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Formulation variables influencing drug release from layered matrix system comprising chitosan and xanthan gum.
AAPS PharmSciTech. 2008; 9(3):870-7.AP

Abstract

The purpose of this study was to investigate the formulation variables influencing the drug release from the layered tablets containing chitosan and xanthan gum as matrix component. Increasing the amount of lactose could diminish pH sensitive release behavior of these matrix tablets. Effect of formulation variables on drug release from the prepared three-layered matrix tablets was investigated. The amount of drug loading did not affect the drug release which was influenced by the hydrodynamic force and the matrix composition. An increase in stirring rate correspondingly increased the release rate. Moreover, incorporation of soluble diluents in core or barrier could enhance the drug release. Least square fitting the experimental dissolution data to the mathematical expressions (power law, first order, Higuchi's and zero order) was carried out to study the drug release mechanism. Most dissolution profiles of the prepared three-layered tablets provided a better fit to zero order kinetic than to first order kinetic and Higuchi's equation.

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Authors+Show Affiliations

Phaechamud T
Department of Pharmaceutical Technology, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom, 73000, Thailand. thawatchaienator@gmail.com
Ritthidej GC
No affiliation info available

MeSH

Chemistry, PharmaceuticalChitosanDelayed-Action PreparationsHydrogen-Ion ConcentrationPolysaccharides, BacterialSolubilityTablets

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18654863

Citation

Phaechamud, Thawatchai, and Garnpimol C. Ritthidej. "Formulation Variables Influencing Drug Release From Layered Matrix System Comprising Chitosan and Xanthan Gum." AAPS PharmSciTech, vol. 9, no. 3, 2008, pp. 870-7.
Phaechamud T, Ritthidej GC. Formulation variables influencing drug release from layered matrix system comprising chitosan and xanthan gum. AAPS PharmSciTech. 2008;9(3):870-7.
Phaechamud, T., & Ritthidej, G. C. (2008). Formulation variables influencing drug release from layered matrix system comprising chitosan and xanthan gum. AAPS PharmSciTech, 9(3), 870-7. https://doi.org/10.1208/s12249-008-9127-8
Phaechamud T, Ritthidej GC. Formulation Variables Influencing Drug Release From Layered Matrix System Comprising Chitosan and Xanthan Gum. AAPS PharmSciTech. 2008;9(3):870-7. PubMed PMID: 18654863.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Formulation variables influencing drug release from layered matrix system comprising chitosan and xanthan gum. AU - Phaechamud,Thawatchai, AU - Ritthidej,Garnpimol C, Y1 - 2008/07/25/ PY - 2008/02/25/received PY - 2008/06/16/accepted PY - 2008/7/26/pubmed PY - 2009/5/14/medline PY - 2008/7/26/entrez SP - 870 EP - 7 JF - AAPS PharmSciTech JO - AAPS PharmSciTech VL - 9 IS - 3 N2 - The purpose of this study was to investigate the formulation variables influencing the drug release from the layered tablets containing chitosan and xanthan gum as matrix component. Increasing the amount of lactose could diminish pH sensitive release behavior of these matrix tablets. Effect of formulation variables on drug release from the prepared three-layered matrix tablets was investigated. The amount of drug loading did not affect the drug release which was influenced by the hydrodynamic force and the matrix composition. An increase in stirring rate correspondingly increased the release rate. Moreover, incorporation of soluble diluents in core or barrier could enhance the drug release. Least square fitting the experimental dissolution data to the mathematical expressions (power law, first order, Higuchi's and zero order) was carried out to study the drug release mechanism. Most dissolution profiles of the prepared three-layered tablets provided a better fit to zero order kinetic than to first order kinetic and Higuchi's equation. SN - 1530-9932 UR - https://www.unboundmedicine.com/medline/citation/18654863/Formulation_variables_influencing_drug_release_from_layered_matrix_system_comprising_chitosan_and_xanthan_gum_ L2 - https://dx.doi.org/10.1208/s12249-008-9127-8 DB - PRIME DP - Unbound Medicine ER -