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Thalidomide inhibits epidermal growth factor-induced cell growth in mouse and human monocytic leukemia cells via Ras inactivation.
Biochem Biophys Res Commun. 2008 Oct 03; 374(4):683-7.BB

Abstract

The effect of thalidomide on epidermal growth factor (EGF)-induced cell growth was examined. Thalidomide inhibited EGF-induced cell growth in mouse and human monocytic leukemia cells, RAW 264.7, U937 and THP-1. Thalidomide inhibited EGF-induced phosphorylation of extracellular signal regulated kinase (ERK) 1/2, but not p38 and stress-activated protein kinase (SAPK)/JNK. The phosphorylation of MEK1/2 and Raf at Ser 338 as the upstream molecules of ERK 1/2 was also prevented by thalidomide. Further, it inhibited EGF-induced Ras activation through preventing the transition to GTP-bound active Ras. Thalidomide inhibited the Ras activation induced by lipopolysaccharide (LPS) and vascular endothelial growth factor (VEGF) as well as EGF. There was no significant difference in the expression and function of EGF receptor between thalidomide-treated and non-treated cells. Therefore, thalidomide was suggested to inhibit EGF-induced cell growth via inactivation of Ras.

Authors+Show Affiliations

Department of Microbiology and Immunology, Aichi Medical University School of Medicine, Nagakute, Aichi 480-1195, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18662673

Citation

Noman, Abu Shadat M., et al. "Thalidomide Inhibits Epidermal Growth Factor-induced Cell Growth in Mouse and Human Monocytic Leukemia Cells Via Ras Inactivation." Biochemical and Biophysical Research Communications, vol. 374, no. 4, 2008, pp. 683-7.
Noman AS, Koide N, Khuda II, et al. Thalidomide inhibits epidermal growth factor-induced cell growth in mouse and human monocytic leukemia cells via Ras inactivation. Biochem Biophys Res Commun. 2008;374(4):683-7.
Noman, A. S., Koide, N., Khuda, I. I., Dagvadorj, J., Tumurkhuu, G., Naiki, Y., Komatsu, T., Yoshida, T., & Yokochi, T. (2008). Thalidomide inhibits epidermal growth factor-induced cell growth in mouse and human monocytic leukemia cells via Ras inactivation. Biochemical and Biophysical Research Communications, 374(4), 683-7. https://doi.org/10.1016/j.bbrc.2008.07.090
Noman AS, et al. Thalidomide Inhibits Epidermal Growth Factor-induced Cell Growth in Mouse and Human Monocytic Leukemia Cells Via Ras Inactivation. Biochem Biophys Res Commun. 2008 Oct 3;374(4):683-7. PubMed PMID: 18662673.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Thalidomide inhibits epidermal growth factor-induced cell growth in mouse and human monocytic leukemia cells via Ras inactivation. AU - Noman,Abu Shadat M, AU - Koide,Naoki, AU - Khuda,Imtiaz I-E, AU - Dagvadorj,Jargalsaikhan, AU - Tumurkhuu,Gantsetseg, AU - Naiki,Yoshikazu, AU - Komatsu,Takayuki, AU - Yoshida,Tomoaki, AU - Yokochi,Takashi, Y1 - 2008/07/26/ PY - 2008/07/17/received PY - 2008/07/18/accepted PY - 2008/7/30/pubmed PY - 2008/9/11/medline PY - 2008/7/30/entrez SP - 683 EP - 7 JF - Biochemical and biophysical research communications JO - Biochem Biophys Res Commun VL - 374 IS - 4 N2 - The effect of thalidomide on epidermal growth factor (EGF)-induced cell growth was examined. Thalidomide inhibited EGF-induced cell growth in mouse and human monocytic leukemia cells, RAW 264.7, U937 and THP-1. Thalidomide inhibited EGF-induced phosphorylation of extracellular signal regulated kinase (ERK) 1/2, but not p38 and stress-activated protein kinase (SAPK)/JNK. The phosphorylation of MEK1/2 and Raf at Ser 338 as the upstream molecules of ERK 1/2 was also prevented by thalidomide. Further, it inhibited EGF-induced Ras activation through preventing the transition to GTP-bound active Ras. Thalidomide inhibited the Ras activation induced by lipopolysaccharide (LPS) and vascular endothelial growth factor (VEGF) as well as EGF. There was no significant difference in the expression and function of EGF receptor between thalidomide-treated and non-treated cells. Therefore, thalidomide was suggested to inhibit EGF-induced cell growth via inactivation of Ras. SN - 1090-2104 UR - https://www.unboundmedicine.com/medline/citation/18662673/Thalidomide_inhibits_epidermal_growth_factor_induced_cell_growth_in_mouse_and_human_monocytic_leukemia_cells_via_Ras_inactivation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-291X(08)01432-0 DB - PRIME DP - Unbound Medicine ER -