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Projection OCT fundus imaging for visualising outer retinal pathology in non-exudative age-related macular degeneration.
Br J Ophthalmol 2009; 93(5):603-9BJ

Abstract

AIMS

To demonstrate ultrahigh-resolution, three-dimensional optical coherence tomography (3D-OCT) and projection OCT fundus imaging for enhanced visualisation of outer retinal pathology in non-exudative age-related macular degeneration (AMD).

METHODS

A high-speed, 3.5 mum resolution OCT prototype instrument was developed for the ophthalmic clinic. Eighty-three patients with non-exudative AMD were imaged. Projection OCT fundus images were generated from 3D-OCT data by selectively summing different retinal depth levels. Results were compared with standard ophthalmic examination, including fundus photography and fluorescein angiography, when indicated.

RESULTS

Projection OCT fundus imaging enhanced the visualisation of outer retinal pathology in non-exudative AMD. Different types of drusen exhibited distinct features in projection OCT images. Photoreceptor disruption was indicated by loss of the photoreceptor inner/outer segment (IS/OS) boundary and external limiting membrane (ELM). RPE atrophy can be assessed using choroid-level projection OCT images.

CONCLUSIONS

Projection OCT fundus imaging facilities rapid interpretation of large 3D-OCT data sets. Projection OCT enhances contrast and visualises outer retinal pathology not visible with standard fundus imaging or OCT fundus imaging. Projection OCT fundus images enable registration with standard ophthalmic diagnostics and cross-sectional OCT images. Outer retinal alterations can be assessed and drusen morphology, photoreceptor impairment and pigmentary abnormalities identified.

Authors+Show Affiliations

Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

18662918

Citation

Gorczynska, I, et al. "Projection OCT Fundus Imaging for Visualising Outer Retinal Pathology in Non-exudative Age-related Macular Degeneration." The British Journal of Ophthalmology, vol. 93, no. 5, 2009, pp. 603-9.
Gorczynska I, Srinivasan VJ, Vuong LN, et al. Projection OCT fundus imaging for visualising outer retinal pathology in non-exudative age-related macular degeneration. Br J Ophthalmol. 2009;93(5):603-9.
Gorczynska, I., Srinivasan, V. J., Vuong, L. N., Chen, R. W., Liu, J. J., Reichel, E., ... Fujimoto, J. G. (2009). Projection OCT fundus imaging for visualising outer retinal pathology in non-exudative age-related macular degeneration. The British Journal of Ophthalmology, 93(5), pp. 603-9. doi:10.1136/bjo.2007.136101.
Gorczynska I, et al. Projection OCT Fundus Imaging for Visualising Outer Retinal Pathology in Non-exudative Age-related Macular Degeneration. Br J Ophthalmol. 2009;93(5):603-9. PubMed PMID: 18662918.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Projection OCT fundus imaging for visualising outer retinal pathology in non-exudative age-related macular degeneration. AU - Gorczynska,I, AU - Srinivasan,V J, AU - Vuong,L N, AU - Chen,R W S, AU - Liu,J J, AU - Reichel,E, AU - Wojtkowski,M, AU - Schuman,J S, AU - Duker,J S, AU - Fujimoto,J G, Y1 - 2008/07/28/ PY - 2008/7/30/pubmed PY - 2009/5/28/medline PY - 2008/7/30/entrez SP - 603 EP - 9 JF - The British journal of ophthalmology JO - Br J Ophthalmol VL - 93 IS - 5 N2 - AIMS: To demonstrate ultrahigh-resolution, three-dimensional optical coherence tomography (3D-OCT) and projection OCT fundus imaging for enhanced visualisation of outer retinal pathology in non-exudative age-related macular degeneration (AMD). METHODS: A high-speed, 3.5 mum resolution OCT prototype instrument was developed for the ophthalmic clinic. Eighty-three patients with non-exudative AMD were imaged. Projection OCT fundus images were generated from 3D-OCT data by selectively summing different retinal depth levels. Results were compared with standard ophthalmic examination, including fundus photography and fluorescein angiography, when indicated. RESULTS: Projection OCT fundus imaging enhanced the visualisation of outer retinal pathology in non-exudative AMD. Different types of drusen exhibited distinct features in projection OCT images. Photoreceptor disruption was indicated by loss of the photoreceptor inner/outer segment (IS/OS) boundary and external limiting membrane (ELM). RPE atrophy can be assessed using choroid-level projection OCT images. CONCLUSIONS: Projection OCT fundus imaging facilities rapid interpretation of large 3D-OCT data sets. Projection OCT enhances contrast and visualises outer retinal pathology not visible with standard fundus imaging or OCT fundus imaging. Projection OCT fundus images enable registration with standard ophthalmic diagnostics and cross-sectional OCT images. Outer retinal alterations can be assessed and drusen morphology, photoreceptor impairment and pigmentary abnormalities identified. SN - 1468-2079 UR - https://www.unboundmedicine.com/medline/citation/18662918/Projection_OCT_fundus_imaging_for_visualising_outer_retinal_pathology_in_non_exudative_age_related_macular_degeneration_ L2 - http://bjo.bmj.com/cgi/pmidlookup?view=long&pmid=18662918 DB - PRIME DP - Unbound Medicine ER -