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Reference limits and behaviour of serum transferrin receptor in children 6-10 years of age.
Int J Lab Hematol. 2008 Aug; 30(4):306-11.IJ

Abstract

Serum transferrin receptor (sTfR) originates mostly from erythroblasts and lesser from reticulocytes. The usefulness of sTfR has been implicated in several clinical situations, mainly as a marker of accelerated erythropoiesis or iron deficiency. The assessment of sTfR may be useful in the period of rapid growth during infancy, childhood and adolescence. We evaluated sTfR and the other quantitative and qualitative parameters of the erythropoiesis (Hb, MCV, CHr, Ret-He) and of the iron storage (serum ferritin, sTfR/ferritin index) in a total of 916 children aged 6-10 years. Children were divided into three groups: (A) healthy children, (B) with storage iron deficiency (serum ferritin < 12 microg/l) and (C) Beta trait carriers (HbA2 > 3.3). We determined reference intervals by sex and by age in healthy children. sTfR showed a slight but statistically significant age related increase but did not show significant sex differences. We compared sTfR and the other parameters investigated in the three groups of children. sTfR is not a decisive parameter that can be utilized alone in discriminating the border-line situations between normal and pathologic ones but can help in completing the panel of tests in iron deficiency and in thalassaemia Beta trait carriers.

Authors+Show Affiliations

Laboratory of Hematology, Umberto I Hospital, Nocera Inferiore (Sa), Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18665828

Citation

Danise, P, et al. "Reference Limits and Behaviour of Serum Transferrin Receptor in Children 6-10 Years of Age." International Journal of Laboratory Hematology, vol. 30, no. 4, 2008, pp. 306-11.
Danise P, Maconi M, Morelli G, et al. Reference limits and behaviour of serum transferrin receptor in children 6-10 years of age. Int J Lab Hematol. 2008;30(4):306-11.
Danise, P., Maconi, M., Morelli, G., Di Palma, A., Rescigno, G., Esposito, C., Avino, D., & Talento, B. (2008). Reference limits and behaviour of serum transferrin receptor in children 6-10 years of age. International Journal of Laboratory Hematology, 30(4), 306-11. https://doi.org/10.1111/j.1751-553X.2007.00960.x
Danise P, et al. Reference Limits and Behaviour of Serum Transferrin Receptor in Children 6-10 Years of Age. Int J Lab Hematol. 2008;30(4):306-11. PubMed PMID: 18665828.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reference limits and behaviour of serum transferrin receptor in children 6-10 years of age. AU - Danise,P, AU - Maconi,M, AU - Morelli,G, AU - Di Palma,A, AU - Rescigno,G, AU - Esposito,C, AU - Avino,D, AU - Talento,B, PY - 2008/7/31/pubmed PY - 2008/10/10/medline PY - 2008/7/31/entrez SP - 306 EP - 11 JF - International journal of laboratory hematology JO - Int J Lab Hematol VL - 30 IS - 4 N2 - Serum transferrin receptor (sTfR) originates mostly from erythroblasts and lesser from reticulocytes. The usefulness of sTfR has been implicated in several clinical situations, mainly as a marker of accelerated erythropoiesis or iron deficiency. The assessment of sTfR may be useful in the period of rapid growth during infancy, childhood and adolescence. We evaluated sTfR and the other quantitative and qualitative parameters of the erythropoiesis (Hb, MCV, CHr, Ret-He) and of the iron storage (serum ferritin, sTfR/ferritin index) in a total of 916 children aged 6-10 years. Children were divided into three groups: (A) healthy children, (B) with storage iron deficiency (serum ferritin < 12 microg/l) and (C) Beta trait carriers (HbA2 > 3.3). We determined reference intervals by sex and by age in healthy children. sTfR showed a slight but statistically significant age related increase but did not show significant sex differences. We compared sTfR and the other parameters investigated in the three groups of children. sTfR is not a decisive parameter that can be utilized alone in discriminating the border-line situations between normal and pathologic ones but can help in completing the panel of tests in iron deficiency and in thalassaemia Beta trait carriers. SN - 1751-5521 UR - https://www.unboundmedicine.com/medline/citation/18665828/Reference_limits_and_behaviour_of_serum_transferrin_receptor_in_children_6_10_years_of_age_ L2 - https://doi.org/10.1111/j.1751-553X.2007.00960.x DB - PRIME DP - Unbound Medicine ER -