Tags

Type your tag names separated by a space and hit enter

Malondialdehyde, carbonyl proteins and albumin-disulphide as useful oxidative markers in mild cognitive impairment and Alzheimer's disease.
Free Radic Res 2008; 42(7):633-8FR

Abstract

The question arises as to whether oxidative stress has a primary role in neurodegeneration or is a secondary end-stage epiphenomenon. The aim of the present study was to determine oxidative stress parameters like malondialdehyde (MDA), carbonyl proteins (CP) and Albumin-disulphide (Alb-SSR) and relate these parameters to the immune parameter neopterin, folic acid and vitamin B12 as vitamins and homocysteine in patients with neuro-degenerative diseases (NDD), namely mild cognitive impairment (MCI) and Alzheimer's disease (AD) compared to an aged matched control group. MDA, CP and Alb-SSR were significantly increased in the NDD group compared to controls, but not vitamin B12, folic acid and neopterin. Significant correlations were found between CP and Alb-SSR, CP and MDA and between MDA and Alb-SSR including patients with NDD and the control group. These results support the hypothesis that oxidative damage to lipids and proteins is an important early event in the pathogenesis of neurodegenerative diseases.

Authors+Show Affiliations

Institute of Physiological Chemistry, Center for Physiological Medicine, Medical University of Graz,8010 Graz, Austria. joachim.greilberger@meduni-graz.atNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18654878

Citation

Greilberger, J, et al. "Malondialdehyde, Carbonyl Proteins and Albumin-disulphide as Useful Oxidative Markers in Mild Cognitive Impairment and Alzheimer's Disease." Free Radical Research, vol. 42, no. 7, 2008, pp. 633-8.
Greilberger J, Koidl C, Greilberger M, et al. Malondialdehyde, carbonyl proteins and albumin-disulphide as useful oxidative markers in mild cognitive impairment and Alzheimer's disease. Free Radic Res. 2008;42(7):633-8.
Greilberger, J., Koidl, C., Greilberger, M., Lamprecht, M., Schroecksnadel, K., Leblhuber, F., ... Oettl, K. (2008). Malondialdehyde, carbonyl proteins and albumin-disulphide as useful oxidative markers in mild cognitive impairment and Alzheimer's disease. Free Radical Research, 42(7), pp. 633-8. doi:10.1080/10715760802255764.
Greilberger J, et al. Malondialdehyde, Carbonyl Proteins and Albumin-disulphide as Useful Oxidative Markers in Mild Cognitive Impairment and Alzheimer's Disease. Free Radic Res. 2008;42(7):633-8. PubMed PMID: 18654878.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Malondialdehyde, carbonyl proteins and albumin-disulphide as useful oxidative markers in mild cognitive impairment and Alzheimer's disease. AU - Greilberger,J, AU - Koidl,C, AU - Greilberger,M, AU - Lamprecht,M, AU - Schroecksnadel,K, AU - Leblhuber,F, AU - Fuchs,D, AU - Oettl,K, PY - 2008/7/26/pubmed PY - 2008/9/19/medline PY - 2008/7/26/entrez SP - 633 EP - 8 JF - Free radical research JO - Free Radic. Res. VL - 42 IS - 7 N2 - The question arises as to whether oxidative stress has a primary role in neurodegeneration or is a secondary end-stage epiphenomenon. The aim of the present study was to determine oxidative stress parameters like malondialdehyde (MDA), carbonyl proteins (CP) and Albumin-disulphide (Alb-SSR) and relate these parameters to the immune parameter neopterin, folic acid and vitamin B12 as vitamins and homocysteine in patients with neuro-degenerative diseases (NDD), namely mild cognitive impairment (MCI) and Alzheimer's disease (AD) compared to an aged matched control group. MDA, CP and Alb-SSR were significantly increased in the NDD group compared to controls, but not vitamin B12, folic acid and neopterin. Significant correlations were found between CP and Alb-SSR, CP and MDA and between MDA and Alb-SSR including patients with NDD and the control group. These results support the hypothesis that oxidative damage to lipids and proteins is an important early event in the pathogenesis of neurodegenerative diseases. SN - 1029-2470 UR - https://www.unboundmedicine.com/medline/citation/18654878/Malondialdehyde_carbonyl_proteins_and_albumin_disulphide_as_useful_oxidative_markers_in_mild_cognitive_impairment_and_Alzheimer's_disease_ L2 - http://www.tandfonline.com/doi/full/10.1080/10715760802255764 DB - PRIME DP - Unbound Medicine ER -