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Zinc deficiency induces depression-like symptoms in adult rats.
Physiol Behav. 2008 Oct 20; 95(3):365-9.PB

Abstract

There is mounting evidence suggesting a link between serum zinc levels and clinical depression. Not only is serum zinc negatively correlated with the severity of symptoms, but zinc levels appear to be lowest in patients who do not respond to antidepressant drug therapy. It is not known if reduced zinc levels are contributing to depression, or the result of dietary or other factors associated with major depression. Thus, we designed this study to test the hypothesis that dietary zinc deficiency would induce depression-like behaviors in rats. Two-month-old male rats were fed zinc adequate (ZA, 30 ppm), deficient (ZD, 1 ppm), or supplemented (ZS, 180 ppm) diets for 3 weeks. Consistent with the development of depression, ZD rats displayed anorexia (p<0.001), anhedonia (reduced saccharin:water intake, p< 0.001), and increased anxiety-like behaviors in a light-dark box test (p<0.05). Furthermore, the antidepressant drug fluoxetine (10 mg/kg body wt) reduced behavioral despair, as measured by the forced swim test, in rats fed the ZA and ZS rats (p<0.05), but was ineffective in ZD rats. Together these studies suggest that zinc deficiency leads to the development of depression-like behaviors that may be refractory to antidepressant treatment.

Authors+Show Affiliations

Department of Nutrition, Food & Exercise Sciences, Florida State University, Tallahassee, Florida 32306-4340, United States.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18655800

Citation

Tassabehji, Nadine M., et al. "Zinc Deficiency Induces Depression-like Symptoms in Adult Rats." Physiology & Behavior, vol. 95, no. 3, 2008, pp. 365-9.
Tassabehji NM, Corniola RS, Alshingiti A, et al. Zinc deficiency induces depression-like symptoms in adult rats. Physiol Behav. 2008;95(3):365-9.
Tassabehji, N. M., Corniola, R. S., Alshingiti, A., & Levenson, C. W. (2008). Zinc deficiency induces depression-like symptoms in adult rats. Physiology & Behavior, 95(3), 365-9. https://doi.org/10.1016/j.physbeh.2008.06.017
Tassabehji NM, et al. Zinc Deficiency Induces Depression-like Symptoms in Adult Rats. Physiol Behav. 2008 Oct 20;95(3):365-9. PubMed PMID: 18655800.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Zinc deficiency induces depression-like symptoms in adult rats. AU - Tassabehji,Nadine M, AU - Corniola,Rikki S, AU - Alshingiti,Almamoun, AU - Levenson,Cathy W, Y1 - 2008/07/03/ PY - 2007/11/15/received PY - 2008/05/29/revised PY - 2008/06/27/accepted PY - 2008/7/29/pubmed PY - 2009/2/4/medline PY - 2008/7/29/entrez SP - 365 EP - 9 JF - Physiology & behavior JO - Physiol Behav VL - 95 IS - 3 N2 - There is mounting evidence suggesting a link between serum zinc levels and clinical depression. Not only is serum zinc negatively correlated with the severity of symptoms, but zinc levels appear to be lowest in patients who do not respond to antidepressant drug therapy. It is not known if reduced zinc levels are contributing to depression, or the result of dietary or other factors associated with major depression. Thus, we designed this study to test the hypothesis that dietary zinc deficiency would induce depression-like behaviors in rats. Two-month-old male rats were fed zinc adequate (ZA, 30 ppm), deficient (ZD, 1 ppm), or supplemented (ZS, 180 ppm) diets for 3 weeks. Consistent with the development of depression, ZD rats displayed anorexia (p<0.001), anhedonia (reduced saccharin:water intake, p< 0.001), and increased anxiety-like behaviors in a light-dark box test (p<0.05). Furthermore, the antidepressant drug fluoxetine (10 mg/kg body wt) reduced behavioral despair, as measured by the forced swim test, in rats fed the ZA and ZS rats (p<0.05), but was ineffective in ZD rats. Together these studies suggest that zinc deficiency leads to the development of depression-like behaviors that may be refractory to antidepressant treatment. SN - 0031-9384 UR - https://www.unboundmedicine.com/medline/citation/18655800/Zinc_deficiency_induces_depression_like_symptoms_in_adult_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0031-9384(08)00209-6 DB - PRIME DP - Unbound Medicine ER -