

Citation

Matsubayashi, Keiji, et al. "A Case of Transfusion-transmitted Hepatitis E Caused By Blood From a Donor Infected With Hepatitis E Virus Via Zoonotic Food-borne Route." Transfusion, vol. 48, no. 7, 2008, pp. 1368-75.
Matsubayashi K, Kang JH, Sakata H, et al. A case of transfusion-transmitted hepatitis E caused by blood from a donor infected with hepatitis E virus via zoonotic food-borne route. Transfusion. 2008;48(7):1368-75.
Matsubayashi, K., Kang, J. H., Sakata, H., Takahashi, K., Shindo, M., Kato, M., Sato, S., Kato, T., Nishimori, H., Tsuji, K., Maguchi, H., Yoshida, J., Maekubo, H., Mishiro, S., & Ikeda, H. (2008). A case of transfusion-transmitted hepatitis E caused by blood from a donor infected with hepatitis E virus via zoonotic food-borne route. Transfusion, 48(7), 1368-75. https://doi.org/10.1111/j.1537-2995.2008.01722.x
Matsubayashi K, et al. A Case of Transfusion-transmitted Hepatitis E Caused By Blood From a Donor Infected With Hepatitis E Virus Via Zoonotic Food-borne Route. Transfusion. 2008;48(7):1368-75. PubMed PMID: 18651907.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A case of transfusion-transmitted hepatitis E caused by blood from a donor infected with hepatitis E virus via zoonotic food-borne route. AU - Matsubayashi,Keiji, AU - Kang,Jong-Hon, AU - Sakata,Hidekatsu, AU - Takahashi,Kazuaki, AU - Shindo,Motohiro, AU - Kato,Masaru, AU - Sato,Shinichiro, AU - Kato,Toshiaki, AU - Nishimori,Hiroyuki, AU - Tsuji,Kunihiko, AU - Maguchi,Hiroyuki, AU - Yoshida,Jun-Ichi, AU - Maekubo,Hiroshi, AU - Mishiro,Shunji, AU - Ikeda,Hisami, PY - 2008/7/25/pubmed PY - 2008/9/23/medline PY - 2008/7/25/entrez SP - 1368 EP - 75 JF - Transfusion JO - Transfusion VL - 48 IS - 7 N2 - BACKGROUND: Five cases of transfusion transmission of hepatitis E virus (HEV) have been reported so far. The infection routes of the causative donors remain unclear, however. Also, the progress of virus markers in the entire course of HEV infection has not been well documented. STUDY DESIGN AND METHODS: Nucleic acid testing was performed by real-time reverse transcription-polymerase chain reaction targeting the open reading frame 2 region of HEV. Full-length nucleotide sequences of HEV RNA were detected by direct sequencing. RESULTS: Lookback study of a HEV-positive donor revealed that the platelets (PLTs) donated from him 2 weeks previously contained HEV RNA and were transfused to a patient. Thirteen relatives including the donor were ascertained to enjoy grilled pork meats together in a barbecue restaurant 23 days before the donation. Thereafter, his father died of fulminant hepatitis E and the other 6 members showed serum markers of HEV infection. In the recipient, HEV was detected in serum on Day 22 and reached the peak of 7.2 log copies per mL on Day 44 followed by the steep increase of alanine aminotransferase. Immunoglobulin G anti-HEV emerged on Day 67; subsequently, hepatitis was resolved. HEV RNA sequences from the donor and recipient were an identical, Japan-indigenous strain of genotype 4. HEV RNA was detectable up to Day 97 in serum, Day 85 in feces, and Day 71 in saliva. CONCLUSION: A transfusion-transmitted hepatitis E case by blood from a donor infected via the zoonotic food-borne route and the progress of HEV markers in the entire course are demonstrated. Further studies are needed to clarify the epidemiology and the transfusion-related risks for HEV even in industrialized countries. SN - 0041-1132 UR - https://www.unboundmedicine.com/medline/citation/18651907/A_case_of_transfusion_transmitted_hepatitis_E_caused_by_blood_from_a_donor_infected_with_hepatitis_E_virus_via_zoonotic_food_borne_route_ L2 - https://doi.org/10.1111/j.1537-2995.2008.01722.x DB - PRIME DP - Unbound Medicine ER -