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[Clinical and physiological features of chronic pulmonary emphysema with paroxysmal dyspnea attacks masquerading as bronchial asthma--improvement of respiratory function after combination therapy of intravenous aminophylline and subcutaneous epinephrine following daily oral administration of prednisolone].
Nihon Kyobu Shikkan Gakkai Zasshi. 1991 Apr; 29(4):460-8.NK

Abstract

Cases of chronic pulmonary emphysema accompanied with paroxysmal dyspnea attacks are often misdiagnosed as bronchial asthma. These patients repeatedly fall into a state of life-threatening respiratory failure. We must make an accurate diagnosis of emphysema to provide care of them. To clarify the possibility of doing this, we investigated the clinical and physiological features (primarily respiratory function) of emphysema. We observed twenty-five patients with chronic pulmonary emphysema and with chronic bronchial asthma, previously confirmed by selective alveolo-bronchogram (SAB); this technique reliably diagnoses emphysema, but often induces dyspnea attacks due to the stimulation resulting from intratracheal and intrabronchial procedures. In eight patients, chronic pulmonary emphysema was accompanied by an attack of paroxysmal wheezing and dyspnea; chronic pulmonary emphysema with wheezing (WPE). In eight other patients, chronic pulmonary emphysema was present without such attacks; usual pulmonary emphysema (UPE). In the final nine patients, chronic bronchial asthma (CBA) was present, while emphysema was ruled out by means of SAB. In all patients, we measured respiratory function before and after the combination therapy of intravenous aminophylline and subcutaneous epinephrine, which followed daily oral administration of prednisolone (PAE-treatment). In the WPE group, significant increases in measurement of various respiratory functions, including VC, RV, RV/TLC%, FVC, FEV1.0, PFR and V75 (p less than .05 excluded in FEV1.0 and PFR were p less than .01), were found after the PAE-treatment, compared with the values revealed before the treatment. In the UPE group, there were few changes PAE-treatment, compared with the values revealed before the treatment.(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Department of Medicine and Clinical Immunology, Dokkyo University School of Medicine, Tochigi, Japan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

jpn

PubMed ID

1865598

Citation

Toda, M, et al. "[Clinical and Physiological Features of Chronic Pulmonary Emphysema With Paroxysmal Dyspnea Attacks Masquerading as Bronchial Asthma--improvement of Respiratory Function After Combination Therapy of Intravenous Aminophylline and Subcutaneous Epinephrine Following Daily Oral Administration of Prednisolone]." Nihon Kyobu Shikkan Gakkai Zasshi, vol. 29, no. 4, 1991, pp. 460-8.
Toda M, Motojima S, Fukuda T, et al. [Clinical and physiological features of chronic pulmonary emphysema with paroxysmal dyspnea attacks masquerading as bronchial asthma--improvement of respiratory function after combination therapy of intravenous aminophylline and subcutaneous epinephrine following daily oral administration of prednisolone]. Nihon Kyobu Shikkan Gakkai Zasshi. 1991;29(4):460-8.
Toda, M., Motojima, S., Fukuda, T., & Makino, S. (1991). [Clinical and physiological features of chronic pulmonary emphysema with paroxysmal dyspnea attacks masquerading as bronchial asthma--improvement of respiratory function after combination therapy of intravenous aminophylline and subcutaneous epinephrine following daily oral administration of prednisolone]. Nihon Kyobu Shikkan Gakkai Zasshi, 29(4), 460-8.
Toda M, et al. [Clinical and Physiological Features of Chronic Pulmonary Emphysema With Paroxysmal Dyspnea Attacks Masquerading as Bronchial Asthma--improvement of Respiratory Function After Combination Therapy of Intravenous Aminophylline and Subcutaneous Epinephrine Following Daily Oral Administration of Prednisolone]. Nihon Kyobu Shikkan Gakkai Zasshi. 1991;29(4):460-8. PubMed PMID: 1865598.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Clinical and physiological features of chronic pulmonary emphysema with paroxysmal dyspnea attacks masquerading as bronchial asthma--improvement of respiratory function after combination therapy of intravenous aminophylline and subcutaneous epinephrine following daily oral administration of prednisolone]. AU - Toda,M, AU - Motojima,S, AU - Fukuda,T, AU - Makino,S, PY - 1991/4/1/pubmed PY - 1991/4/1/medline PY - 1991/4/1/entrez SP - 460 EP - 8 JF - Nihon Kyobu Shikkan Gakkai zasshi JO - Nihon Kyobu Shikkan Gakkai Zasshi VL - 29 IS - 4 N2 - Cases of chronic pulmonary emphysema accompanied with paroxysmal dyspnea attacks are often misdiagnosed as bronchial asthma. These patients repeatedly fall into a state of life-threatening respiratory failure. We must make an accurate diagnosis of emphysema to provide care of them. To clarify the possibility of doing this, we investigated the clinical and physiological features (primarily respiratory function) of emphysema. We observed twenty-five patients with chronic pulmonary emphysema and with chronic bronchial asthma, previously confirmed by selective alveolo-bronchogram (SAB); this technique reliably diagnoses emphysema, but often induces dyspnea attacks due to the stimulation resulting from intratracheal and intrabronchial procedures. In eight patients, chronic pulmonary emphysema was accompanied by an attack of paroxysmal wheezing and dyspnea; chronic pulmonary emphysema with wheezing (WPE). In eight other patients, chronic pulmonary emphysema was present without such attacks; usual pulmonary emphysema (UPE). In the final nine patients, chronic bronchial asthma (CBA) was present, while emphysema was ruled out by means of SAB. In all patients, we measured respiratory function before and after the combination therapy of intravenous aminophylline and subcutaneous epinephrine, which followed daily oral administration of prednisolone (PAE-treatment). In the WPE group, significant increases in measurement of various respiratory functions, including VC, RV, RV/TLC%, FVC, FEV1.0, PFR and V75 (p less than .05 excluded in FEV1.0 and PFR were p less than .01), were found after the PAE-treatment, compared with the values revealed before the treatment. In the UPE group, there were few changes PAE-treatment, compared with the values revealed before the treatment.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0301-1542 UR - https://www.unboundmedicine.com/medline/citation/1865598/[Clinical_and_physiological_features_of_chronic_pulmonary_emphysema_with_paroxysmal_dyspnea_attacks_masquerading_as_bronchial_asthma__improvement_of_respiratory_function_after_combination_therapy_of_intravenous_aminophylline_and_subcutaneous_epinephrine_following_daily_oral_administration_of_prednisolone]_ L2 - http://www.diseaseinfosearch.org/result/633 DB - PRIME DP - Unbound Medicine ER -