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Daily ingestion of alginate reduces energy intake in free-living subjects.
Appetite. 2008 Nov; 51(3):713-9.A

Abstract

Sodium alginate is a seaweed-derived fibre that has previously been shown to moderate appetite in models of acute feeding. The mechanisms underlying this effect may include slowed gastric clearance and attenuated uptake from the small intestine. In order to assess whether alginate could be effective as a means of appetite control in free-living adults, 68 males and females (BMI range: 18.50-32.81 kg/m(2)) completed this randomised, controlled two-way crossover intervention to compare the effects of 7 day daily ingestion of a strong-gelling sodium alginate formulation against a control. A sodium alginate with a high-guluronate content was chosen because, upon ingestion, it forms a strong gel in the presence of calcium ions. Daily preprandial ingestion of the sodium alginate formulation produced a significant 134.8 kcal (7%) reduction in mean daily energy intake. This reduced energy intake was underwritten by significant reductions in mean daily carbohydrate, sugar, fat, saturated fat and protein intakes. The absence of any significant interaction effects between the main effect of preload type and those of gender, BMI classification and/or timing of preload delivery indicates the efficacy of this treatment for individuals in different settings. These findings suggest a possible role for a strong-gelling sodium alginate formulation in the future management of overweight and obesity.

Authors+Show Affiliations

Food and Nutrition Group, Faculty of Organisation and Management, Sheffield Hallam University, Arundel Gate, Sheffield, UK. j.r.paxman@shu.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18655817

Citation

Paxman, J R., et al. "Daily Ingestion of Alginate Reduces Energy Intake in Free-living Subjects." Appetite, vol. 51, no. 3, 2008, pp. 713-9.
Paxman JR, Richardson JC, Dettmar PW, et al. Daily ingestion of alginate reduces energy intake in free-living subjects. Appetite. 2008;51(3):713-9.
Paxman, J. R., Richardson, J. C., Dettmar, P. W., & Corfe, B. M. (2008). Daily ingestion of alginate reduces energy intake in free-living subjects. Appetite, 51(3), 713-9. https://doi.org/10.1016/j.appet.2008.06.013
Paxman JR, et al. Daily Ingestion of Alginate Reduces Energy Intake in Free-living Subjects. Appetite. 2008;51(3):713-9. PubMed PMID: 18655817.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Daily ingestion of alginate reduces energy intake in free-living subjects. AU - Paxman,J R, AU - Richardson,J C, AU - Dettmar,P W, AU - Corfe,B M, Y1 - 2008/07/04/ PY - 2007/10/02/received PY - 2008/06/19/revised PY - 2008/06/30/accepted PY - 2008/7/29/pubmed PY - 2009/1/24/medline PY - 2008/7/29/entrez SP - 713 EP - 9 JF - Appetite JO - Appetite VL - 51 IS - 3 N2 - Sodium alginate is a seaweed-derived fibre that has previously been shown to moderate appetite in models of acute feeding. The mechanisms underlying this effect may include slowed gastric clearance and attenuated uptake from the small intestine. In order to assess whether alginate could be effective as a means of appetite control in free-living adults, 68 males and females (BMI range: 18.50-32.81 kg/m(2)) completed this randomised, controlled two-way crossover intervention to compare the effects of 7 day daily ingestion of a strong-gelling sodium alginate formulation against a control. A sodium alginate with a high-guluronate content was chosen because, upon ingestion, it forms a strong gel in the presence of calcium ions. Daily preprandial ingestion of the sodium alginate formulation produced a significant 134.8 kcal (7%) reduction in mean daily energy intake. This reduced energy intake was underwritten by significant reductions in mean daily carbohydrate, sugar, fat, saturated fat and protein intakes. The absence of any significant interaction effects between the main effect of preload type and those of gender, BMI classification and/or timing of preload delivery indicates the efficacy of this treatment for individuals in different settings. These findings suggest a possible role for a strong-gelling sodium alginate formulation in the future management of overweight and obesity. SN - 0195-6663 UR - https://www.unboundmedicine.com/medline/citation/18655817/Daily_ingestion_of_alginate_reduces_energy_intake_in_free_living_subjects_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0195-6663(08)00520-5 DB - PRIME DP - Unbound Medicine ER -