Tags

Type your tag names separated by a space and hit enter

Antidepressant-like effect of liquiritin from Glycyrrhiza uralensis in chronic variable stress induced depression model rats.
Behav Brain Res. 2008 Dec 01; 194(1):108-13.BB

Abstract

Many flavonoids extracted from nature plants have been reported to exert antidepressant-like effect in animal studies. The present study was designed to observe the effects of liquiritin, a flavone compound derived from Glycyrrhiza uralensis, on the behaviors of chronic variable stress induced depression model rats and to explore the possible association between its antidepressant-like effect and antioxidative activity by measuring erythrocyte superoxide dismutase (SOD) activity and plasma malondialdehyde (MDA) level of the experimental animals. With the exposure to stressor once daily for consecutive 5 weeks, liquiritin and a positive control drug fluoxetine were administered via gastric intubation to rats once daily for consecutive 3 weeks from the 3rd week. The results showed that CVS reduced open-field activity and sucrose consumption significantly, but increased immobility time in forced swimming test. Treatment of liquiritin could effectively reverse alteration in immobility time and sucrose consumption but did not show significant effect on open-field activity. Moreover, liquiritin could increase SOD activity, inhibit lipid peroxidation, and lessen production of MDA, while fluoxetine did not. In conclusion, the present study demonstrated a potential antidepressant-like effect of liquiritin treatment on chronic variable stress induced depression model rats, which might be related to defense of liquiritin against oxidative stress.

Authors+Show Affiliations

Key Laboratory for Mental Health, Ministry of Health, Institute of Mental Health, Peking University, 51 Huayuan Bei Road, Haidian District, Beijing 100083, PR China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18655806

Citation

Zhao, Zhiyu, et al. "Antidepressant-like Effect of Liquiritin From Glycyrrhiza Uralensis in Chronic Variable Stress Induced Depression Model Rats." Behavioural Brain Research, vol. 194, no. 1, 2008, pp. 108-13.
Zhao Z, Wang W, Guo H, et al. Antidepressant-like effect of liquiritin from Glycyrrhiza uralensis in chronic variable stress induced depression model rats. Behav Brain Res. 2008;194(1):108-13.
Zhao, Z., Wang, W., Guo, H., & Zhou, D. (2008). Antidepressant-like effect of liquiritin from Glycyrrhiza uralensis in chronic variable stress induced depression model rats. Behavioural Brain Research, 194(1), 108-13. https://doi.org/10.1016/j.bbr.2008.06.030
Zhao Z, et al. Antidepressant-like Effect of Liquiritin From Glycyrrhiza Uralensis in Chronic Variable Stress Induced Depression Model Rats. Behav Brain Res. 2008 Dec 1;194(1):108-13. PubMed PMID: 18655806.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antidepressant-like effect of liquiritin from Glycyrrhiza uralensis in chronic variable stress induced depression model rats. AU - Zhao,Zhiyu, AU - Wang,Weixing, AU - Guo,Hongzhu, AU - Zhou,Dongfeng, Y1 - 2008/07/04/ PY - 2008/04/25/received PY - 2008/06/23/revised PY - 2008/06/26/accepted PY - 2008/7/29/pubmed PY - 2009/1/16/medline PY - 2008/7/29/entrez SP - 108 EP - 13 JF - Behavioural brain research JO - Behav Brain Res VL - 194 IS - 1 N2 - Many flavonoids extracted from nature plants have been reported to exert antidepressant-like effect in animal studies. The present study was designed to observe the effects of liquiritin, a flavone compound derived from Glycyrrhiza uralensis, on the behaviors of chronic variable stress induced depression model rats and to explore the possible association between its antidepressant-like effect and antioxidative activity by measuring erythrocyte superoxide dismutase (SOD) activity and plasma malondialdehyde (MDA) level of the experimental animals. With the exposure to stressor once daily for consecutive 5 weeks, liquiritin and a positive control drug fluoxetine were administered via gastric intubation to rats once daily for consecutive 3 weeks from the 3rd week. The results showed that CVS reduced open-field activity and sucrose consumption significantly, but increased immobility time in forced swimming test. Treatment of liquiritin could effectively reverse alteration in immobility time and sucrose consumption but did not show significant effect on open-field activity. Moreover, liquiritin could increase SOD activity, inhibit lipid peroxidation, and lessen production of MDA, while fluoxetine did not. In conclusion, the present study demonstrated a potential antidepressant-like effect of liquiritin treatment on chronic variable stress induced depression model rats, which might be related to defense of liquiritin against oxidative stress. SN - 0166-4328 UR - https://www.unboundmedicine.com/medline/citation/18655806/Antidepressant_like_effect_of_liquiritin_from_Glycyrrhiza_uralensis_in_chronic_variable_stress_induced_depression_model_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166-4328(08)00330-6 DB - PRIME DP - Unbound Medicine ER -