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Anatomy, pigmentation, ventral and dorsal subpopulations of the substantia nigra, and differential cell death in Parkinson's disease.
J Neurol Neurosurg Psychiatry. 1991 May; 54(5):388-96.JN

Abstract

In six control subjects pars compacta nerve cells in the ventrolateral substantia nigra had a lower melanin content than nerve cells in the dorsomedial region. This coincides with a natural anatomical division into ventral and dorsal tiers, which represent functionally distinct populations. In six cases of Parkinson's disease (PD) the ventral tier showed very few surviving nerve cells compared with preservation of cells in the dorsal tier. In 13 subjects without PD, but with nigral Lewy bodies and cell loss, the degenerative process started in the ventral tier, and spread to the dorsal tier. This pattern of selective degeneration of nigrostriatal neurons is not seen in ageing or after acute administration of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine).

Authors+Show Affiliations

King's College School of Medicine and Dentistry, London.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1865199

Citation

Gibb, W R., and A J. Lees. "Anatomy, Pigmentation, Ventral and Dorsal Subpopulations of the Substantia Nigra, and Differential Cell Death in Parkinson's Disease." Journal of Neurology, Neurosurgery, and Psychiatry, vol. 54, no. 5, 1991, pp. 388-96.
Gibb WR, Lees AJ. Anatomy, pigmentation, ventral and dorsal subpopulations of the substantia nigra, and differential cell death in Parkinson's disease. J Neurol Neurosurg Psychiatry. 1991;54(5):388-96.
Gibb, W. R., & Lees, A. J. (1991). Anatomy, pigmentation, ventral and dorsal subpopulations of the substantia nigra, and differential cell death in Parkinson's disease. Journal of Neurology, Neurosurgery, and Psychiatry, 54(5), 388-96.
Gibb WR, Lees AJ. Anatomy, Pigmentation, Ventral and Dorsal Subpopulations of the Substantia Nigra, and Differential Cell Death in Parkinson's Disease. J Neurol Neurosurg Psychiatry. 1991;54(5):388-96. PubMed PMID: 1865199.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anatomy, pigmentation, ventral and dorsal subpopulations of the substantia nigra, and differential cell death in Parkinson's disease. AU - Gibb,W R, AU - Lees,A J, PY - 1991/5/1/pubmed PY - 1991/5/1/medline PY - 1991/5/1/entrez SP - 388 EP - 96 JF - Journal of neurology, neurosurgery, and psychiatry JO - J Neurol Neurosurg Psychiatry VL - 54 IS - 5 N2 - In six control subjects pars compacta nerve cells in the ventrolateral substantia nigra had a lower melanin content than nerve cells in the dorsomedial region. This coincides with a natural anatomical division into ventral and dorsal tiers, which represent functionally distinct populations. In six cases of Parkinson's disease (PD) the ventral tier showed very few surviving nerve cells compared with preservation of cells in the dorsal tier. In 13 subjects without PD, but with nigral Lewy bodies and cell loss, the degenerative process started in the ventral tier, and spread to the dorsal tier. This pattern of selective degeneration of nigrostriatal neurons is not seen in ageing or after acute administration of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine). SN - 0022-3050 UR - https://www.unboundmedicine.com/medline/citation/1865199/Anatomy_pigmentation_ventral_and_dorsal_subpopulations_of_the_substantia_nigra_and_differential_cell_death_in_Parkinson's_disease_ L2 - https://jnnp.bmj.com/lookup/pmidlookup?view=long&pmid=1865199 DB - PRIME DP - Unbound Medicine ER -