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Ethical problems in conducting research in acute epidemics: the Pfizer meningitis study in Nigeria as an illustration.
Dev World Bioeth 2010; 10(1):1-10DW

Abstract

The ethics of conducting research in epidemic situations have yet to account fully for differences in the proportion and acuteness of epidemics, among other factors. While epidemics most often arise from infectious diseases, not all infectious diseases are of epidemic proportions, and not all epidemics occur acutely. These and other variations constrain the generalization of ethical decision-making and impose ethical demands on the individual researcher in a way not previously highlighted. This paper discusses a number of such constraints and impositions. It applies the ethical principles enunciated by Emmanuel et al.(1) to the controversial Pfizer study in Nigeria in order to highlight the particular ethical concerns of acute epidemic research, and suggest ways of meeting such challenges. The paper recommends that research during epidemics should be partly evaluated on its own merits in order to determine its ethical appropriateness to the specific situation. Snap decisions to conduct research during acute epidemics should be resisted. Community engagement, public notification and good information management are needed to promote the ethics of conducting research during acute epidemics. Individual consent is most at risk of being compromised, and every effort should be made to ensure that it is maintained and valid. Use of data safety management boards should be routine. Acute epidemics also present opportunities to enhance the social value of research and maximize its benefits to communities. Ethical research is possible in acute epidemics, if the potential challenges are thought of ahead of time and appropriate precautions taken.

Authors+Show Affiliations

Department of Surgery, University of Nigeria Teaching Hospital, Enugu, Nigeria. ezeome95@gmail.comNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18665846

Citation

Ezeome, Emmanuel R., and Christian Simon. "Ethical Problems in Conducting Research in Acute Epidemics: the Pfizer Meningitis Study in Nigeria as an Illustration." Developing World Bioethics, vol. 10, no. 1, 2010, pp. 1-10.
Ezeome ER, Simon C. Ethical problems in conducting research in acute epidemics: the Pfizer meningitis study in Nigeria as an illustration. Dev World Bioeth. 2010;10(1):1-10.
Ezeome, E. R., & Simon, C. (2010). Ethical problems in conducting research in acute epidemics: the Pfizer meningitis study in Nigeria as an illustration. Developing World Bioethics, 10(1), pp. 1-10. doi:10.1111/j.1471-8847.2008.00239.x.
Ezeome ER, Simon C. Ethical Problems in Conducting Research in Acute Epidemics: the Pfizer Meningitis Study in Nigeria as an Illustration. Dev World Bioeth. 2010;10(1):1-10. PubMed PMID: 18665846.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ethical problems in conducting research in acute epidemics: the Pfizer meningitis study in Nigeria as an illustration. AU - Ezeome,Emmanuel R, AU - Simon,Christian, Y1 - 2008/07/28/ PY - 2008/7/31/pubmed PY - 2010/6/15/medline PY - 2008/7/31/entrez SP - 1 EP - 10 JF - Developing world bioethics JO - Dev World Bioeth VL - 10 IS - 1 N2 - The ethics of conducting research in epidemic situations have yet to account fully for differences in the proportion and acuteness of epidemics, among other factors. While epidemics most often arise from infectious diseases, not all infectious diseases are of epidemic proportions, and not all epidemics occur acutely. These and other variations constrain the generalization of ethical decision-making and impose ethical demands on the individual researcher in a way not previously highlighted. This paper discusses a number of such constraints and impositions. It applies the ethical principles enunciated by Emmanuel et al.(1) to the controversial Pfizer study in Nigeria in order to highlight the particular ethical concerns of acute epidemic research, and suggest ways of meeting such challenges. The paper recommends that research during epidemics should be partly evaluated on its own merits in order to determine its ethical appropriateness to the specific situation. Snap decisions to conduct research during acute epidemics should be resisted. Community engagement, public notification and good information management are needed to promote the ethics of conducting research during acute epidemics. Individual consent is most at risk of being compromised, and every effort should be made to ensure that it is maintained and valid. Use of data safety management boards should be routine. Acute epidemics also present opportunities to enhance the social value of research and maximize its benefits to communities. Ethical research is possible in acute epidemics, if the potential challenges are thought of ahead of time and appropriate precautions taken. SN - 1471-8847 UR - https://www.unboundmedicine.com/medline/citation/18665846/Ethical_problems_in_conducting_research_in_acute_epidemics:_the_Pfizer_meningitis_study_in_Nigeria_as_an_illustration L2 - https://doi.org/10.1111/j.1471-8847.2008.00239.x DB - PRIME DP - Unbound Medicine ER -