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Outcomes of stage 3-5 chronic kidney disease before end-stage renal disease at a single center in Taiwan.
Nephron Clin Pract. 2008; 109(3):c109-18.NC

Abstract

BACKGROUND

Taiwan has the highest incidence of end-stage renal disease (ESRD) in the world, but little is known about the outcomes of patients with chronic kidney disease (CKD) before ESRD in Taiwan. This study investigated the rate of renal progression and predictors for ESRD and death in a prospective cohort of patients under usual nephrologic care at a single center.

METHODS

A total of 433 patients at CKD stage 3-5 short of dialysis were recruited from nephrology clinics. Patients were monitored for up to 36 months or until ESRD, death or loss to follow-up. Glomerular filtration rates (GFR) were calculated by the Modification of Diet in Renal Disease abbreviated formula.

RESULTS

At baseline, mean age was 65.6 years, 61.7% were male, 33.3% were diabetic and 29.1% had cardiovascular diseases (CVD). At the end of follow-up, 123 patients (28.4%) had advanced to ESRD and 41 (9.5%) had died. Mean annual declines in GFR were 2.24, 4.22, and 3.23 ml/min/1.73 m(2) for stages 3, 4, and 5, respectively. By Cox regression model, patients with CVD, lower BMI and higher systolic BP were more likely to develop ESRD. Older patients with CVD and lower systolic BP were more likely to die.

CONCLUSION

In this CKD cohort, patients were more likely to develop ESRD than cardiovascular death. The rate of GFR decline and predictors of ESRD were comparable to those reported in Western countries. Thus, the high incidence of ESRD in Taiwan may be attributed, at least in part, to lower cardiovascular mortality.

Authors+Show Affiliations

Department of Internal Medicine, Far-Eastern Memorial Hospital, Taipei, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18663322

Citation

Chiu, Yen-Ling, et al. "Outcomes of Stage 3-5 Chronic Kidney Disease Before End-stage Renal Disease at a Single Center in Taiwan." Nephron. Clinical Practice, vol. 109, no. 3, 2008, pp. c109-18.
Chiu YL, Chien KL, Lin SL, et al. Outcomes of stage 3-5 chronic kidney disease before end-stage renal disease at a single center in Taiwan. Nephron Clin Pract. 2008;109(3):c109-18.
Chiu, Y. L., Chien, K. L., Lin, S. L., Chen, Y. M., Tsai, T. J., & Wu, K. D. (2008). Outcomes of stage 3-5 chronic kidney disease before end-stage renal disease at a single center in Taiwan. Nephron. Clinical Practice, 109(3), c109-18. https://doi.org/10.1159/000145453
Chiu YL, et al. Outcomes of Stage 3-5 Chronic Kidney Disease Before End-stage Renal Disease at a Single Center in Taiwan. Nephron Clin Pract. 2008;109(3):c109-18. PubMed PMID: 18663322.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Outcomes of stage 3-5 chronic kidney disease before end-stage renal disease at a single center in Taiwan. AU - Chiu,Yen-Ling, AU - Chien,Kuo-Liong, AU - Lin,Shuei-Liong, AU - Chen,Yung-Ming, AU - Tsai,Tun-Jun, AU - Wu,Kwan-Dun, Y1 - 2008/07/25/ PY - 2007/10/25/received PY - 2008/04/01/accepted PY - 2008/7/30/pubmed PY - 2009/3/17/medline PY - 2008/7/30/entrez SP - c109 EP - 18 JF - Nephron. Clinical practice JO - Nephron Clin Pract VL - 109 IS - 3 N2 - BACKGROUND: Taiwan has the highest incidence of end-stage renal disease (ESRD) in the world, but little is known about the outcomes of patients with chronic kidney disease (CKD) before ESRD in Taiwan. This study investigated the rate of renal progression and predictors for ESRD and death in a prospective cohort of patients under usual nephrologic care at a single center. METHODS: A total of 433 patients at CKD stage 3-5 short of dialysis were recruited from nephrology clinics. Patients were monitored for up to 36 months or until ESRD, death or loss to follow-up. Glomerular filtration rates (GFR) were calculated by the Modification of Diet in Renal Disease abbreviated formula. RESULTS: At baseline, mean age was 65.6 years, 61.7% were male, 33.3% were diabetic and 29.1% had cardiovascular diseases (CVD). At the end of follow-up, 123 patients (28.4%) had advanced to ESRD and 41 (9.5%) had died. Mean annual declines in GFR were 2.24, 4.22, and 3.23 ml/min/1.73 m(2) for stages 3, 4, and 5, respectively. By Cox regression model, patients with CVD, lower BMI and higher systolic BP were more likely to develop ESRD. Older patients with CVD and lower systolic BP were more likely to die. CONCLUSION: In this CKD cohort, patients were more likely to develop ESRD than cardiovascular death. The rate of GFR decline and predictors of ESRD were comparable to those reported in Western countries. Thus, the high incidence of ESRD in Taiwan may be attributed, at least in part, to lower cardiovascular mortality. SN - 1660-2110 UR - https://www.unboundmedicine.com/medline/citation/18663322/Outcomes_of_stage_3_5_chronic_kidney_disease_before_end_stage_renal_disease_at_a_single_center_in_Taiwan_ L2 - https://www.karger.com?DOI=10.1159/000145453 DB - PRIME DP - Unbound Medicine ER -