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The effects of selenium on oxidative stress biomarkers in the freshwater characid fish matrinxã, Brycon cephalus (Günther, 1869) exposed to organophosphate insecticide Folisuper 600 BR (methyl parathion).

Abstract

Methyl parathion (MP), an organophosphate widely applied in agriculture and aquaculture, induces oxidative stress due to free radical generation and changes in the antioxidant defense system. The antioxidant roles of selenium (Se) were evaluated in Brycon cephalus exposed to 2 mg L(-1) of Folisuper 600 BR (MP commercial formulation - MPc, 600 g L(-1)) for 96 h. Catalase (CAT), glutathione peroxidase (GPx), superoxide dismutase (SOD), glutathione S-transferase (GST), reduced glutathione (GSH) and lipid peroxidation (LPO) levels in the gills, white muscle and liver were evaluated in fish fed on diets containing 0 or 1.5 mg Se kg(-1) for 8 weeks. In fish treated with a Se-free diet, the MPc exposure increased SOD and CAT activities in all tissues. However, the GPx activity decreased in white muscle and gills whereas no alterations were observed in the liver. MPc also increased GST activity in all tissues with a concurrent decrease in GSH levels. LPO values increased in white muscle and gills and did not change in liver after MPc exposure. A Se-supplemented diet reversed these findings, preventing increases in LPO levels and concurrent decreases in GPx activity in gills and white muscle. Similarly, GSH levels were maintained in all tissue after MPc exposure. These results suggest that dietary Se supplementation protects cells against MPc-induced oxidative stress.

Authors+Show Affiliations

Department of Physiological Science, Federal University of São Carlos, São Carlos, São Paulo, Brazil.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18655848

Citation

Monteiro, Diana Amaral, et al. "The Effects of Selenium On Oxidative Stress Biomarkers in the Freshwater Characid Fish Matrinxã, Brycon Cephalus (Günther, 1869) Exposed to Organophosphate Insecticide Folisuper 600 BR (methyl Parathion)." Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP, vol. 149, no. 1, 2009, pp. 40-9.
Monteiro DA, Rantin FT, Kalinin AL. The effects of selenium on oxidative stress biomarkers in the freshwater characid fish matrinxã, Brycon cephalus (Günther, 1869) exposed to organophosphate insecticide Folisuper 600 BR (methyl parathion). Comp Biochem Physiol C Toxicol Pharmacol. 2009;149(1):40-9.
Monteiro, D. A., Rantin, F. T., & Kalinin, A. L. (2009). The effects of selenium on oxidative stress biomarkers in the freshwater characid fish matrinxã, Brycon cephalus (Günther, 1869) exposed to organophosphate insecticide Folisuper 600 BR (methyl parathion). Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP, 149(1), 40-9. https://doi.org/10.1016/j.cbpc.2008.06.012
Monteiro DA, Rantin FT, Kalinin AL. The Effects of Selenium On Oxidative Stress Biomarkers in the Freshwater Characid Fish Matrinxã, Brycon Cephalus (Günther, 1869) Exposed to Organophosphate Insecticide Folisuper 600 BR (methyl Parathion). Comp Biochem Physiol C Toxicol Pharmacol. 2009;149(1):40-9. PubMed PMID: 18655848.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of selenium on oxidative stress biomarkers in the freshwater characid fish matrinxã, Brycon cephalus (Günther, 1869) exposed to organophosphate insecticide Folisuper 600 BR (methyl parathion). AU - Monteiro,Diana Amaral, AU - Rantin,Francisco Tadeu, AU - Kalinin,Ana Lúcia, Y1 - 2008/07/04/ PY - 2008/05/15/received PY - 2008/06/27/revised PY - 2008/06/28/accepted PY - 2008/7/29/pubmed PY - 2009/1/30/medline PY - 2008/7/29/entrez SP - 40 EP - 9 JF - Comparative biochemistry and physiology. Toxicology & pharmacology : CBP JO - Comp. Biochem. Physiol. C Toxicol. Pharmacol. VL - 149 IS - 1 N2 - Methyl parathion (MP), an organophosphate widely applied in agriculture and aquaculture, induces oxidative stress due to free radical generation and changes in the antioxidant defense system. The antioxidant roles of selenium (Se) were evaluated in Brycon cephalus exposed to 2 mg L(-1) of Folisuper 600 BR (MP commercial formulation - MPc, 600 g L(-1)) for 96 h. Catalase (CAT), glutathione peroxidase (GPx), superoxide dismutase (SOD), glutathione S-transferase (GST), reduced glutathione (GSH) and lipid peroxidation (LPO) levels in the gills, white muscle and liver were evaluated in fish fed on diets containing 0 or 1.5 mg Se kg(-1) for 8 weeks. In fish treated with a Se-free diet, the MPc exposure increased SOD and CAT activities in all tissues. However, the GPx activity decreased in white muscle and gills whereas no alterations were observed in the liver. MPc also increased GST activity in all tissues with a concurrent decrease in GSH levels. LPO values increased in white muscle and gills and did not change in liver after MPc exposure. A Se-supplemented diet reversed these findings, preventing increases in LPO levels and concurrent decreases in GPx activity in gills and white muscle. Similarly, GSH levels were maintained in all tissue after MPc exposure. These results suggest that dietary Se supplementation protects cells against MPc-induced oxidative stress. SN - 1532-0456 UR - https://www.unboundmedicine.com/medline/citation/18655848/The_effects_of_selenium_on_oxidative_stress_biomarkers_in_the_freshwater_characid_fish_matrinxã_Brycon_cephalus__Günther_1869__exposed_to_organophosphate_insecticide_Folisuper_600_BR__methyl_parathion__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1532-0456(08)00130-0 DB - PRIME DP - Unbound Medicine ER -