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Low-dose lactose in drugs neither increases breath hydrogen excretion nor causes gastrointestinal symptoms.
Aliment Pharmacol Ther. 2008 Oct 15; 28(8):1003-12.AP

Abstract

BACKGROUND

Despite the reported tolerance to a low dose of lactose, many lactose malabsorbers follow a rigorous lactose-free diet also avoiding lactose-containing drugs. Up to now, only a few case reports have described the onset of gastrointestinal symptoms in lactose malabsorbers following the ingestion of these drugs. It has been suggested that capsules/tablets contain no more than 400 mg of lactose.

AIM

To evaluate breath H(2) excretion and intolerance symptoms after ingestion of a capsule containing 400 mg of lactose or placebo through a randomized, cross-over, double-blind, controlled study.

METHODS

Seventy-seven lactose maldigesters with intolerance underwent two H2 breath tests with both 400 mg of lactose and 400 mg of placebo. Gastrointestinal symptoms occurring in the 8 h following the ingestion of different substrates were evaluated by a visual-analogue scale.

RESULTS

Ingestion of 400 mg of lactose did not cause a significant difference in breath H2 excretion or in the severity of gastrointestinal symptoms compared to placebo.

CONCLUSION

In patients with lactase deficiency, drugs containing 400 mg of lactose or less can be used safely.

Authors+Show Affiliations

Institute of Internal Medicine, Catholic University, Rome, Italy. mmontalto@rm.unicatt.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

18657134

Citation

Montalto, M, et al. "Low-dose Lactose in Drugs Neither Increases Breath Hydrogen Excretion nor Causes Gastrointestinal Symptoms." Alimentary Pharmacology & Therapeutics, vol. 28, no. 8, 2008, pp. 1003-12.
Montalto M, Gallo A, Santoro L, et al. Low-dose lactose in drugs neither increases breath hydrogen excretion nor causes gastrointestinal symptoms. Aliment Pharmacol Ther. 2008;28(8):1003-12.
Montalto, M., Gallo, A., Santoro, L., D'Onofrio, F., Curigliano, V., Covino, M., Cammarota, G., Grieco, A., Gasbarrini, A., & Gasbarrini, G. (2008). Low-dose lactose in drugs neither increases breath hydrogen excretion nor causes gastrointestinal symptoms. Alimentary Pharmacology & Therapeutics, 28(8), 1003-12. https://doi.org/10.1111/j.1365-2036.2008.03815.x
Montalto M, et al. Low-dose Lactose in Drugs Neither Increases Breath Hydrogen Excretion nor Causes Gastrointestinal Symptoms. Aliment Pharmacol Ther. 2008 Oct 15;28(8):1003-12. PubMed PMID: 18657134.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Low-dose lactose in drugs neither increases breath hydrogen excretion nor causes gastrointestinal symptoms. AU - Montalto,M, AU - Gallo,A, AU - Santoro,L, AU - D'Onofrio,F, AU - Curigliano,V, AU - Covino,M, AU - Cammarota,G, AU - Grieco,A, AU - Gasbarrini,A, AU - Gasbarrini,G, Y1 - 2008/07/24/ PY - 2008/7/29/pubmed PY - 2009/2/21/medline PY - 2008/7/29/entrez SP - 1003 EP - 12 JF - Alimentary pharmacology & therapeutics JO - Aliment Pharmacol Ther VL - 28 IS - 8 N2 - BACKGROUND: Despite the reported tolerance to a low dose of lactose, many lactose malabsorbers follow a rigorous lactose-free diet also avoiding lactose-containing drugs. Up to now, only a few case reports have described the onset of gastrointestinal symptoms in lactose malabsorbers following the ingestion of these drugs. It has been suggested that capsules/tablets contain no more than 400 mg of lactose. AIM: To evaluate breath H(2) excretion and intolerance symptoms after ingestion of a capsule containing 400 mg of lactose or placebo through a randomized, cross-over, double-blind, controlled study. METHODS: Seventy-seven lactose maldigesters with intolerance underwent two H2 breath tests with both 400 mg of lactose and 400 mg of placebo. Gastrointestinal symptoms occurring in the 8 h following the ingestion of different substrates were evaluated by a visual-analogue scale. RESULTS: Ingestion of 400 mg of lactose did not cause a significant difference in breath H2 excretion or in the severity of gastrointestinal symptoms compared to placebo. CONCLUSION: In patients with lactase deficiency, drugs containing 400 mg of lactose or less can be used safely. SN - 1365-2036 UR - https://www.unboundmedicine.com/medline/citation/18657134/Low_dose_lactose_in_drugs_neither_increases_breath_hydrogen_excretion_nor_causes_gastrointestinal_symptoms_ L2 - https://doi.org/10.1111/j.1365-2036.2008.03815.x DB - PRIME DP - Unbound Medicine ER -