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Intra-amygdala anxiogenic drug infusion prior to retrieval biases rats towards the use of habit memory.
Neurobiol Learn Mem. 2008 Nov; 90(4):616-23.NL

Abstract

In a dual-solution plus-maze task that can be acquired using either hippocampus-dependent "cognitive/place" learning or dorsal striatal-dependent "habit/response" learning, pre-acquisition peripheral or intra-basolateral amygdala (BLA) injections of anxiogenic drugs result in the predominant use of response learning. The present experiments examined the effect of anxiogenic drug treatment on the relative use of multiple memory systems when administered prior to memory retrieval. Adult male Long-Evans rats were trained for two days (6 trials/day, 30s ITI) in a dual-solution plus-maze task to swim from the same start point (south) to an escape platform that was located in a consistent goal arm (west). On day three, prior to a memory retrieval probe trial from a novel start point (north), rats received a peripheral (0.03, 0.1 or 0.3 mg/kg), or intra-BLA (0.1 microg/0.5 microl) injection of the anxiogenic alpha(2)-adrenoreceptor antagonist RS 79948-197, or saline. Relative to saline controls, rats receiving either peripheral or intra-BLA infusions of RS 79948-197 predominantly displayed response learning on the probe trial. In an additional experiment peripheral (0.1 mg/kg) or intra-BLA (0.1 microg) drug injections administered prior to both acquisition and retrieval also resulted in the predominant use of response learning. The findings indicate that (1) similar to acquisition, peripheral injection of an anxiogenic drug prior to memory retrieval biases rats towards the use of habit/response memory, (2) intra-BLA infusions of an anxiogenic drug is sufficient to produce this modulatory effect of emotional state on memory retrieval, and (3) state-dependency does not appear to play a role in the effects of anxiogenic drug treatment on multiple memory system use. The findings may have implications for understanding the interaction between brain function, emotion, and the relative use of multiple memory systems in human psychopathology.

Authors+Show Affiliations

Department of Psychology, Texas A&M University, College Station, TX 77843, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

18662795

Citation

Elliott, Audrea E., and Mark G. Packard. "Intra-amygdala Anxiogenic Drug Infusion Prior to Retrieval Biases Rats Towards the Use of Habit Memory." Neurobiology of Learning and Memory, vol. 90, no. 4, 2008, pp. 616-23.
Elliott AE, Packard MG. Intra-amygdala anxiogenic drug infusion prior to retrieval biases rats towards the use of habit memory. Neurobiol Learn Mem. 2008;90(4):616-23.
Elliott, A. E., & Packard, M. G. (2008). Intra-amygdala anxiogenic drug infusion prior to retrieval biases rats towards the use of habit memory. Neurobiology of Learning and Memory, 90(4), 616-23. https://doi.org/10.1016/j.nlm.2008.06.012
Elliott AE, Packard MG. Intra-amygdala Anxiogenic Drug Infusion Prior to Retrieval Biases Rats Towards the Use of Habit Memory. Neurobiol Learn Mem. 2008;90(4):616-23. PubMed PMID: 18662795.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intra-amygdala anxiogenic drug infusion prior to retrieval biases rats towards the use of habit memory. AU - Elliott,Audrea E, AU - Packard,Mark G, Y1 - 2008/09/02/ PY - 2008/05/14/received PY - 2008/06/24/revised PY - 2008/06/25/accepted PY - 2008/7/30/pubmed PY - 2009/2/14/medline PY - 2008/7/30/entrez SP - 616 EP - 23 JF - Neurobiology of learning and memory JO - Neurobiol Learn Mem VL - 90 IS - 4 N2 - In a dual-solution plus-maze task that can be acquired using either hippocampus-dependent "cognitive/place" learning or dorsal striatal-dependent "habit/response" learning, pre-acquisition peripheral or intra-basolateral amygdala (BLA) injections of anxiogenic drugs result in the predominant use of response learning. The present experiments examined the effect of anxiogenic drug treatment on the relative use of multiple memory systems when administered prior to memory retrieval. Adult male Long-Evans rats were trained for two days (6 trials/day, 30s ITI) in a dual-solution plus-maze task to swim from the same start point (south) to an escape platform that was located in a consistent goal arm (west). On day three, prior to a memory retrieval probe trial from a novel start point (north), rats received a peripheral (0.03, 0.1 or 0.3 mg/kg), or intra-BLA (0.1 microg/0.5 microl) injection of the anxiogenic alpha(2)-adrenoreceptor antagonist RS 79948-197, or saline. Relative to saline controls, rats receiving either peripheral or intra-BLA infusions of RS 79948-197 predominantly displayed response learning on the probe trial. In an additional experiment peripheral (0.1 mg/kg) or intra-BLA (0.1 microg) drug injections administered prior to both acquisition and retrieval also resulted in the predominant use of response learning. The findings indicate that (1) similar to acquisition, peripheral injection of an anxiogenic drug prior to memory retrieval biases rats towards the use of habit/response memory, (2) intra-BLA infusions of an anxiogenic drug is sufficient to produce this modulatory effect of emotional state on memory retrieval, and (3) state-dependency does not appear to play a role in the effects of anxiogenic drug treatment on multiple memory system use. The findings may have implications for understanding the interaction between brain function, emotion, and the relative use of multiple memory systems in human psychopathology. SN - 1095-9564 UR - https://www.unboundmedicine.com/medline/citation/18662795/Intra_amygdala_anxiogenic_drug_infusion_prior_to_retrieval_biases_rats_towards_the_use_of_habit_memory_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1074-7427(08)00114-7 DB - PRIME DP - Unbound Medicine ER -