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Lignans and other constituents of the fruits of Euterpe oleracea (Acai) with antioxidant and cytoprotective activities.
J Agric Food Chem. 2008 Sep 10; 56(17):7759-64.JA

Abstract

Using a hydroxyl radical scavenging assay, bioactivity-guided fractionation of a methanol-soluble extract of the fruits of Euterpe oleracea (acai) led to the isolation of 22 compounds of previously known structure. Altogether, 14 of these isolates were found to be active in an in vitro hydroxyl radical scavenging assay and seven of these isolates in a 1,1-diphenyl-2-picrylhydrazyl radical scavenging assay. Dihydroconiferyl alcohol, (+)-lariciresinol, (+)-pinoresinol, (+)-syringaresinol, and protocatechuic acid methyl ester exhibited cytoprotective activity in cultured MCF-7 cells stressed by H2O2. Lignans have not been previously reported as constituents of this species and were found to be representative of the aryltetrahydronaphthalene, dihydrobenzofuran, furofuran, 8-O-4'-neolignan, and tetrahydrofuran structural types.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Chin YW
Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, 500 West 12th Avenue, Columbus, Ohio 43210, USA.
Chai HB
No affiliation info available
Keller WJ
No affiliation info available
Kinghorn AD
No affiliation info available

MeSH

AntioxidantsArecaceaeCell LineCytoprotectionFree Radical ScavengersFruitHydroxyl RadicalLignansOxidative StressPlant Extracts

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18656934

Citation

Chin, Young-Won, et al. "Lignans and Other Constituents of the Fruits of Euterpe Oleracea (Acai) With Antioxidant and Cytoprotective Activities." Journal of Agricultural and Food Chemistry, vol. 56, no. 17, 2008, pp. 7759-64.
Chin YW, Chai HB, Keller WJ, et al. Lignans and other constituents of the fruits of Euterpe oleracea (Acai) with antioxidant and cytoprotective activities. J Agric Food Chem. 2008;56(17):7759-64.
Chin, Y. W., Chai, H. B., Keller, W. J., & Kinghorn, A. D. (2008). Lignans and other constituents of the fruits of Euterpe oleracea (Acai) with antioxidant and cytoprotective activities. Journal of Agricultural and Food Chemistry, 56(17), 7759-64. https://doi.org/10.1021/jf801792n
Chin YW, et al. Lignans and Other Constituents of the Fruits of Euterpe Oleracea (Acai) With Antioxidant and Cytoprotective Activities. J Agric Food Chem. 2008 Sep 10;56(17):7759-64. PubMed PMID: 18656934.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lignans and other constituents of the fruits of Euterpe oleracea (Acai) with antioxidant and cytoprotective activities. AU - Chin,Young-Won, AU - Chai,Hee-Byung, AU - Keller,William J, AU - Kinghorn,A Douglas, Y1 - 2008/07/26/ PY - 2008/7/29/pubmed PY - 2008/11/1/medline PY - 2008/7/29/entrez SP - 7759 EP - 64 JF - Journal of agricultural and food chemistry JO - J Agric Food Chem VL - 56 IS - 17 N2 - Using a hydroxyl radical scavenging assay, bioactivity-guided fractionation of a methanol-soluble extract of the fruits of Euterpe oleracea (acai) led to the isolation of 22 compounds of previously known structure. Altogether, 14 of these isolates were found to be active in an in vitro hydroxyl radical scavenging assay and seven of these isolates in a 1,1-diphenyl-2-picrylhydrazyl radical scavenging assay. Dihydroconiferyl alcohol, (+)-lariciresinol, (+)-pinoresinol, (+)-syringaresinol, and protocatechuic acid methyl ester exhibited cytoprotective activity in cultured MCF-7 cells stressed by H2O2. Lignans have not been previously reported as constituents of this species and were found to be representative of the aryltetrahydronaphthalene, dihydrobenzofuran, furofuran, 8-O-4'-neolignan, and tetrahydrofuran structural types. SN - 1520-5118 UR - https://www.unboundmedicine.com/medline/citation/18656934/Lignans_and_other_constituents_of_the_fruits_of_Euterpe_oleracea__Acai__with_antioxidant_and_cytoprotective_activities_ L2 - https://doi.org/10.1021/jf801792n DB - PRIME DP - Unbound Medicine ER -